Psychosocial impairment and recurrence of major depression

David A Solomon; Andrew C Leon; Jean Endicott; Timothy I Mueller; William Coryell; M Tracie Shea; Martin B Keller

doi:10.1016/j.comppsych.2004.07.002

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Psychosocial impairment and recurrence of major depression

Journal article

Peer reviewed

Psychosocial impairment and recurrence of major depression

David A Solomon, Andrew C Leon, Jean Endicott, Timothy I Mueller, William Coryell, M Tracie Shea and Martin B Keller

Comprehensive psychiatry, Vol.45(6), pp.423-430

11/2004

DOI: 10.1016/j.comppsych.2004.07.002

PMID: 15526252

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https://doaj.org/article/ba25f37e4e794b8491d034b8f27c81ceView

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Abstract

Major depressive disorder is often marked by multiple recurrences. Unfortunately, it is difficult to predict specifically which patients will suffer a recurrence. This study examined whether psychosocial impairment is a risk factor for recurrence. A total of 290 subjects with unipolar major depressive disorder according to Research Diagnostic Criteria (RDC) were prospectively followed for up to 15 years as part of the Collaborative Depression Study (CDS), a multicenter longitudinal observational study of the mood disorders. Follow-up data on course of illness and psychosocial functioning were collected with the Longitudinal Interval Follow-up Evaluation (LIFE). The association of psychosocial impairment with recurrence of major depression was examined with mixed-effects logistic regression. The mean (SD) score for psychosocial functioning during recovery from an episode of major depression was 9.0 (2.7), with a possible range of 4 (no impairment) to 20 (severe impairment). For euthymic subjects who recovered from an episode of major depression, elevated psychosocial impairment was significantly associated with subsequent recurrence of major depression, with an odds ratio of 1.12 (95% confidence interval [CI], 1.06 to 1.19). The odds ratio of 1.12 indicates that for each 1-point increase in the functional impairment score, the risk of recurrence increases by about 12%. In patients who have recovered from an episode of major depression, the presence of psychosocial impairment may help identify who is at increased risk of recurrence.

Demography

Comorbidity

Psychology

Severity of Illness Index

Recurrence

Prospective Studies

Follow-Up Studies

Humans

Male

Depressive Disorder, Major - epidemiology

Depressive Disorder, Major - psychology

Social Behavior

Adolescent

Adult

Female

Psychological Tests

Depressive Disorder, Major - diagnosis

Personality Disorders - diagnosis

Child

Personality Disorders - epidemiology

Details

Title: Subtitle: Psychosocial impairment and recurrence of major depression
Creators: David A Solomon - Department of Psychiatry and Human Behavior, Brown University, Providence, RI, USA
Andrew C Leon
Jean Endicott
Timothy I Mueller
William Coryell
M Tracie Shea
Martin B Keller
Resource Type: Journal article
Publication Details: Comprehensive psychiatry, Vol.45(6), pp.423-430
DOI: 10.1016/j.comppsych.2004.07.002
PMID: 15526252
NLM abbreviation: Compr Psychiatry
ISSN: 0010-440X
eISSN: 1532-8384
Publisher: United States
Grant note: R01 MH025478 / NIMH NIH HHS
Language: English
Date published: 11/2004
Academic Unit: Psychiatry
Record Identifier: 9984004195502771

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