Journal article
Psoriasis and psoriatic arthritis following use of dostarlimab for endometrial cancer
BMJ case reports, Vol.17(8), pp.1-5
08/03/2024
DOI: 10.1136/bcr-2024-260426
PMID: 39097324
Abstract
Immune checkpoint inhibitors (ICIs) are associated with immune-related adverse events (irAEs), but psoriasis and psoriatic arthritis (PsA) after use of dostarlimab have not been reported. We present a woman who received dostarlimab for endometrial cancer and subsequently developed rash and polyarthralgia, diagnosed as overlapping palmoplantar pustular and plaque psoriasis with PsA. She was treated with discontinuation of dostarlimab, topical steroids, oral methylprednisolone and methotrexate. This case highlights phenotypic heterogeneity in cutaneous irAEs influenced by malignancy and ICI type and underscores the need for multidisciplinary care in treating irAEs. We review three current professional society guidelines for managing irAEs, highlighting their emphasis on management based on severity grading, early initiation of systemic corticosteroids and steroid-sparing agents and discontinuation of ICI for severe events. Certain recommendations deviate from typical approaches to idiopathic rheumatologic disease. Further research is needed to support the ongoing development of approaches to irAE management.
Details
- Title: Subtitle
- Psoriasis and psoriatic arthritis following use of dostarlimab for endometrial cancer
- Creators
- Anurag Ratan Goel - Brown UniversityCharity Sylvester - Brown UniversityOlivia Rose Avidan - Brown UniversityVinit Joseph Gilvaz - Brown University
- Resource Type
- Journal article
- Publication Details
- BMJ case reports, Vol.17(8), pp.1-5
- DOI
- 10.1136/bcr-2024-260426
- PMID
- 39097324
- ISSN
- 1757-790X
- eISSN
- 1757-790X
- Publisher
- Bmj Publishing Group
- Number of pages
- 5
- Language
- English
- Date published
- 08/03/2024
- Academic Unit
- Internal Medicine
- Record Identifier
- 9985237608602771
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