Journal article
Proviral role of caspase-6 in coronavirus infections
Cell research, Vol.33, pp.7-8
01/2023
DOI: 10.1038/s41422-022-00728-5
PMCID: PMC9490723
PMID: 36131099
Abstract
Pathogenic human coronaviruses induce apoptosis in infected cells. Caspase-6 activated under apoptotic conditions proteolytically cleaves the nucleocapsid protein into IFN-I antagonists that enhance virus replication, suggesting that caspase-6 has a proviral role in the coronavirus life cycle.
Details
- Title: Subtitle
- Proviral role of caspase-6 in coronavirus infections
- Creators
- Lok-Yin Roy WongStanley Perlman
- Resource Type
- Journal article
- Publication Details
- Cell research, Vol.33, pp.7-8
- DOI
- 10.1038/s41422-022-00728-5
- PMID
- 36131099
- PMCID
- PMC9490723
- ISSN
- 1001-0602
- eISSN
- 1748-7838
- Grant note
- DOI: 10.13039/100000002, name: U.S. Department of Health & Human Services | National Institutes of Health, award: P01 060699, R01129269, AI170996; name: U.S. Department of Health & Human Services | National Institutes of Health; name: U.S. Department of Health & Human Services | National Institutes of Health
- Language
- English
- Electronic publication date
- 09/21/2022
- Date published
- 01/2023
- Academic Unit
- Microbiology and Immunology; Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Infectious Disease (Pediatrics)
- Record Identifier
- 9984296995902771
Metrics
9 Record Views