Psychosocial disability and work role function compared across the long-term course of bipolar I, bipolar II and unipolar major depressive disorders

Lewis L Judd; Pamela J Schettler; David A Solomon; Jack D Maser; William Coryell; Jean Endicott; Hagop S Akiskal

doi:10.1016/j.jad.2007.06.014

Back

Psychosocial disability and work role function compared across the long-term course of bipolar I, bipolar II and unipolar major depressive disorders

Journal article

Peer reviewed

Psychosocial disability and work role function compared across the long-term course of bipolar I, bipolar II and unipolar major depressive disorders

Lewis L Judd, Pamela J Schettler, David A Solomon, Jack D Maser, William Coryell, Jean Endicott and Hagop S Akiskal

Journal of affective disorders, Vol.108(1), pp.49-58

2008

DOI: 10.1016/j.jad.2007.06.014

PMID: 18006071

View Online

Abstract

The research literature on psychosocial disability and work in mood disorders has either focused on relatively short-term course, or did not consider direct comparisons of these domains across all three of the affective subtypes of bipolar I (BP-I), bipolar II (BP-II), and unipolar major depressive disorders (UP-MDD). Mean composite measures of psychosocial impairment and months at specific levels of overall and work impairment were compared for 158 BP-I, 133 BP-II, and 358 UP-MDD patients based on semi-structured interviews conducted during 15 years of follow-up in the NIMH Collaborative Depression Study (CDS). These are contrasted with a single month of psychosocial impairment ratings for a sample of 1787 subjects with no current psychiatric disorder. Patients with mood disorders experienced some degree of disability during the majority of long-term follow-up (54 to 59% of months), including 19 to 23% of months with moderate and 7 to 9% of months with severe overall impairment. Severe disability occurred a substantial percentage of time only in the specific area of work role function. BP-I patients were completely unable to carry out work role functions during 30% of assessed months, which was significantly more than for UP-MDD and BP-II patients (21% and 20%, respectively). These findings have public health, economic, and clinical importance, and underscore the need to reduce the chronicity and impairment associated with these three prevalent affective disorder subtypes. Interventional research is just beginning to address these challenges.

Unipolar

Bipolar I

Work role function

Long-term disability

Bipolar II

LIFE-RIFT

Details

Title: Subtitle: Psychosocial disability and work role function compared across the long-term course of bipolar I, bipolar II and unipolar major depressive disorders
Creators: Lewis L Judd - Department of Psychiatry, University of California at San Diego, La Jolla, CA, USA
Pamela J Schettler - Department of Psychiatry, University of California at San Diego, La Jolla, CA, USA
David A Solomon - Department of Psychiatry, Brown University, Providence, RI, USA
Jack D Maser - Department of Psychiatry, University of California at San Diego, La Jolla, CA, USA
William Coryell - Department of Psychiatry, University of Iowa, Iowa City, IA, USA
Jean Endicott - Department of Research, Assessment and Training, Columbia University, New York, NY, USA
Hagop S Akiskal - Department of Psychiatry, University of California at San Diego, La Jolla, CA, USA
Resource Type: Journal article
Publication Details: Journal of affective disorders, Vol.108(1), pp.49-58
DOI: 10.1016/j.jad.2007.06.014
PMID: 18006071
NLM abbreviation: J Affect Disord
ISSN: 0165-0327
eISSN: 1573-2517
Publisher: Elsevier B.V
Language: English
Date published: 2008
Academic Unit: Psychiatry
Record Identifier: 9984003422402771

Metrics

20 Record Views

215 Times Cited - Web of Science

See more details