Proxy analysis of hospital admissions due to colorectal cancer and Schistosoma mansoni incidence

Gustavo Fernandes Godoy Almeida; Mauricio Assuero Lima de Freitas; Lais Neares Barbosa Ribeiro; Mariana Montenegro de Melo Lira; Maxwell Alex de Lima Moura; Lauro Vinicius Machado da Silva; Luiz Alberto Reis Mattos; Ana Lucia Coutinho Domingues

doi:10.5935/1806-6054.20180005

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Proxy analysis of hospital admissions due to colorectal cancer and Schistosoma mansoni incidence

Journal article

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Proxy analysis of hospital admissions due to colorectal cancer and Schistosoma mansoni incidence

Gustavo Fernandes Godoy Almeida, Mauricio Assuero Lima de Freitas, Lais Neares Barbosa Ribeiro, Mariana Montenegro de Melo Lira, Maxwell Alex de Lima Moura, Lauro Vinicius Machado da Silva, Luiz Alberto Reis Mattos and Ana Lucia Coutinho Domingues

Brazilian Journal of Oncology, Vol.14(49), pp.1-4

07/01/2018

DOI: 10.5935/1806-6054.20180005

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Abstract

ABSTRACT Schistosoma has been associated with colorectal cancer. We compared the number of colorectal cancer admissions between those cities in the state of Pernambuco with and without schistosomiasis. We abstracted data from Datasus and analyzed the number of admissions due to CRC in those cities with (CRC/Schistosoma) and without schistosomiasis (CRC-alone) in the State of Pernambuco and compared these numbers using odds ratio and relative risk at a significance level of 5%. This was preceded by an F test to reject the null hypothesis that the number of cities in each group was the same. The mean number of admissions due to CRC in CRC-Schistosoma cities was 94.55, with a variability of 366%, while in CRC-alone cities the mean was 11.06, with a variability of 88%. A test at a significance level of 5% rejected the hypothesis that these variances were the same (p-value, 0.0000). A subsequent test also rejected the null hypothesis that the mean of admissions was the same (two-sided p-value 0.0167). The state of Pernambuco encompasses 184 cities of which 103 registered schistosomiases (102 with colorectal cancer and 1 without). We compared the number of admissions due to CRC and/or due to schistosomiasis with admissions due to other diseases to measure the odds ratio for colorectal cancer due to schistosomiasis exposure. This comparison resulted in an OR of 2.657 (CI 95% 2,478-2,849) for CRC due to exposure to schistosomiasis. We found a statistically significant correlation between colorectal cancer admissions and schistosomiasis in the state of Pernambuco. Pharmacoeconomic studies might proof if investment to prevent nematode infestation would translate into cost spare with less admissions due to cancer and cancer treatments.

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Title: Subtitle: Proxy analysis of hospital admissions due to colorectal cancer and Schistosoma mansoni incidence
Creators: Gustavo Fernandes Godoy Almeida
Mauricio Assuero Lima de Freitas
Lais Neares Barbosa Ribeiro - Universidade Federal de Pernambuco
Mariana Montenegro de Melo Lira
Maxwell Alex de Lima Moura
Lauro Vinicius Machado da Silva
Luiz Alberto Reis Mattos - Hospital das Clínicas da Universidade Federal de Pernambuco
Ana Lucia Coutinho Domingues - Universidade Federal de Pernambuco
Resource Type: Journal article
Publication Details: Brazilian Journal of Oncology, Vol.14(49), pp.1-4
DOI: 10.5935/1806-6054.20180005
ISSN: 2526-8732
eISSN: 2526-8732
Publisher: Thieme Revinter Publicações Ltda
Number of pages: 4
Translated title: Análise proxy de internações por câncer colorretal e incidência de Schistosoma Mansoni
Language: English
Date published: 07/01/2018
Academic Unit: Hematology, Oncology, and Blood & Marrow Transplantation; Internal Medicine
Record Identifier: 9985150647802771

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