Psychological and Pain Sensitization Characteristics Are Associated With Patellofemoral Osteoarthritis Symptoms: The Multicenter Osteoarthritis Study

Natalie J Collins; Tuhina Neogi; Bill Vicenzino; Ali Guermazi; Frank W Roemer; Cora E Lewis; James C Torner; Michael C Nevitt; Joshua J Stefanik

doi:10.3899/jrheum.190981

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Psychological and Pain Sensitization Characteristics Are Associated With Patellofemoral Osteoarthritis Symptoms: The Multicenter Osteoarthritis Study

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Psychological and Pain Sensitization Characteristics Are Associated With Patellofemoral Osteoarthritis Symptoms: The Multicenter Osteoarthritis Study

Natalie J Collins, Tuhina Neogi, Bill Vicenzino, Ali Guermazi, Frank W Roemer, Cora E Lewis, James C Torner, Michael C Nevitt and Joshua J Stefanik

Journal of rheumatology, Vol.47(11), pp.1696-1703

11/01/2020

DOI: 10.3899/jrheum.190981

PMCID: PMC8005266

PMID: 32115429

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https://www.ncbi.nlm.nih.gov/pmc/articles/8005266View

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Abstract

Determine the relation of symptomatic and structural features of patellofemoral osteoarthritis (PFOA) to psychological characteristics and measures of pain sensitization, in older adults with or at risk of knee osteoarthritis (OA). This study included 1112 participants from the Multicenter Osteoarthritis Study (713 females, mean age 66.8 ± SD 7.6 yrs, body mass index 29.5 ± 4.8 kg/m ). Participants were grouped based on the presence of PFOA symptoms (anterior knee pain and pain on stairs) and magnetic resonance imaging (MRI) PFOA (full-thickness cartilage lesion with bone marrow lesion): (1) patellofemoral (PF) symptoms with MRI PFOA; (2) PF symptoms without MRI PFOA; (3) MRI PFOA without PF symptoms; and (4) no PF symptoms or MRI PFOA (no PFOA). Relation of PFOA classification to depressive symptoms, catastrophizing, temporal summation (TS) and pressure pain thresholds (PPT) was evaluated using logistic (categorical variables) and linear regression (continuous variables). Compared with no PFOA, those with PF symptoms with or without MRI PFOA had significantly greater odds of depressive symptoms, catastrophizing, and patellar TS (OR range 1.5-2.01), and those with PF symptoms without MRI PFOA had significantly greater odds of wrist TS (OR 1.66). Males with PF symptoms without MRI PFOA had significantly lower pressure PPT at the patella compared with no PFOA and those with MRI PFOA only (no symptoms). There were no significant differences at the wrist for males, or the patella or wrist for females. Persons with PFOA symptoms, regardless of MRI PFOA status, are more likely to demonstrate depressive symptoms, catastrophizing, and TS. Males with PFOA symptoms without MRI PFOA demonstrate local hyperalgesia.

knee

magnetic resonance imaging

pain

osteoarthritis

Details

Title: Subtitle: Psychological and Pain Sensitization Characteristics Are Associated With Patellofemoral Osteoarthritis Symptoms: The Multicenter Osteoarthritis Study
Creators: Natalie J Collins - N. Collins, PT, PhD, B. Vicenzino, PT, PhD, School of Health and Rehabilitation Sciences, The University of Queensland, Brisbane, Australia; n.collins1@uq.edu.au
Tuhina Neogi - T. Neogi, MD, PhD, A. Guermazi, MD, PhD, School of Medicine, Boston University, Boston Massachusetts, USA
Bill Vicenzino - N. Collins, PT, PhD, B. Vicenzino, PT, PhD, School of Health and Rehabilitation Sciences, The University of Queensland, Brisbane, Australia
Ali Guermazi - T. Neogi, MD, PhD, A. Guermazi, MD, PhD, School of Medicine, Boston University, Boston Massachusetts, USA
Frank W Roemer - F.W. Roemer, MD, Department of Radiology, University of Erlangen-Nuremberg, Erlangen, Germany
Cora E Lewis - C.E. Lewis, MD, MSPH, Division of Preventive Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA
James C Torner - J.C. Torner, PhD, Department of Epidemiology, The University of Iowa, Iowa City, Iowa, USA
Michael C Nevitt - M.C. Nevitt, MPH, PhD, Department of Epidemiology and Biostatistics, University of California San Francisco, California, USA
Joshua J Stefanik - J.J. Stefanik, PT, PhD, Department of Physical Therapy, Movement and Rehabilitation Sciences, Northeastern University, Boston, Massachusetts, USA
Resource Type: Journal article
Publication Details: Journal of rheumatology, Vol.47(11), pp.1696-1703
DOI: 10.3899/jrheum.190981
PMID: 32115429
PMCID: PMC8005266
NLM abbreviation: J Rheumatol
ISSN: 0315-162X
eISSN: 1499-2752
Grant note: U01 AG018947 / NIA NIH HHS U01 AG018832 / NIA NIH HHS P30 AR072571 / NIAMS NIH HHS K24 AR070892 / NIAMS NIH HHS U01 AG019069 / NIA NIH HHS P60 AR047785 / NIAMS NIH HHS U54 GM104941 / NIGMS NIH HHS R01 AR062506 / NIAMS NIH HHS U01 AG018820 / NIA NIH HHS K23 AR070913 / NIAMS NIH HHS
Language: English
Date published: 11/01/2020
Academic Unit: Epidemiology; Surgery; Injury Prevention Research Center; Neurosurgery
Record Identifier: 9984214788802771

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