Journal article
Psychobiological stress response to a lung cancer diagnosis: a prospective study of patients in Iceland and Sweden
Acta oncologica, Vol.62(10), pp.1338-1347
10/03/2023
DOI: 10.1080/0284186X.2023.2258445
Abstract
Background
A diagnostic work-up leading to a lung cancer diagnosis is a severely stressful experience that may impact tumor progression. Yet, prospective data are scarce on psychological and biological components of stress at the time of lung cancer diagnosis. The aim of this study was to assess pre-to-post diagnosis change in psychological distress and urinary excretion of catecholamines in patients with suspected lung cancer.
Methods
Participants were 167 patients within the LUCASS study, recruited at referral for suspected lung cancer to University Hospitals in Iceland and Sweden. Patients completed questionnaires on perceived distress (Hospital Anxiety and Depression Scale, HADS) before and after diagnosis of lung cancer or a non-malignant origin. A subpopulation of 85 patients also provided overnight urine for catecholamine analysis before and at a median of 24 days after diagnosis but before treatment.
Results
A lung cancer diagnosis was confirmed in 123 (73.7%) patients, with a mean age of 70.1 years. Patients diagnosed with lung cancer experienced a post-diagnosis increase in psychological distress (p = 0.010), while patients with non-malignant lung pathology showed a reduction in distress (p = 0.070). Both urinary epinephrine (p = 0.001) and norepinephrine (p = 0.032) levels were higher before the diagnosis among patients eventually diagnosed with lung cancer compared to those with non-malignant lung pathology. We observed indications of associations between pre-to-post diagnosis changes in perceived distress and changes in urinary catecholamine levels.
Conclusion
Receiving a lung cancer diagnosis is associated with an increase in psychological distress, while elevated catecholamine levels are evident already before lung cancer diagnosis.
Details
- Title: Subtitle
- Psychobiological stress response to a lung cancer diagnosis: a prospective study of patients in Iceland and Sweden
- Creators
- Hronn Hardardottir - University of IcelandThor Aspelund - University of IcelandKatja Fall - Örebro UniversityErika Broström - Uppsala UniversityBaldur B. Sigurdsson - Reykjavík UniversityElizabeth Cook - Reykjavík UniversityHeiddis Valdimarsdottir - Reykjavík UniversityFang Fang - Karolinska InstitutetErica K. Sloan - Monash UniversitySusan K. Lutgendorf - University of IowaChrister Jansson - Uppsala UniversityUnnur A. Valdimarsdottir - University of Iceland
- Resource Type
- Journal article
- Publication Details
- Acta oncologica, Vol.62(10), pp.1338-1347
- DOI
- 10.1080/0284186X.2023.2258445
- ISSN
- 0284-186X
- eISSN
- 1651-226X
- Grant note
- name: the Rannis Research Fund, award: 141667-051; DOI: 10.13039/100012538, name: the Swedish Cancer Foundation, award: 16 0720; name: the Doctoral Grant from the University of Iceland Research Fund/Eimskip University Fund2018, ; name: the Landspitali University Hospital Research Fund 2015
- Language
- English
- Electronic publication date
- 09/25/2023
- Date published
- 10/03/2023
- Academic Unit
- Psychological and Brain Sciences; Iowa Neuroscience Institute; Obstetrics and Gynecology; Urology
- Record Identifier
- 9984472656902771
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