Journal article
Protracted rosiglitazone treatment exacerbates inflammation in white adipose tissues of adipocyte-specific Nfe2l1 knockout mice
Food and chemical toxicology, Vol.146, pp.111836-111836
12/01/2020
DOI: 10.1016/j.fct.2020.111836
PMID: 33137425
Abstract
Nuclear factor-erythroid 2-related factor 1 (NFE2L1, also known as NRF1) belongs to the CNC-bZIP family and is a master regulator of cellular adaptive responses to various stresses in many cells and tissues. Rosiglitazone (RGZ), a thiazolidinedione agonist of PPAR gamma, is widely used in the treatment of type 2 diabetes mellitus by stimulating genes which favor storage of triglycerides. Our previous studies demonstrated that loss of Nfe2l1 in adipocytes [Nfe2l1(f)-KO] resulted in diminished subcutaneous white adipose tissue (WAT) mass with adipocyte hypertrophy and severe adipose inflammation, which might be attributed, at least in part, to impaired lipolysis. However, the exact mechanism underlying this phenotype remains unclear. To further clarify the regulatory role of NFE2L1 in adipocyte lipid metabolism, we used protracted RGZ treatment to facilitate lipid accumulation in mice. In Nfe2l1(flox/flox) control mice, three weeks of RGZ treatment significantly downregulated mRNA levels of a group of inflammation-related genes in WAT. In contrast, the phenotype of Nfe2l1(f)-KO mice was aggravated showing increased transcript expression related to inflammation and pymptosis in their shrunk WAT. These findings provide deeper insight into the mechanisms by which NFE2L1 regulates the expression of a set of lipolysis-related genes and controls WAT plasticity and global energy homeostasis.
Details
- Title: Subtitle
- Protracted rosiglitazone treatment exacerbates inflammation in white adipose tissues of adipocyte-specific Nfe2l1 knockout mice
- Creators
- Suping Ren - Program of Environmental Toxicology, China.Yongyong Hou - Program of Environmental Toxicology, China.Zhuo Zuo - Program of Environmental Toxicology, China.Zhiyuan Liu - Program of Environmental Toxicology, China.Huihui Wang - China Medical UniversityYuanyuan Xu - China Medical UniversityMasayuki Yamamoto - Tohoku UniversityQiang Zhang - Emory UniversityJingqi Fu - Program of Environmental Toxicology, China.Jingbo Pi - Program of Environmental Toxicology, China.
- Resource Type
- Journal article
- Publication Details
- Food and chemical toxicology, Vol.146, pp.111836-111836
- Publisher
- Elsevier
- DOI
- 10.1016/j.fct.2020.111836
- PMID
- 33137425
- ISSN
- 0278-6915
- eISSN
- 1873-6351
- Number of pages
- 8
- Grant note
- Liaoning Pandeng Scholar 81830099; 81402661; 81502841; 81402635; 81572221 / National Natural Science Foundation of China; National Natural Science Foundation of China (NSFC) 2019JH8/10300012 / Liaoning Key Research and Development Guidance Plan
- Language
- English
- Date published
- 12/01/2020
- Academic Unit
- Neurology
- Record Identifier
- 9984303019502771
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