Journal article
Psychometric Study of the Social Responsiveness Scale in Phelan–McDermid Syndrome
Autism research, Vol.13(8), pp.1383-1396
08/2020
DOI: 10.1002/aur.2299
PMCID: PMC8103889
PMID: 32406614
Abstract
The Social Responsiveness Scale-2 (SRS-2) is a quantitative measure used to characterize symptoms of autism spectrum disorder (ASD). However, research suggests that SRS-2 scores are significantly influenced by language ability and intellectual disability (ID). Efforts to refine the SRS-2 by Sturm, Kuhfeld, Kasari, and Mccracken [Journal of Child Psychology and Psychiatry, 58(9), 1053–1061] yielded a shortened form, yet its psychometric properties in populations with severe ID remain unknown. This study aims to examine the psychometric properties of the SRS-2 in Phelan–McDermid syndrome (PMS), a genetic condition associated with ASD and ID, thereby guiding score interpretation in this population and future development of targeted scales. Analyses, including Item Response Theory (IRT), were conducted on a sample of individuals with PMS (n = 91) recruited at six sites nationally. Psychometric properties evaluated include measures of reliability (internal consistency, test–retest reliability) and validity (structural, construct, content). While both SRS-2 forms are reliable, the shortened SRS-2 shows superior validity to the full SRS-2 for measuring ASD symptoms in PMS. On IRT analysis, the shortened SRS-2 shows excellent discrimination and precisely evaluates respondents across a wide range of ASD symptomatology but interpretation is limited by uncertain content validity and small sample size. The shortened SRS-2 shows some promise for use in PMS, but future refinements and additions are needed to develop items that are tailored to identify ASD in children with severe ID and specifically PMS. Lay Summary: This study determined that a shortened form of the Social Responsiveness Scale, Second Edition (SRS-2) shows both promise and limitations for the characterization of autism symptomatology in individuals with Phelan–McDermid syndrome (PMS), a population characterized by intellectual disability (ID). Caution should be used when interpreting SRS-2 scores in individuals with ID and future research should modify existing items and develop new items to improve the SRS-2's ability to accurately characterize autism symptomatology in PMS. Autism Res 2020, 13: 1383–1396. © 2020 International Society for Autism Research, Wiley Periodicals, Inc.
Details
- Title: Subtitle
- Psychometric Study of the Social Responsiveness Scale in Phelan–McDermid Syndrome
- Creators
- Kellie Gergoudis - Icahn School of Medicine at Mount SinaiAlan Weinberg - Icahn School of Medicine at Mount SinaiJonathan Templin - University of KansasCristan Farmer - National Institutes of HealthAlison Durkin - Icahn School of Medicine at Mount SinaiJordana Weissman - Icahn School of Medicine at Mount SinaiPaige Siper - Icahn School of Medicine at Mount SinaiJennifer Foss-Feig - Icahn School of Medicine at Mount SinaiMaria Pilar Trelles - Seaver Autism Center, Department of PsychiatryIcahn School of Medicine at Mount Sinai New York New York USAJonathan A. Bernstein - Stanford UniversityJoseph D. Buxbaum - Icahn School of Medicine at Mount SinaiElizabeth Berry-Kravis - Rush University Medical CenterCraig M. Powell - University of Alabama at BirminghamMustafa Sahin - Boston Children's HospitalLatha Soorya - Rush University Medical CenterAudrey Thurm - National Institutes of HealthAlexander Kolevzon - Icahn School of Medicine at Mount SinaiDevelopmental Synaptopathies Consortium
- Resource Type
- Journal article
- Publication Details
- Autism research, Vol.13(8), pp.1383-1396
- DOI
- 10.1002/aur.2299
- PMID
- 32406614
- PMCID
- PMC8103889
- NLM abbreviation
- Autism Res
- ISSN
- 1939-3792
- eISSN
- 1939-3806
- Grant note
- DOI: 10.13039/100009633, name: Eunice Kennedy Shriver National Institute of Child Health and Human Development, award: U54NS092090; DOI: 10.13039/100006108, name: National Center for Advancing Translational Sciences; DOI: 10.13039/100000025, name: National Institute of Mental Health, award: ZICMH002961; DOI: 10.13039/100000065, name: National Institute of Neurological Disorders and Stroke, award: U54NS092090
- Language
- English
- Date published
- 08/2020
- Academic Unit
- Psychological and Quantitative Foundations
- Record Identifier
- 9984371105802771
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