Psychiatric genome-wide association study analyses implicate neuronal, immune and histone pathways

Colm O'Dushlaine; Lizzy Rossin; Phil H. Lee; Laramie Duncan; Neelroop N. Parikshak; Stephen Newhouse; Stephan Ripke; Benjamin M. Neale; Shaun M. Purcell; Danielle Posthuma; John I. Nurnberger; S. Hong Lee; Stephen V. Faraone; Roy H. Perlis; Bryan J. Mowry; Anita Thapar; Michael E. Goddard; John S. Witte; Devin Absher; Ingrid Agartz; Huda Akil; Farooq Amin; Ole A. Andreassen; Adebayo Anjorin; Richard Anney; Verneri Anttila; Dan E. Arking; Philip Asherson; Maria H. Azevedo; Lena Backlund; Judith A. Badner; Anthony J. Bailey; Tobias Banaschewski; Jack D. Barchas; Michael R. Barnes; Thomas B. Barrett; Nicholas Bass; Agatino Battaglia; Michael Bauer; Monica Bayes; Frank Bellivier; Sarah E. Bergen; Wade Berrettini; Catalina Betancur; Thomas Bettecken; Joseph Biederman; Elisabeth B. Binder; Donald W. Black; Douglas H. R. Blackwood; Cinnamon S. Bloss; Michael Boehnke; Dorret I. Boomsma; Rene Breuer; Richard Bruggeman; Paul Cormican; Nancy G. Buccola; Jan K. Buitelaar; William E. Bunney; Joseph D. Buxbaum; William F. Byerley; Enda M. Byrne; Sian Caesar; Wiepke Cahn; Rita M. Cantor; Miguel Casas; Aravinda Chakravarti; Kimberly Chambert; Khalid Choudhury; Sven Cichon; Manuel Mattheisen; C. Robert Cloninger; David A. Collier; Edwin H. Cook; Hilary Coon; Bru Cormand; Aiden Corvin; William H. Coryell; David W. Craig; Ian W. Craig; Jennifer Crosbie; Michael L. Cuccaro; David Curtis; Darina Czamara; Susmita Datta; Geraldine Dawson; Richard Day; Eco J. De Geus; Franziska Degenhardt; Srdjan Djurovic; Gary J. Donohoe; Alysa E. Doyle; Jubao Duan; Frank Dudbridge; Eftichia Duketis; Richard P. Ebstein; Howard J. Edenberg; Josephine Elia; Sean Ennis; Bruno Etain; Ayman Fanous; Anne E. Farmer; I. Nicol Ferrier; Matthew Flicldnger; Eric Fombonne; Tatiana Foroud; Josef Frank; Barbara Franke; Christine Fraser; Robert Freedman; Nelson B. Freimer; Christine M. Freitag; Marion Friedl; Louise Frisen; Louise Gailagher; Pablo V. Gejman; Lyudmila Georgieva; Elliot S. Gershon; Ina Giegling; Michael Gill; Scott D. Gordon; Katherine Gordon-Smith; Elaine K. Green; Tiffany A. Greenwood; Dorothy E. Grice; Magdalena Gross; Detelina Grozeva; Weihua Guan; Hugh Gurling; Lieuwe De Haan; Jonathan L. Haines; Hakon Hakonarson; Joachim Hallmayer; Steven P. Hamilton; Marian L. Hamshere; Thomas F. Hansen; Annette M. Hartmann; Martin Hautzinger; Andrew C. Heath; Anjali K. Henders; Stefan Herms; Ian B. Hickie; Maria Hipolito; Susanne Hoefels; Florian Holsboer; Witte J. Hoogendijk; Jouke-Jan Hottenga; Christina M. Hultman; Vanessa Hus; Andres Ingason; Marcus Ising; Stephane Jamain; Edward G. Jones; Ian Jones; Lisa Jones; Jung-Ying Tzeng; Anna K. Kaehler; Rene S. Kahn; Radhika Kandaswamy; Matthew C. Keller; James L. Kennedy; Elaine Kenny; Lindsey Kent; Yunjung Kim; George K. Kirov; Sabine M. Klauck; Lambertus Klei; James A. Knowles; Martin A. Kohli; Daniel L. Koller; Bettina Konte; Ania Korszun; Lydia Krabbendam; Robert Krasucki; Jonna Kuntsi; Phoenix Kwan; Mikael Landen; Niklas Laengstroem; Mark Lathrop; Jacob Lawrence; William B. Lawson; Marion Leboyer; David H. Ledbetter; Todd Lencz; Klaus-Peter Lesch; Douglas F. Levinson; Cathryn M. Lewis; Jun Li; Paul Lichtenstein; Jeffrey A. Lieberman; Dan-Yu Lin; Don H. Linszen; Chunyu Liu; Falk W. Lohoff; Sandra K. Loo; Catherine Lord; Jennifer K. Lowe; Susanne Lucae; Donald J. MacIntyre; Pamela A. F. Madden; Elena Maestrini; Patrik K. E. Magnusson; Pamela B. Mahon; Wolfgang Maier; Anil K. Malhotra; Shrikant M. Mane; Christa L. Martin; Nicholas G. Martin; Keith Matthews; Morten Mattingsdal; Steven A. McCarroll; Kevin A. McGhee; James J. McGough; Patrick J. McGrath; Peter McGuffin; Melvin G. McInnis; Andrew McIntosh; Rebecca McKinney; Alan W. McLean; Francis J. McMahon; William M. McMahon; Andrew McQuillin; Helena Medeiros; Sarah E. Medland; Sandra Meier; Ingrid Melle; Fan Meng; Jobst Meyer; Christel M. Middeldorp; Lefkos Middleton; Vihra Milanova; Ana Miranda; Anthony P. Monaco; Grant W. Montgomery; Jennifer L. Moran; Daniel Moreno-De-Luca; Gunnar Morken; Derek W. Morris; Eric M. Morrow; Valentina Moskvina; Pierandrea Muglia; Thomas W. Muehleisen; Walter J. Muir; Bertram Mueller-Myhsok; Michael Murtha; Richard M. Myers; Inez Myin-Germeys; Michael C. Neale; Stan F. Nelson; Caroline M. Nievergelt; Ivan Nikolov; Vishwajit Nimgaonkar; Willem A. Nolen; Markus M. Noethen; Evaristus A. Nwulia; Dale R. Nyholt; Robert D. Oades; Ann Olincy; Guiomar Oliveira; Line Olsen; Roel A. Ophoff; Urban Osby; Michael J. Owen; Aarno Palotie; Jeremy R. Parr; Andrew D. Paterson; Carlos N. Pato; Michele T. Pato; Brenda W. Penninx; Michele L. Pergadia; Margaret A. Pericak-Vance; Benjamin S. Pickard; Jonathan Pimm; Joseph Piven; James B. Potash; Fritz Poustka; Peter Propping; Vinay Puri; Digby J. Quested; Emma M. Quinn; Josep Antoni Ramos-Quiroga; Henrik B. Rasmussen; Soumya Raychaudhuri; Karola Rehnstroem; Andreas Reif; Marta Ribases; John P. Rice; Marcella Rietschel; Kathryn Roeder; Herbert Roeyers; Aribert Rothenberger; Guy Rouleau; Douglas Ruderfer; Dan Rujescu; Alan R. Sanders; Stephan J. Sanders; Susan L. Santangelo; Joseph A. Sergeant; Russell Schachar; Martin Schalling; Alan F. Schatzberg; William A. Scheftner; Gerard D. Schellenberg; Stephen W Scherer; Nicholas J. Schork; Thomas G. Schulze; Johannes Schumacher; Markus Schwarz; Edward Scolnick; Laura J. Scott; Jianxin Shi; Paul D. Shilling; Stanley I. Shyn; Jeremy M. Silverman; Susan L. Slager; Susan L. Smalley; Johannes H. Smit; Erin N. Smith; Edmund J. S. Sonuga-Barke; David St Cair; Matthew State; Michael Steffens; Hans-Christoph Steinhausen; John S. Strauss; Jana Strohmaier; T. Scott Stroup; James S. Sutdiffe; Peter Szatmari; Szabocls Szelinger; Srinivasa Thirumalai; Robert C. Thompson; Alexandre A. Todorov; Federica Tozzi; Jens Treutlein; Manfred Uhr; Edwin J. C. G. Van den Oord; Gerard Van Grootheest; Jim Van Os; Astrid M. Vicente; Veronica J. Vieland; John B. Vincent; Peter M. Visscher; Christopher A. Walsh; Thomas H. Wassink; Stanley J. Watson; Myrna M. Weissman; Thomas Werge; Thomas F. Wienker; Ellen M. Wijsman; Gonneke Willemsen; Nigel Williams; A. Jeremy Willsey; Stephanie H. Witt; Wei Xu; Allan H. Young; Timothy W. Yu; Stanley Zammit; Peter P. Zandi; Peng Zhang; Frans G. Zitman; Sebastian Zoellner; Bernie Devlin; John R. Kelsoe; Pamela Sklar; Mark J. Daly; Michael C. O'Donovan; Nicholas Craddock; Kenneth S. Kendler; Lauren A. Weiss; Naomi R. Wray; Zhaoming Zhao; Daniel H. Geschwind; Patrick F. Sullivan; Jordan W. Smoller; Peter A. Holmans; Gerome Breen; Network and Pathway Analysis Subgroup of the Psychiatric Genomics Consortium

doi:10.1038/nn.3922

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Psychiatric genome-wide association study analyses implicate neuronal, immune and histone pathways

Journal article

Peer reviewed

Psychiatric genome-wide association study analyses implicate neuronal, immune and histone pathways

Colm O'Dushlaine, Lizzy Rossin, Phil H. Lee, Laramie Duncan, Neelroop N. Parikshak, Stephen Newhouse, Stephan Ripke, Benjamin M. Neale, Shaun M. Purcell, Danielle Posthuma, …

Nature neuroscience, Vol.18(2), pp.199-209

02/01/2015

DOI: 10.1038/nn.3922

PMCID: PMC4378867

PMID: 25599223

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Abstract

Genome-wide association studies (GWAS) of psychiatric disorders have identified multiple genetic associations with such disorders, but better methods are needed to derive the underlying biological mechanisms that these signals indicate. We sought to identify biological pathways in GWAS data from over 60,000 participants from the Psychiatric Genomics Consortium. We developed an analysis framework to rank pathways that requires only summary statistics. We combined this score across disorders to find common pathways across three adult psychiatric disorders: schizophrenia, major depression and bipolar disorder. Histone methylation processes showed the strongest association, and we also found statistically significant evidence for associations with multiple immune and neuronal signaling pathways and with the postsynaptic density. Our study indicates that risk variants for psychiatric disorders aggregate in particular biological pathways and that these pathways are frequently shared between disorders. Our results confirm known mechanisms and suggest several novel insights into the etiology of psychiatric disorders.

Life Sciences & Biomedicine

Neurosciences

Neurosciences & Neurology

Science & Technology

Details

Title: Subtitle: Psychiatric genome-wide association study analyses implicate neuronal, immune and histone pathways
Creators: Colm O'Dushlaine - Massachusetts Institute of Technology
Lizzy Rossin - Massachusetts Institute of Technology
Phil H. Lee - Harvard University
Laramie Duncan - Massachusetts Institute of Technology
Neelroop N. Parikshak - University of California, Los Angeles
Stephen Newhouse - King's College London
Stephan Ripke - Massachusetts Institute of Technology
Benjamin M. Neale - Massachusetts Institute of Technology
Shaun M. Purcell - Broad Institute
Danielle Posthuma - Vrije Universiteit Amsterdam
John I. Nurnberger - Indiana University – Purdue University Indianapolis
S. Hong Lee - The University of Queensland
Stephen V. Faraone - State University of New York
Roy H. Perlis - Massachusetts Institute of Technology
Bryan J. Mowry - The University of Queensland
Anita Thapar - Cardiff University
Michael E. Goddard - The University of Melbourne
John S. Witte - University of California, San Francisco
Devin Absher - HudsonAlpha Inst Biotechnol, Huntsville, AL USA
Ingrid Agartz - University of Oslo
Huda Akil - University of Michigan
Farooq Amin - Emory University
Ole A. Andreassen - University of Oslo
Adebayo Anjorin - University College London
Richard Anney - Trinity College Dublin
Verneri Anttila - Massachusetts Institute of Technology
Dan E. Arking - Johns Hopkins University
Philip Asherson - King's College London
Maria H. Azevedo - Univ Coimbra, Fac Med, Coimbra, Portugal
Lena Backlund - Karolinska Institutet
Judith A. Badner - University of Chicago
Anthony J. Bailey - University of British Columbia
Tobias Banaschewski - Heidelberg University
Jack D. Barchas - Cornell University
Michael R. Barnes - GlaxoSmithKline (United Kingdom)
Thomas B. Barrett - Portland VA Medical Center
Nicholas Bass - University College London
Agatino Battaglia - Stella Maris Inst Child & Adolescent Neuropsychia, Pisa, Italy
Michael Bauer - Technische Universität Dresden
Monica Bayes - CNAG, PCB, Barcelona, Spain
Frank Bellivier - Inserm
Sarah E. Bergen - Massachusetts Gen Hosp, Psychiat & Neurodevelopmental Genet Unit, Boston, MA 02114 USA
Wade Berrettini - University of Pennsylvania
Catalina Betancur - Inserm
Thomas Bettecken - Max Planck Society
Joseph Biederman - Harvard University
Elisabeth B. Binder - Max Planck Society
Donald W. Black - University of Iowa
Douglas H. R. Blackwood - Univ Edinburgh, Royal Edinburgh Hosp, Div Psychiat, Edinburgh, Midlothian, Scotland
Cinnamon S. Bloss - Scripps Research Institute
Michael Boehnke - University of Michigan
Dorret I. Boomsma - University of Amsterdam
Rene Breuer - Heidelberg University
Richard Bruggeman - Univ Groningen, Univ Med Ctr Groningen, Dept Psychiat, Groningen, Netherlands
Paul Cormican - Trinity College Dublin
Nancy G. Buccola - Louisiana State University Health Sciences Center New Orleans
Jan K. Buitelaar - Radboud University Nijmegen
William E. Bunney - University of California, Irvine
Joseph D. Buxbaum - Icahn School of Medicine at Mount Sinai
William F. Byerley - University of California, San Francisco
Enda M. Byrne - The University of Queensland
Sian Caesar - University of Birmingham
Wiepke Cahn - Utrecht University
Rita M. Cantor - University of California, Los Angeles
Miguel Casas - Universitat Autònoma de Barcelona
Aravinda Chakravarti - Johns Hopkins University
Kimberly Chambert - Harvard University
Khalid Choudhury - University College London
Sven Cichon - University of Basel
Manuel Mattheisen - Lundbeck (United States)
C. Robert Cloninger - University of Washington
David A. Collier - King's College London
Edwin H. Cook - University of Illinois Chicago
Hilary Coon - Utah System of Higher Education
Bru Cormand - Universitat de Barcelona
Aiden Corvin - Trinity College Dublin
William H. Coryell - University of Iowa
David W. Craig - Translational Genomics Research Institute
Ian W. Craig - King's College London
Jennifer Crosbie - University of Toronto
Michael L. Cuccaro - University of Miami
David Curtis - University of London
Darina Czamara - Max Planck Society
Susmita Datta - University College London
Geraldine Dawson - University of North Carolina at Chapel Hill
Richard Day - University of Dundee
Eco J. De Geus - University of Amsterdam
Franziska Degenhardt - University of Bonn
Srdjan Djurovic - University of Oslo
Gary J. Donohoe - Trinity College Dublin
Alysa E. Doyle - Harvard University
Jubao Duan - University of Chicago
Frank Dudbridge - University of London
Eftichia Duketis - Goethe University Frankfurt
Richard P. Ebstein - National University of Singapore
Howard J. Edenberg - Indiana University – Purdue University Indianapolis
Josephine Elia - University of Pennsylvania
Sean Ennis - University College Dublin
Bruno Etain - Inserm
Ayman Fanous - Georgetown University
Anne E. Farmer - Massachusetts Rehabilitation Commission
I. Nicol Ferrier - Newcastle Univ, Inst Neurosci, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England
Matthew Flicldnger - Univ Michigan, Sch Publ Hlth, Dept Biostat, Ann Arbor, MI 48109 USA
Eric Fombonne - Oregon Hlth & Sci Univ, Dept Psychiat, Portland, OR 97201 USA
Tatiana Foroud - University of California, San Francisco
Josef Frank - Heidelberg Univ, Med Fac Mannheim, Cent Inst Mental Hlth, Dept Genet Epidemiol Psychiat, Mannheim, Germany
Barbara Franke - Radboud University Nijmegen
Christine Fraser - Cardiff University
Robert Freedman - Univ Colorado Denver, Dept Psychiat, Aurora, CO USA
Nelson B. Freimer - Univ Calif Los Angeles, Ctr Neurobehav Genet, Los Angeles, CA USA
Christine M. Freitag - Goethe University Frankfurt
Marion Friedl - Univ Halle, Dept Psychiat, Halle, Germany
Louise Frisen - Karolinska Institutet
Louise Gailagher - Trin Coll Dublin, Dept Psychiat, Dublin, Ireland
Pablo V. Gejman - NorthShore Univ Hlth Syst, Dept Psychiat & Behav Sci, Evanston, IL USA
Lyudmila Georgieva - Cardiff University
Elliot S. Gershon - Univ Chicago, Dept Psychiat, Chicago, IL 60637 USA
Ina Giegling - Univ Halle, Dept Psychiat, Halle, Germany
Michael Gill - Trin Coll Dublin, Dept Psychiat, Dublin, Ireland
Scott D. Gordon - Queensland Inst Med Res, Brisbane, Qld 4006, Australia
Katherine Gordon-Smith - Cardiff University
Elaine K. Green - Univ Plymouth, Dept Biomed & Biol Sci, Plymouth PL4 8AA, Devon, England
Tiffany A. Greenwood - Univ Calif San Diego, Dept Psychiat, La Jolla, CA 92093 USA
Dorothy E. Grice - Icahn School of Medicine at Mount Sinai
Magdalena Gross - Univ Bonn, Dept Psychiat, Bonn, Germany
Detelina Grozeva - Cardiff University
Weihua Guan - Univ Michigan, Sch Publ Hlth, Dept Biostat, Ann Arbor, MI 48109 USA
Hugh Gurling - UCL, Mental Hlth Sci Unit, London, England
Lieuwe De Haan - Univ Amsterdam, Acad Med Ctr, Dept Psychiat, NL-1105 AZ Amsterdam, Netherlands
Jonathan L. Haines - Vanderbilt University
Hakon Hakonarson - Childrens Hosp Philadelphia, Ctr Appl Gen, Div Human, Philadelphia, PA 19104 USA
Joachim Hallmayer - Stanford University
Steven P. Hamilton - Univ Calif San Francisco, Dept Psychiat, San Francisco, CA 94143 USA
Marian L. Hamshere - Univ Tubingen, Dept Clin & Dev Psychol, Tubingen, Germany
Thomas F. Hansen - iPSYCH, Lundbeck Initiat Integrat Psychiat Res, Roskilde, Denmark
Annette M. Hartmann - Univ Halle, Dept Psychiat, Halle, Germany
Martin Hautzinger - Univ Tubingen, Dept Clin & Dev Psychol, Tubingen, Germany
Andrew C. Heath - Washington University in St. Louis
Anjali K. Henders - Queensland Inst Med Res, Brisbane, Qld 4006, Australia
Stefan Herms - Life & Brain (Germany)
Ian B. Hickie - MIND Research Institute
Maria Hipolito - Howard University
Susanne Hoefels - Univ Bonn, Dept Psychiat, Bonn, Germany
Florian Holsboer - Max Planck Institute of Psychiatry
Witte J. Hoogendijk - Erasmus MC, Dept Psychiat, Rotterdam, Netherlands
Jouke-Jan Hottenga - Vrije Univ Amsterdam, Dept Biol Psychol, Amsterdam, Netherlands
Christina M. Hultman - Karolinska Institutet
Vanessa Hus - Univ Michigan, Dept Psychol, Ann Arbor, MI 48109 USA
Andres Ingason - iPSYCH, Lundbeck Initiat Integrat Psychiat Res, Roskilde, Denmark
Marcus Ising - Max Planck Institute of Psychiatry
Stephane Jamain - Inserm
Edward G. Jones - iPSYCH, Lundbeck Initiat Integrat Psychiat Res, Roskilde, Denmark
Ian Jones - Cardiff University
Lisa Jones - Univ Birmingham, Dept Psychiat, Birmingham, W Midlands, England
Jung-Ying Tzeng - N Carolina State Univ, Bioinformat Res Ctr, Raleigh, NC 27695 USA
Anna K. Kaehler - Karolinska Institutet
Rene S. Kahn - Univ Med Ctr, Rudolf Magnus Inst Neurosci, Utrecht Psychiat, Dept Psychiat, Birmingham, W Midlands, England
Radhika Kandaswamy - UCL, Mental Hlth Sci Unit, London, England
Matthew C. Keller - Univ Colorado, Dept Psychol, Boulder, CO 80309 USA
James L. Kennedy - Ctr Addict & Mental Hlth, Psychiat Neurogenet Sect, Toronto, ON, Canada
Elaine Kenny - Trin Coll Dublin, Dept Psychiat, Dublin, Ireland
Lindsey Kent - University of St Andrews
Yunjung Kim - Univ N Carolina, Dept Genet, Chapel Hill, NC USA
George K. Kirov - Cardiff University
Sabine M. Klauck - German Cancer Research Center
Lambertus Klei - University of Pittsburgh
James A. Knowles - University of Pittsburgh
Martin A. Kohli - Max Planck Institute of Psychiatry
Daniel L. Koller - University of California, San Francisco
Bettina Konte - Univ Halle, Dept Psychiat, Halle, Germany
Ania Korszun - Queen Mary Univ London, Wolfson Inst Preventat Med, London, England
Lydia Krabbendam - Maastricht University
Robert Krasucki - UCL, Mental Hlth Sci Unit, London, England
Jonna Kuntsi - Massachusetts Rehabilitation Commission
Phoenix Kwan - Univ Michigan, Sch Publ Hlth, Dept Biostat, Ann Arbor, MI 48109 USA
Mikael Landen - Karolinska Institutet
Niklas Laengstroem - Karolinska Institutet
Mark Lathrop
Jacob Lawrence - UCL, Mental Hlth Sci Unit, London, England
William B. Lawson - Howard University
Marion Leboyer - Inserm
David H. Ledbetter - Geisinger Health System
Todd Lencz - Zucker Hillside Hosp Div North Shore, Dept Psychiat, Div Res, Glen Oaks, NY USA
Klaus-Peter Lesch - Univ Wurzburg, ADHD Clin Res Unit, Dept Psychiat Psychosomat & Psychotherapy, Div Mol Psychiat, D-97070 Wurzburg, Germany
Douglas F. Levinson - Stanford University
Cathryn M. Lewis - Massachusetts Rehabilitation Commission
Jun Li - Univ Michigan, Dept Human Genet, Ann Arbor, MI 48109 USA
Paul Lichtenstein - Karolinska Institutet
Jeffrey A. Lieberman - Columbia University
Dan-Yu Lin - University of North Carolina at Chapel Hill
Don H. Linszen - Univ Amsterdam, Acad Med Ctr, Dept Psychiat, NL-1105 AZ Amsterdam, Netherlands
Chunyu Liu - Univ Illinois, Inst Human Genet, Dept Psychiat, Chicago, IL USA
Falk W. Lohoff - Univ Penn, Dept Psychiat, Philadelphia, PA 19104 USA
Sandra K. Loo - Univ Calif Los Angeles, Ctr Neurobehav Genet, Los Angeles, CA USA
Catherine Lord - Weill Cornell Med Coll, Ctr Autism & Developing Brain, White Plains, NY USA
Jennifer K. Lowe - David Geffen School of Medicine at UCLA
Susanne Lucae - Max Planck Institute of Psychiatry
Donald J. MacIntyre - Univ Edinburgh, Royal Edinburgh Hosp, Div Psychiat, Edinburgh, Midlothian, Scotland
Pamela A. F. Madden - Washington University in St. Louis
Elena Maestrini - Univ Bologna, Dept Pharm & Biotechnol, Bologna, Italy
Patrik K. E. Magnusson - Karolinska Institutet
Pamela B. Mahon - Johns Hopkins University
Wolfgang Maier - Univ Bonn, Dept Psychiat, Bonn, Germany
Anil K. Malhotra - Zucker Hillside Hosp Div North Shore, Dept Psychiat, Div Res, Glen Oaks, NY USA
Shrikant M. Mane - Yale Ctr Genome Anal, Orange, CA USA
Christa L. Martin - Geisinger Health System
Nicholas G. Martin - Queensland Inst Med Res, Brisbane, Qld 4006, Australia
Keith Matthews - University of Dundee
Morten Mattingsdal - Univ Oslo, Inst Clin Med, KG Jebsen Ctr Psychosis Res, Oslo, Norway
Steven A. McCarroll - Massachusetts Gen Hosp, Analyt & Translat Genet Unit, Boston, MA 02114 USA
Kevin A. McGhee - Univ Edinburgh, Royal Edinburgh Hosp, Div Psychiat, Edinburgh, Midlothian, Scotland
James J. McGough - David Geffen School of Medicine at UCLA
Patrick J. McGrath - Columbia University
Peter McGuffin - Massachusetts Rehabilitation Commission
Melvin G. McInnis - Univ Michigan, Dept Psychiat, Ann Arbor, MI 48109 USA
Andrew McIntosh - Univ Edinburgh, Royal Edinburgh Hosp, Div Psychiat, Edinburgh, Midlothian, Scotland
Rebecca McKinney - Univ Calif San Diego, Dept Psychiat, La Jolla, CA 92093 USA
Alan W. McLean - Univ Edinburgh, Royal Edinburgh Hosp, Div Psychiat, Edinburgh, Midlothian, Scotland
Francis J. McMahon - US Natl Inst Hlth Bethesda, Nat Inst Mental Hlth, Bethesda, MD USA
William M. McMahon - Univ Utah, Dept Psychiat, Salt Lake City, UT USA
Andrew McQuillin - UCL, Mental Hlth Sci Unit, London, England
Helena Medeiros - University of Southern California
Sarah E. Medland - Queensland Inst Med Res, Brisbane, Qld 4006, Australia
Sandra Meier - Heidelberg Univ, Med Fac Mannheim, Cent Inst Mental Hlth, Dept Genet Epidemiol Psychiat, Mannheim, Germany
Ingrid Melle - Univ Oslo, Inst Clin Med, KG Jebsen Ctr Psychosis Res, Oslo, Norway
Fan Meng - Univ Michigan, Mol & Behav Neurosci Inst, Mol Psychiat Lab, Ann Arbor, MI 48109 USA
Jobst Meyer - Univ Trier, Dept Neurobehav Genet, Trier, Germany
Christel M. Middeldorp - Vrije Univ Amsterdam, Dept Biol Psychol, Amsterdam, Netherlands
Lefkos Middleton - Imperial College London
Vihra Milanova - Alexander Univ Hosp, Psychiat Clin 1, Dept Psychiat, Sofia, Bulgaria
Ana Miranda - Univ Valencia, Dept Dev & Educ Psychol, Valencia, Spain
Anthony P. Monaco - Wellcome Trust
Grant W. Montgomery - Queensland Inst Med Res, Brisbane, Qld 4006, Australia
Jennifer L. Moran - Massachusetts Gen Hosp, Analyt & Translat Genet Unit, Boston, MA 02114 USA
Daniel Moreno-De-Luca - Yale University
Gunnar Morken - St Olavs Hosp, Dept Psychiat, Trondheim, Norway
Derek W. Morris - Trin Coll Dublin, Dept Psychiat, Dublin, Ireland
Eric M. Morrow - Brown University
Valentina Moskvina - Cardiff University
Pierandrea Muglia - GlaxoSmithKline (Belgium)
Thomas W. Muehleisen - Life & Brain (Germany)
Walter J. Muir - Univ Edinburgh, Royal Edinburgh Hosp, Div Psychiat, Edinburgh, Midlothian, Scotland
Bertram Mueller-Myhsok - Max Planck Institute of Psychiatry
Michael Murtha - Yale University
Richard M. Myers - HudsonAlpha Inst Biotechnol, Huntsville, AL USA
Inez Myin-Germeys - Maastricht University
Michael C. Neale - Virginia Commonwealth University
Stan F. Nelson - Univ Calif Los Angeles, Ctr Neurobehav Genet, Los Angeles, CA USA
Caroline M. Nievergelt - Univ Calif San Diego, Dept Psychiat, La Jolla, CA 92093 USA
Ivan Nikolov - Cardiff University
Vishwajit Nimgaonkar - Univ Pittsburgh, Dept Psychiat, Pittsburgh, PA USA
Willem A. Nolen - Univ Groningen, Univ Med Ctr Groningen, Dept Psychiat, Groningen, Netherlands
Markus M. Noethen - Life & Brain (Germany)
Evaristus A. Nwulia - Howard University
Dale R. Nyholt - Queensland Inst Med Res, Brisbane, Qld 4006, Australia
Robert D. Oades - Univ Duisburg Essen, Clin Child & Adolescent Psychiat & Psychotherapy, Essen, Germany
Ann Olincy - Univ Colorado Denver, Dept Psychiat, Aurora, CO USA
Guiomar Oliveira - Univ Coimbra, Fac Med, Coimbra, Portugal
Line Olsen - iPSYCH, Lundbeck Initiat Integrat Psychiat Res, Roskilde, Denmark
Roel A. Ophoff - Univ Calif Los Angeles, Ctr Neurobehav Genet, Los Angeles, CA USA
Urban Osby - Karolinska Institutet
Michael J. Owen - Cardiff University
Aarno Palotie - Sanger Inst, Cambridge, England
Jeremy R. Parr - Newcastle Univ, Inst Neurosci, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England
Andrew D. Paterson - Hospital for Sick Children
Carlos N. Pato - University of Southern California
Michele T. Pato - University of Southern California
Brenda W. Penninx - Inst Hlth & Care Res, EMGO, Amsterdam, Netherlands
Michele L. Pergadia - Washington University in St. Louis School of Medicine
Margaret A. Pericak-Vance - Univ Miami, John P Hussman Inst Human Gen, Miami, FL USA
Benjamin S. Pickard - Univ Edinburgh, Royal Edinburgh Hosp, Div Psychiat, Edinburgh, Midlothian, Scotland
Jonathan Pimm - UCL, Mental Hlth Sci Unit, London, England
Joseph Piven - Univ N Carolina, Carolina Inst Dev Disabil, Chapel Hill, NC USA
James B. Potash - Univ Iowa, Dept Psychiat, Iowa City, IA 52242 USA
Fritz Poustka - Goethe University Frankfurt
Peter Propping - Univ Bonn, Inst Human Genet, Bonn, Germany
Vinay Puri - UCL, Mental Hlth Sci Unit, London, England
Digby J. Quested - Univ Oxford, Acad Dept Psychiat, Oxford, England
Emma M. Quinn - Trin Coll Dublin, Dept Psychiat, Dublin, Ireland
Josep Antoni Ramos-Quiroga - Hosp Univ Vail Hebron, CIBERSAM, Ctr Invest Biomed Area Salud Mental, Barcelona, Spain
Henrik B. Rasmussen - iPSYCH, Lundbeck Initiat Integrat Psychiat Res, Roskilde, Denmark
Soumya Raychaudhuri - Broad Institute
Karola Rehnstroem - Sanger Inst, Cambridge, England
Andreas Reif - Univ Wurzburg, Dept Psychiat, Wurzburg, Germany
Marta Ribases - Univ Bonn, Inst Human Genet, Bonn, Germany
John P. Rice - Washington University in St. Louis School of Medicine
Marcella Rietschel
Kathryn Roeder - Carnegie Mellon Univ, Dept Stat, Pittsburgh, PA 15213 USA
Herbert Roeyers - Univ Ghent, Dept Expt Clin & Hlth Psychol, B-9000 Ghent, Belgium
Aribert Rothenberger - Univ Med Gottingen, Gottingen, Germany
Guy Rouleau - McGill University
Douglas Ruderfer - Icahn School of Medicine at Mount Sinai
Dan Rujescu - Univ Halle, Dept Psychiat, Halle, Germany
Alan R. Sanders - NorthShore Univ Hlth Syst, Dept Psychiat & Behav Sci, Evanston, IL USA
Stephan J. Sanders - Yale University
Susan L. Santangelo - Maine Med Ctr, Dept Psychiat, Portland, ME 04102 USA
Joseph A. Sergeant - Vrije Univ Amsterdam, Dept Clin Neurophysiol, Amsterdam, Netherlands
Russell Schachar - Hospital for Sick Children
Martin Schalling - Karolinska Institutet
Alan F. Schatzberg - Stanford University
William A. Scheftner - Rush University
Gerard D. Schellenberg - Univ Penn, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA
Stephen W Scherer - Hospital for Sick Children
Nicholas J. Schork - Scripps Translat Sci Inst, La Jolla, CA USA
Thomas G. Schulze - Johns Hopkins University
Johannes Schumacher - Univ Bonn, Inst Human Genet, Bonn, Germany
Markus Schwarz - Psychiat Ctr Nordbaden, Wiesloch, Germany
Edward Scolnick - Massachusetts Gen Hosp, Analyt & Translat Genet Unit, Boston, MA 02114 USA
Laura J. Scott - Univ Michigan, Sch Publ Hlth, Dept Biostat, Ann Arbor, MI 48109 USA
Jianxin Shi - Natl Canc Inst, Div Canc Epidemiol & Genet, Bethesda, MD USA
Paul D. Shilling - Univ Calif San Diego, Dept Psychiat, La Jolla, CA 92093 USA
Stanley I. Shyn - Univ Washington, Dept Psychiat & Behav Sci, Seattle, WA 98195 USA
Jeremy M. Silverman - Icahn School of Medicine at Mount Sinai
Susan L. Slager - Mayo Clin, Rochester, MN USA
Susan L. Smalley - Univ Calif Los Angeles, Ctr Neurobehav Genet, Los Angeles, CA USA
Johannes H. Smit - Inst Hlth & Care Res, EMGO, Amsterdam, Netherlands
Erin N. Smith - Scripps Translat Sci Inst, La Jolla, CA USA
Edmund J. S. Sonuga-Barke - Univ Ghent, Dept Expt Clin & Hlth Psychol, B-9000 Ghent, Belgium
David St Cair - Univ Aberdeen, Inst Med Sci, Aberdeen, Scotland
Matthew State - Yale University
Michael Steffens - Federal Institute for Drugs and Medical Devices
Hans-Christoph Steinhausen - Aalborg University
John S. Strauss - Ctr Addict & Mental Hlth, Mol Neuropsychiat & Dev Lab, Toronto, ON, Canada
Jana Strohmaier - Heidelberg Univ, Med Fac Mannheim, Cent Inst Mental Hlth, Dept Genet Epidemiol Psychiat, Mannheim, Germany
T. Scott Stroup - Columbia University
James S. Sutdiffe - Vanderbilt University
Peter Szatmari - Univ Toronto, Dept Psychiat, Toronto, ON, Canada
Szabocls Szelinger - Translat Genom Res Inst, Phoenix, AZ USA
Srinivasa Thirumalai - Oxford Hlth NHS Fdn Trust, Marlborough House Secure Unit, Milton Keynes, Bucks, England
Robert C. Thompson - Univ Michigan, Mol & Behav Neurosci Inst, Mol Psychiat Lab, Ann Arbor, MI 48109 USA
Alexandre A. Todorov - Washington University in St. Louis School of Medicine
Federica Tozzi - GlaxoSmithKline Res & Dev Ltd, Neurosci Ctr Excellence Drug Discovery, Verona, Italy
Jens Treutlein - Heidelberg Univ, Med Fac Mannheim, Cent Inst Mental Hlth, Dept Genet Epidemiol Psychiat, Mannheim, Germany
Manfred Uhr - Max Planck Institute of Psychiatry
Edwin J. C. G. Van den Oord - Virginia Commonwealth University
Gerard Van Grootheest - Inst Hlth & Care Res, EMGO, Amsterdam, Netherlands
Jim Van Os - Maastricht University
Astrid M. Vicente - BioFIG, Ctr Biodivers, Funct & Integrat Gen, Lisbon, Portugal
Veronica J. Vieland - Nationwide Children's Hospital
John B. Vincent - Columbia University
Peter M. Visscher - Trin Coll Dublin, Dept Psychiat, Dublin, Ireland
Christopher A. Walsh - Boston Children's Hospital
Thomas H. Wassink - Univ Iowa, Dept Psychiat, Iowa City, IA 52242 USA
Stanley J. Watson - Univ Michigan, Mol & Behav Neurosci Inst, Mol Psychiat Lab, Ann Arbor, MI 48109 USA
Myrna M. Weissman - Columbia University
Thomas Werge - Lundbeck (Denmark)
Thomas F. Wienker - Univ Bonn, Inst Med Biometry, Bonn, Germany
Ellen M. Wijsman - University of Washington
Gonneke Willemsen - Vrije Univ Amsterdam, Dept Biol Psychol, Amsterdam, Netherlands
Nigel Williams - Cardiff University
A. Jeremy Willsey - Yale University
Stephanie H. Witt - Heidelberg Univ, Med Fac Mannheim, Cent Inst Mental Hlth, Dept Genet Epidemiol Psychiat, Mannheim, Germany
Wei Xu - University of Toronto
Allan H. Young - Newcastle Univ, Inst Neurosci, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England
Timothy W. Yu - Harvard University
Stanley Zammit - Cardiff University
Peter P. Zandi - Johns Hopkins University
Peng Zhang - University of Michigan
Frans G. Zitman - Leiden University
Sebastian Zoellner - Univ Michigan, Sch Publ Hlth, Dept Biostat, Ann Arbor, MI 48109 USA
Bernie Devlin - University of Pittsburgh
John R. Kelsoe - Univ Calif San Diego, Dept Psychiat, La Jolla, CA 92093 USA
Pamela Sklar - Cardiff University
Mark J. Daly - Broad Institute
Michael C. O'Donovan - Cardiff University
Nicholas Craddock - Cardiff University
Kenneth S. Kendler - Virginia Commonwealth University
Lauren A. Weiss - Univ Calif San Francisco, Dept Psychiat, San Francisco, CA 94143 USA
Naomi R. Wray - Univ Queensland, Queensland Brain Inst, Brisbane, Qld, Australia
Zhaoming Zhao - Vanderbilt University
Daniel H. Geschwind - David Geffen School of Medicine at UCLA
Patrick F. Sullivan - Univ N Carolina, Dept Genet, Chapel Hill, NC USA
Jordan W. Smoller - Massachusetts Gen Hosp, Psychiat & Neurodevelopmental Genet Unit, Boston, MA 02114 USA
Peter A. Holmans - Cardiff University
Gerome Breen - Massachusetts Rehabilitation Commission
Network and Pathway Analysis Subgroup of the Psychiatric Genomics Consortium
Resource Type: Journal article
Publication Details: Nature neuroscience, Vol.18(2), pp.199-209
DOI: 10.1038/nn.3922
PMID: 25599223
PMCID: PMC4378867
NLM abbreviation: Nat Neurosci
ISSN: 1097-6256
eISSN: 1546-1726
Publisher: Springer Nature
Number of pages: 11
Grant note: MR/L010305/1 / Medical Research Council; UK Research & Innovation (UKRI); Medical Research Council UK (MRC); European Commission Dutch Brain Foundation National Institute for Health Research (NIHR) Mental Health Biomedical Research Centre at South London; National Institute for Health Research (NIHR) K99MH101367 / US National Institute of Mental Health (NIMH); United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Mental Health (NIMH) King's College London G1000708 / MRC; UK Research & Innovation (UKRI); Medical Research Council UK (MRC) 480-05-003 / Netherlands Scientific Organization (NOW) R01GM047845 / NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of General Medical Sciences (NIGMS) U01 MH085520 / NIMH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Mental Health (NIMH) U01MH094432 / NATIONAL INSTITUTE OF MENTAL HEALTH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Mental Health (NIMH) R01CA082659 / NATIONAL CANCER INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI) Maudsley NHS Foundation Trust R155-2014-1724 / Lundbeck Foundation; Lundbeckfonden VU University
Language: English
Date published: 02/01/2015
Academic Unit: Psychiatry; Stead Family Department of Pediatrics
Record Identifier: 9984281750802771

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