Journal article
Pseudodestruxins A and B: New Cyclic Depsipeptides from the Coprophilous Fungus Nigrosabulum globosum
Journal of natural products (Washington, D.C.), Vol.64(5), pp.555-558
05/25/2001
DOI: 10.1021/np000547r
PMID: 11374942
Abstract
Pseudodestruxins A (1) and B (2), two new cyclic peptides, have been isolated from cultures of the coprophilous fungus Nigrosabulum globosum. The structure of pseudodestruxin A (1) was elucidated using 2D NMR techniques and confirmed by single-crystal X-ray diffraction analysis. The structure of 2 was assigned by comparing its NMR and FABMS data with those of compound 1. The known compounds ascochlorin and 5-chlorocollectorin B were also isolated from N. globosum. Although 1 and 2 display antibacterial effects, ascochlorin was found to be responsible for the antifungal activity of the crude extract.
Details
- Title: Subtitle
- Pseudodestruxins A and B: New Cyclic Depsipeptides from the Coprophilous Fungus Nigrosabulum globosum
- Creators
- Yongsheng Che - Department of Chemistry, University of Iowa, Iowa City, Iowa 52242, and Department of Botany, University of Toronto,Toronto, Ontario M5S 1A1, CanadaDale C Swenson - Department of Chemistry, University of Iowa, Iowa City, Iowa 52242, and Department of Botany, University of Toronto,Toronto, Ontario M5S 1A1, CanadaJames B Gloer - Department of Chemistry, University of Iowa, Iowa City, Iowa 52242, and Department of Botany, University of Toronto,Toronto, Ontario M5S 1A1, CanadaBrenda Koster - Department of Chemistry, University of Iowa, Iowa City, Iowa 52242, and Department of Botany, University of Toronto,Toronto, Ontario M5S 1A1, CanadaDavid Malloch - Department of Chemistry, University of Iowa, Iowa City, Iowa 52242, and Department of Botany, University of Toronto,Toronto, Ontario M5S 1A1, Canada
- Resource Type
- Journal article
- Publication Details
- Journal of natural products (Washington, D.C.), Vol.64(5), pp.555-558
- Publisher
- American Chemical Society
- DOI
- 10.1021/np000547r
- PMID
- 11374942
- ISSN
- 0163-3864
- eISSN
- 1520-6025
- Language
- English
- Date published
- 05/25/2001
- Academic Unit
- Chemistry
- Record Identifier
- 9984216598702771
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