Journal article
Pulmonary Biomechanics in COPD: Imaging Techniques and Clinical Applications
Journal of biomechanical engineering, Vol.147(10), 100801
10/01/2025
DOI: 10.1115/1.4069594
PMCID: PMC12617610
PMID: 40888816
Abstract
The respiratory system depends on complex biomechanical processes to enable gas exchange. The mechanical properties of the lung parenchyma, airways, vasculature, and surrounding structures play an essential role in overall ventilation efficacy. These complex biomechanical processes however are significantly altered in chronic obstructive pulmonary disease (COPD) due to emphysematous destruction of lung parenchyma, chronic airway inflammation, and small airway obstruction. Recent advancements computed tomography (CT) and magnetic resonance imaging (MRI) acquisition techniques, combined with sophisticated image post-processing algorithms and deep neural network integration, have enabled comprehensive quantitative assessment of lung structure, tissue deformation, and lung function at the tissue level. These methods have led to better phenotyping, therapeutic strategies and refined our understanding of pathological processes that compromise pulmonary function in COPD. In this review, we discuss recent developments in imaging and image processing methods for studying pulmonary biomechanics with specific focus on clinical applications for chronic obstructive pulmonary disease (COPD) including the assessment of regional ventilation, planning of endobronchial valve treatment, prediction of disease onset and progression, sizing of lungs for transplantation, and guiding mechanical ventilation. These advanced image-based biomechanical measurements when combined with clinical expertise play a critical role in disease management and personalized therapeutic interventions for patients with COPD.
Details
- Title: Subtitle
- Pulmonary Biomechanics in COPD: Imaging Techniques and Clinical Applications
- Creators
- Stephanie Marie Aguilera - University of Alabama at BirminghamMuhammad F. A. Chaudhary - University of Alabama at BirminghamSarah E Gerard - University of IowaJoseph M Reinhardt - University of IowaSandeep Bodduluri - University of Alabama at Birmingham
- Resource Type
- Journal article
- Publication Details
- Journal of biomechanical engineering, Vol.147(10), 100801
- DOI
- 10.1115/1.4069594
- PMID
- 40888816
- PMCID
- PMC12617610
- NLM abbreviation
- J Biomech Eng
- ISSN
- 0148-0731
- eISSN
- 1528-8951
- Publisher
- ASME
- Number of pages
- 41
- Grant note
- NHLBI: K01HL163249
NHLBI K01HL163249 (SB) (Funder ID: 10.13039/100000050).
- Language
- English
- Electronic publication date
- 09/01/2025
- Date published
- 10/01/2025
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiology
- Record Identifier
- 9984958625302771
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