Journal article
Pulmonary Artery Aneurysm in Behcet Disease: Medical, Endovascular or Surgical Intervention
Curēus (Palo Alto, CA), Vol.15(11), e49368
11/24/2023
DOI: 10.7759/cureus.49368
PMCID: PMC10749288
PMID: 38146562
Abstract
Behçet's disease is a chronic inflammatory condition that predominantly affects the body's blood vessels, exhibiting various clinical manifestations and complications. The exact cause remains unclear, but genetic predisposition, immune responses, and vascular activation are believed to contribute to its development. This disease is more prevalent in certain geographic regions and primarily affects young adults, particularly males. Pulmonary aneurysm, a complication of Behçet's disease, is the leading cause of mortality in Behcet disease. In this review, we summarize the complications of Behcet disease with a focus on pulmonary artery aneurysms. We discussed the medical, endovascular, and surgical management of pulmonary aneurysms in Behcet disease and the indications and outcomes of the different treatment options. Corticosteroids and cyclophosphamide remain the preferred first-line therapy. However, clinical improvement with infliximab or adalimumab, tumor necrosis factor-alpha (TNFα) blocking agents, have been reported after treatment failure with recommended first-line agents. In patients who fail medical therapy or those with life-threatening hemoptysis, endovascular or surgical intervention is the next option. Endovascular interventions include pulmonary artery embolization with coils or acrylic glue and using plugs, occluders, or stents. Endovascular interventions usually have fewer adverse effects than surgery. Although the risk of surgical procedures is high in pulmonary artery aneurysms, it could be a life-saving procedure in patients with life-threatening hemoptysis. Surgical options, including pulmonary artery ligation, aneurysmorrhaphy, segmentectomy, lobectomy, or pneumonectomy are available. However, the results of surgical therapy for Behçet aneurysms are often disappointing.
Details
- Title: Subtitle
- Pulmonary Artery Aneurysm in Behcet Disease: Medical, Endovascular or Surgical Intervention
- Creators
- Isha Samreen - Internal Medicine, Hemet Global Medical Center, Hemet, USA Infectious Disease, Hemet Global Medical Center, Hemet, USAPuja Darji - Internal Medicine, Hemet Global Medical Center, Hemet, USA Infectious Disease, Hemet Global Medical Center, Hemet, USASatchel Genobaga - Internal Medicine, Hemet Global Medical Center, Hemet, USA Infectious Disease, Hemet Global Medical Center, Hemet, USASaivishnu Doosetty - Internal Medicine, Hemet Global Medical Center, Hemet, USA Infectious Disease, Hemet Global Medical Center, Hemet, USATamanna Mohta - Internal Medicine, Hemet Global Medical Center, Hemet, USA Infectious Disease, Hemet Global Medical Center, Hemet, USAGargi Maity - Internal Medicine, Hemet Global Medical Center, Hemet, USA Infectious Disease, Hemet Global Medical Center, Hemet, USAChong Vue - Internal Medicine, Hemet Global Medical Center, Hemet, USA Infectious Disease, Hemet Global Medical Center, Hemet, USASriharsha Nakka - Internal Medicine, Hemet Global Medical Center, Hemet, USA Infectious Disease, Hemet Global Medical Center, Hemet, USAChukwuemeka Umeh - Internal Medicine, Hemet Global Medical Center, Hemet, USA Infectious Disease, Hemet Global Medical Center, Hemet, USA
- Resource Type
- Journal article
- Publication Details
- Curēus (Palo Alto, CA), Vol.15(11), e49368
- DOI
- 10.7759/cureus.49368
- PMID
- 38146562
- PMCID
- PMC10749288
- NLM abbreviation
- Cureus
- ISSN
- 2168-8184
- eISSN
- 2168-8184
- Publisher
- Cureus
- Language
- English
- Date published
- 11/24/2023
- Academic Unit
- Internal Medicine
- Record Identifier
- 9984845466502771
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