Journal article
Pulmonary Functional Imaging: Part 1-State-of-the-Art Technical and Physiologic Underpinnings
Radiology, Vol.299(3), pp.203711-523
04/06/2021
DOI: 10.1148/radiol.2021203711
PMCID: PMC8165947
PMID: 33825513
Abstract
Over the past few decades, pulmonary imaging technologies have advanced from chest radiography and nuclear medicine methods to high-spatial-resolution or low-dose chest CT and MRI. It is currently possible to identify and measure pulmonary pathologic changes before these are obvious even to patients or depicted on conventional morphologic images. Here, key technological advances are described, including multiparametric CT image processing methods, inhaled hyperpolarized and fluorinated gas MRI, and four-dimensional free-breathing CT and MRI methods to measure regional ventilation, perfusion, gas exchange, and biomechanics. The basic anatomic and physiologic underpinnings of these pulmonary functional imaging techniques are explained. In addition, advances in image analysis and computational and artificial intelligence (machine learning) methods pertinent to functional lung imaging are discussed. The clinical applications of pulmonary functional imaging, including both the opportunities and challenges for clinical translation and deployment, will be discussed in part 2 of this review. Given the technical advances in these sophisticated imaging methods and the wealth of information they can provide, it is anticipated that pulmonary functional imaging will be increasingly used in the care of patients with lung disease. © RSNA, 2021
Details
- Title: Subtitle
- Pulmonary Functional Imaging: Part 1-State-of-the-Art Technical and Physiologic Underpinnings
- Creators
- Yoshiharu Ohno - Fujita Health UniversityJoon Beom Seo - Ulsan University HospitalGrace Parraga - Western UniversityKyung Soo Lee - Sungkyunkwan UniversityWarren B Gefter - University of PennsylvaniaSean B Fain - University of Wisconsin–MadisonMark L Schiebler - University of Wisconsin–MadisonHiroto Hatabu - Harvard University
- Resource Type
- Journal article
- Publication Details
- Radiology, Vol.299(3), pp.203711-523
- DOI
- 10.1148/radiol.2021203711
- PMID
- 33825513
- PMCID
- PMC8165947
- ISSN
- 0033-8419
- eISSN
- 1527-1315
- Grant note
- name: National Instutitues of Health, award: R01CA203636, 5U01CA209414-03, R01HL135142; DOI: 10.13039/100000050, name: National Heart, Lung, and Blood Institute, award: 1R01HL130974, 2R01HL111024-06; DOI: 10.13039/100000050, name: National Heart, Lung, and Blood Institute, award: 1U01 HL102225-01, R01 HL091762, P01 HL07083; name: Pulmonary Imaging Center, Office of the Vice Chancellor for Research and Graduate Education at the University of Wisconsin–Madison with funding from the Wisconsin Alumni Research Foundation, award: S10 OD016394, R01 EB021314, U01 HL146002, UG1 HL139118, R01 HL126771; DOI: 10.13039/501100000024, name: Canadian Institutes of Health Research, award: PJT 148624, HEV 440431
- Language
- English
- Date published
- 04/06/2021
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiology; Electrical and Computer Engineering; Health and Human Physiology
- Record Identifier
- 9984274958202771
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