Journal article
Psychometric utility of the international HIV dementia scale and Montreal Cognitive Assessment in HIV-associated asymptomatic neurocognitive impairment
Journal of neurovirology, Vol.27(4), pp.568-578
08/01/2021
DOI: 10.1007/s13365-021-00991-z
PMID: 34185242
Abstract
There is a growing need for brief screening measures for HIV Associated Neurocognitive Disorders (HAND). We compared two commonly used measures (the Montreal Cognitive Assessment [MoCA] and the International HIV Dementia Scale [IHDS]) in their ability to identify asymptomatic HAND (i.e., asymptomatic neurocognitive impairment [ANI]). Participants included 74 Thai PLWH: 38 met Frascati criteria for ANI and 36 were cognitively normal (CN). Participants completed Thai language versions of the MoCA (MoCA-T) and IHDS, and a validated neurocognitive battery. We examined between-group differences for MoCA-T and IHDS total scores, and scale subcomponents. We also conducted receiver operating characteristic (ROC) analyses to determine the ability of the MoCA-T and IHDS to discriminate between CN and ANI groups, and compared their area under the curve (AUC) values. Results revealed lower MoCA-T total score, as well as the Visuospatial/Executive and Delayed Recall subtask scores, in the ANI relative to CN group. Groups did not differ on the IHDS. For ROC analyses, the MoCA-T, but not the IHDS, significantly differentiated the ANI from CN group, and there was a significant difference in AUC values between the MoCA-T (AUC = .71) and IHDS (AUC = .56). Sensitivity and specificity statistics were poor for both screening measures. These data indicate while the MoCA-T functions better than the IHDS in detecting Thai PLWH with ANI, the mildest form of HAND, neither cognitive screener, showed strong utility. Our findings reflect the limited efficacy of common screening measures in detecting subtler cognitive deficits among Thai PLWH, and highlight the need for better screening tools.
Details
- Title: Subtitle
- Psychometric utility of the international HIV dementia scale and Montreal Cognitive Assessment in HIV-associated asymptomatic neurocognitive impairment
- Creators
- Stephen L. Aita - Dartmouth CollegeQuanhathai Kaewpoowat - Chiang Mai UniversitySaowaluck Yasri - Chiang Mai UniversityAmaraporn Rerkasem - Chiang Mai UniversityKittipan Rerkasem - Chiang Mai UniversityJanejit Choovuthayakorn - Chiang Mai UniversitySomsanguan Ausayakhun - Chiang Mai UniversityKevin Robertson - University of North Carolina at Chapel HillRobert M. Roth - Dartmouth CollegeNathaniel M. Robbins - Dartmouth College
- Resource Type
- Journal article
- Publication Details
- Journal of neurovirology, Vol.27(4), pp.568-578
- Publisher
- Springer Nature
- DOI
- 10.1007/s13365-021-00991-z
- PMID
- 34185242
- ISSN
- 1355-0284
- eISSN
- 1538-2443
- Number of pages
- 11
- Grant note
- Research Institute for Health Sciences, Chiang Mai University Dartmouth-Hitchcock Department of Neurology Alexander Reeves Endowment Fund UL1TR001086 / Dartmouth Clinical and Translational Science Institute from the National Center for Advancing Translational Sciences (NCATS) of the National Institutes of Health (NIH); United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Advancing Translational Sciences (NCATS) Department of State Fulbright Research Program
- Language
- English
- Date published
- 08/01/2021
- Academic Unit
- Internal Medicine
- Record Identifier
- 9984359571702771
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