Journal article
Pseudosarcomatous fibroblastic/myofibroblastic proliferation in perinephric adipose tissue adjacent to renal cell carcinoma: a lesion mimicking well-differentiated liposarcoma
Modern pathology, Vol.22(9), pp.1196-1200
09/2009
DOI: 10.1038/modpathol.2009.84
PMID: 19525929
Abstract
Cytologically atypical stromal cells were found in the perinephric adipose tissue, mimicking well-differentiated liposarcoma in 12 of 59 (20%) consecutive nephrectomy specimens that were resected for renal cell carcinoma. Morphologically, the atypical cells included enlarged, hyperchromatic spindle cells and floret-type multinucleate cells. Of 59, 10 (17%) renal cell carcinomas invaded through the renal capsule into the perinephric adipose tissue. Of these cases, three (30%) contained the aforementioned atypical cells. In contrast, 9 of 49 cases without extrarenal invasion (18%) contained the atypical stromal cells. Of the 12 cases with atypical stromal cells, 3 (25%) were associated with extrarenal involvement. The atypical spindle cells exhibited focal to variable positivity for smooth muscle actin and desmin in 3 of the 14 cases (including two cases from our consultation files) each. Cytokeratin AE1/AE3, cytokeratin Cam 5.2, cytokeratin 7, epithelial membrane antigen, and S-100 were negative in all cases. Amplification of MDM2 gene region, which is commonly observed in well-differentiated liposarcoma, was absent by fluorescence in situ hybridization (FISH) in the atypical stromal cells. Immunohistochemistry and FISH suggest that the atypical cells are most consistent with reactive fibroblasts/myofibroblasts. Recognition of these atypical fibroblasts/myofibroblasts may help in avoiding the potential pitfall of misdiagnosing them as well-differentiated liposarcoma.
Details
- Title: Subtitle
- Pseudosarcomatous fibroblastic/myofibroblastic proliferation in perinephric adipose tissue adjacent to renal cell carcinoma: a lesion mimicking well-differentiated liposarcoma
- Creators
- Munir R Tanas - Department of Anatomic Pathology, Pathology and Laboratory Medicine Institute, The Cleveland Clinic and The Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, OH 44195, USAChalenpoj SthapanachaiDaisuke NonakaJonathan MelamedAndre M OliveiraMichele R Erickson-JohnsonBrian P Rubin
- Resource Type
- Journal article
- Publication Details
- Modern pathology, Vol.22(9), pp.1196-1200
- Publisher
- United States
- DOI
- 10.1038/modpathol.2009.84
- PMID
- 19525929
- ISSN
- 0893-3952
- eISSN
- 1530-0285
- Language
- English
- Date published
- 09/2009
- Academic Unit
- Pathology
- Record Identifier
- 9984047663602771
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