Journal article
Pulmonary Function is Associated with Distal Aortic Calcium, not Proximal Aortic Distensibility. MESA Lung Study
Chronic obstructive pulmonary disease, Vol.8(2), pp.71-78
04/2011
DOI: 10.3109/15412555.2011.558543
PMCID: PMC3629728
PMID: 21495835
Abstract
Forced expiratory volume in one second strongly predicts mortality from cardiovascular disease. FEV
1
has been associated with aortic stiffness a strong independent predictor of cardiovascular mortality. However, the anatomical site and possible mechanisms linking aortic stiffness and lung function are unknown. We therefore examined if FEV
1
and CT percent emphysema were associated with calcification of the abdominal aorta or reduced distensibility of the proximal thoracic aorta.
The Multi-Ethnic Study of Atherosclerosis (MESA) measured aortic calcification on cardiac and abdominal CT scans and proximal aortic distensibility using magnetic resonance among participants aged 45–84 years without clinical cardiovascular disease. Spirometry was measured following ATS/ERS guidelines and percent emphysema was measured in the lung fields of cardiac CT scans. Multivariate analyses adjusted for age, sex, race/ethnicity and cardiovascular risk factors.
Of 1,917 participants with aortic distensibility measures, 13% were current and 38% were former smokers. Eighteen percent had airflow limitation without asthma. FEV
1
was associated with the extent of distal aortic calcification (0.76; 95%CI 0.60–0.97, p=0.02) but not proximal aortic calcification or proximal aortic distensibility (−0.04 mmHg
−1
; 95%CI −0.16–0.09 mmHg
−1
, p=0.60). Percent emphysema was associated with neither measure.
FEV
1
was associated with severity of distal aortic calcification where it was present independently of smoking and other cardiovascular risk factors but not with distensibility or calcification of the proximal aorta.
Details
- Title: Subtitle
- Pulmonary Function is Associated with Distal Aortic Calcium, not Proximal Aortic Distensibility. MESA Lung Study
- Creators
- David McAllister - MRC/ELEGI Colt Laboratories, University of Edinburgh, Edinburgh, UKWilliam MacNee - MRC/ELEGI Colt Laboratories, University of Edinburgh, Edinburgh, UKDaniel Duprez - Department of Medicine, University of Minnesota, Minnesota, USAEric A Hoffman - Department of Radiology, University of Iowa, Iowa City, Iowa, USAJens Vogel-Claussen - National Institutes of Health, Bethesda, Maryland, USAMichael H Criqui - Department of Family and Preventive Medicine, University of California San Diego School of Medicine, La Jolla, California, USAMatthew Budoff - Division of Cardiology, Harbor-UCLA Medical Center, Torrance, California, USARui Jiang - Department Medicine, College of Physicians and Surgeons, Columbia University, New York, New York, USADavid A Bluemke - National Institutes of Health, Bethesda, Maryland, USAR Graham Barr - Department Medicine, College of Physicians and Surgeons, Columbia University, New York, New York, USA
- Resource Type
- Journal article
- Publication Details
- Chronic obstructive pulmonary disease, Vol.8(2), pp.71-78
- DOI
- 10.3109/15412555.2011.558543
- PMID
- 21495835
- PMCID
- PMC3629728
- NLM abbreviation
- COPD
- ISSN
- 1541-2555
- eISSN
- 1541-2563
- Grant note
- R01 HL077612 || HL / National Heart, Lung, and Blood Institute : NHLBI R01 HL093081 || HL / National Heart, Lung, and Blood Institute : NHLBI
- Language
- English
- Date published
- 04/2011
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiology; Internal Medicine
- Record Identifier
- 9984051593402771
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