Journal article
Psychosis and vulnerability to ECT-induced seizures
Psychiatry research, Vol.62(2), pp.191-201
05/17/1996
DOI: 10.1016/0165-1781(96)02775-8
PMID: 8771616
Abstract
Medical records of patients with major depressive disorders who had received electroconvulsive therapy (ECT) for the first time were studied to test the hypothesis that psychotic patients are more vulnerable to seizure than non-psychotic patients. This hypothesis was based on studies suggesting a putative purinergic deficiency in psychosis. Results showed that the duration of ECT-induced seizure as a measure of seizure vulnerability was significantly longer in psychotic than in nonpsychotic depressive patients. The association applied for the first ECT as well as for the course of eight ECTs. These findings were sill present when covariates such as age, electrical energy applied, dosage of methohexital and succinylcholine, and psychotropic medications such as neuroleptics, benzodiazepines, and tricyclics were included in the statistical analysis. The results are discussed in the context of the role of neurotransmitters such as glutamine, γ-aminobutyric acid, adenosine, and dopamine on seizure vulnerability and psychosis.
Details
- Title: Subtitle
- Psychosis and vulnerability to ECT-induced seizures
- Creators
- Rafiq Waziri - University of IowaSankar Baruah - University of IowaStephan Arndt - University of IowaKaren Baumert - University of IowaJon Cooney - University of IowaLaura Christensen - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Psychiatry research, Vol.62(2), pp.191-201
- DOI
- 10.1016/0165-1781(96)02775-8
- PMID
- 8771616
- NLM abbreviation
- Psychiatry Res
- ISSN
- 0165-1781
- eISSN
- 1872-7123
- Number of pages
- 11
- Language
- English
- Date published
- 05/17/1996
- Academic Unit
- Psychiatry; Biostatistics; Nursing; Injury Prevention Research Center
- Record Identifier
- 9985132077302771
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