Journal article
Pulmonary He-3 magnetic resonance imaging of childhood asthma
Journal of allergy and clinical immunology, Vol.131(2), p.369
02/01/2013
DOI: 10.1016/j.jaci.2012.10.032
PMCID: PMC3563846
PMID: 23246019
Abstract
Background: Magnetic resonance imaging (MRI) with He-3 does not require ionizing radiation and has been shown to detect regional abnormalities in lung ventilation and structure in adults with asthma, but the method has not been extended to children with asthma. Measurements of regional lung ventilation and microstructure in subjects with childhood asthma could advance our understanding of disease mechanisms.
Objective: We sought to determine whether He-3 MRI in children can identify abnormalities related to the diagnosis of asthma or prior history of respiratory illness.
Methods: Forty-four children aged 9 to 10 years were recruited from a birth cohort at increased risk of asthma and allergic diseases. For each subject, a time-resolved 3-dimensional image series and a 3-dimensional diffusion-weighted image were acquired in separate breathing maneuvers. The numbers and sizes of ventilation defects were scored, and regional maps and statistics of average He-3 diffusion lengths were calculated.
Results: Children with mild-to-moderate asthma had lower average root-mean-square diffusion length ((X-rms) over bar) values (P = .004), increased regional SD of diffusion length values (P = .03), and higher defect scores (P = .03) than those without asthma. Children with histories of wheezing illness with rhinovirus infection before the third birthday had lower (X-rms) over bar values (P = .01) and higher defect scores (P = .05).
Conclusion: MRI with He-3 detected more and larger regions of ventilation defect and a greater degree of restricted gas diffusion in children with asthma compared with those seen in children without asthma. These measures are consistent with regional obstruction and smaller and more regionally variable dimensions of the peripheral airways and alveolar spaces. (J Allergy Clin Immunol 2013;131:369-76.)
Details
- Title: Subtitle
- Pulmonary He-3 magnetic resonance imaging of childhood asthma
- Creators
- Robert V. Cadman - University of Wisconsin–MadisonRobert F. Lemanske - University of Wisconsin–MadisonMichael D. Evans - University of Wisconsin–MadisonDaniel J. Jackson - University of Wisconsin–MadisonJames E. Gern - University of Wisconsin–MadisonRonald L. Sorkness - University of Wisconsin–MadisonSean B. Fain - University of Wisconsin–Madison
- Resource Type
- Journal article
- Publication Details
- Journal of allergy and clinical immunology, Vol.131(2), p.369
- DOI
- 10.1016/j.jaci.2012.10.032
- PMID
- 23246019
- PMCID
- PMC3563846
- NLM abbreviation
- J Allergy Clin Immunol
- ISSN
- 0091-6749
- eISSN
- 1097-6825
- Publisher
- Elsevier
- Number of pages
- 13
- Grant note
- NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA Allegheny General Hospital; General Electric UL1TR000427 / NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Advancing Translational Sciences (NCATS) American Academy of Allergy, Asthma Immunology Harvard Pilgrim Health GE Healthcare; General Electric California Society of Allergy NYC Allergy Society Michigan Public Health Institute California Chapter 4 of the American Academy of Pediatrics Pennsylvania Allergy and Asthma Association T32CA009206 / NATIONAL CANCER INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI) UL1RR025011 / NATIONAL CENTER FOR RESEARCH RESOURCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Research Resources (NCRR) NIH/NHLBI; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI) West Allegheny Health Systems AstraZeneca P01 HL070831; 5T32 CA009206-31; 1UL1RR025011 / National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA Merck; Merck & Company Hartwell Foundation Colorado Allergy Society National Heart, Lung, and Blood Institute (NHLBI); United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI) American Academy of Pediatrics American College of Chest Physicians; General Electric National Institutes of Health (NIH); United States Department of Health & Human Services; National Institutes of Health (NIH) - USA Pharmaxis GlaxoSmithKline P01HL070831 / NATIONAL HEART, LUNG, AND BLOOD INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI) World Allergy Organization
- Language
- English
- Date published
- 02/01/2013
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiology; Electrical and Computer Engineering; Health, Sport, and Human Physiology
- Record Identifier
- 9984274952602771
Metrics
18 Record Views