Journal article
Protriptyline kinetics
Clinical pharmacology and therapeutics, Vol.23(5), pp.580-584
05/1978
DOI: 10.1002/cpt1978235580
PMID: 639433
Abstract
The kinetics of protriptyline were examined in 8 subjects after a single oral dose of 30 mg protriptyline hydrochloride. Peak protriptyline levels ranged from 10.4 to 22.3 ng/ml and were reached 6 to 12 hr after the oral dose. The mean protriptyline half‐life (t½) was 74.3 hr and ranged from 53.6 to 91.7 hr in individual subjects, confirming the long t½ of protriptyline reported by Moody and associates. The estimated first‐pass metabolism of protriptyline was relatively small, ranging from 10% to 25% of the oral dose, assuming complete absorption. The mean volume of distribution was 22.5 L/kg and ranged from 15.0 to 31.2 L/kg. No relationship was found between the kinetics of protriptyline and those of doxepin studied previously in 7 of the 8 subjects.
Details
- Title: Subtitle
- Protriptyline kinetics
- Creators
- Vincent E ZieglerJohn T BiggsLaurence T WylieWilliam H CoryellKathleen M HaniflDonald J HawfSamuel H Rosen
- Resource Type
- Journal article
- Publication Details
- Clinical pharmacology and therapeutics, Vol.23(5), pp.580-584
- DOI
- 10.1002/cpt1978235580
- PMID
- 639433
- ISSN
- 0009-9236
- eISSN
- 1532-6535
- Number of pages
- 5
- Language
- English
- Date published
- 05/1978
- Academic Unit
- Psychiatry
- Record Identifier
- 9984003446902771
Metrics
24 Record Views