Pulmonary Hyperinflation and Left Ventricular Mass: The Multi-Ethnic Study of Atherosclerosis COPD Study

Benjamin M Smith; Steven M Kawut; David A Bluemke; Robert C Basner; Antoinette S Gomes; Eric Hoffman; Ravi Kalhan; João A.C Lima; Chia-Ying Liu; Erin D Michos; Martin R Prince; LeRoy Rabbani; Daniel Rabinowitz; Daichi Shimbo; Steven Shea; R. Graham Barr

doi:10.1161/CIRCULATIONAHA.113.001653

Back

Pulmonary Hyperinflation and Left Ventricular Mass: The Multi-Ethnic Study of Atherosclerosis COPD Study

Journal article

Open access

Peer reviewed

Pulmonary Hyperinflation and Left Ventricular Mass: The Multi-Ethnic Study of Atherosclerosis COPD Study

Benjamin M Smith, Steven M Kawut, David A Bluemke, Robert C Basner, Antoinette S Gomes, Eric Hoffman, Ravi Kalhan, João A.C Lima, Chia-Ying Liu, Erin D Michos, …

Circulation (New York, N.Y.), Vol.127(14), pp.1503-1511

04/09/2013

DOI: 10.1161/CIRCULATIONAHA.113.001653

PMID: 23493320

Files and links (1)

url

https://doi.org/10.1161/CIRCULATIONAHA.113.001653View

Published (Version of record) Open Access

Abstract

Background— Left ventricular (LV) mass is an important predictor of heart failure and cardiovascular mortality, yet determinants of LV mass are incompletely understood. Pulmonary hyperinflation in chronic obstructive pulmonary disease (COPD) may contribute to changes in intrathoracic pressure that increase LV wall stress. We therefore hypothesized that residual lung volume in COPD would be associated with greater LV mass. Methods and Results— The Multi-Ethnic Study of Atherosclerosis (MESA) COPD Study recruited smokers 50 to 79 years of age who were free of clinical cardiovascular disease. LV mass was measured by cardiac magnetic resonance. Pulmonary function testing was performed according to guidelines. Regression models were used to adjust for age, sex, body size, blood pressure, and other cardiac risk factors. Among 119 MESA COPD Study participants, the mean age was 69±6 years, 55% were male, and 65% had COPD, mostly of mild or moderate severity. Mean LV mass was 128±34 g. Residual lung volume was independently associated with greater LV mass (7.2 g per 1-SD increase in residual volume; 95% confidence interval, 2.2–12; P=0.004) and was similar in magnitude to that of systolic blood pressure (7.6 g per 1-SD increase in systolic blood pressure; 95% confidence interval, 4.3–11; P<0.001). Similar results were observed for the ratio of LV mass to end-diastolic volume (P=0.02) and with hyperinflation measured as residual volume to total lung capacity ratio (P=0.009). Conclusions— Pulmonary hyperinflation, as measured by residual lung volume or residual lung volume to total lung capacity ratio, is associated with greater LV mass.

Details

Title: Subtitle: Pulmonary Hyperinflation and Left Ventricular Mass: The Multi-Ethnic Study of Atherosclerosis COPD Study
Creators: Benjamin M Smith - From the Departments of Medicine (B.M.S., R.C.B., L.R., D.S., S.S., R.G.B.) and Radiology (M.R.P.), College of Physicians and Surgeons, Columbia University, New York, NY; Department of Medicine, McGill University Health Center, Montreal, QC, Canada (B.M.S.); Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia (S.M.K.); Radiology and Imaging Sciences, National Institutes of Health, Bethesda, MD (D.A.B.); David Geffen UCLA School of Medicine, Los Angeles, CA
Steven M Kawut - From the Departments of Medicine (B.M.S., R.C.B., L.R., D.S., S.S., R.G.B.) and Radiology (M.R.P.), College of Physicians and Surgeons, Columbia University, New York, NY; Department of Medicine, McGill University Health Center, Montreal, QC, Canada (B.M.S.); Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia (S.M.K.); Radiology and Imaging Sciences, National Institutes of Health, Bethesda, MD (D.A.B.); David Geffen UCLA School of Medicine, Los Angeles, CA
David A Bluemke - From the Departments of Medicine (B.M.S., R.C.B., L.R., D.S., S.S., R.G.B.) and Radiology (M.R.P.), College of Physicians and Surgeons, Columbia University, New York, NY; Department of Medicine, McGill University Health Center, Montreal, QC, Canada (B.M.S.); Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia (S.M.K.); Radiology and Imaging Sciences, National Institutes of Health, Bethesda, MD (D.A.B.); David Geffen UCLA School of Medicine, Los Angeles, CA
Robert C Basner - From the Departments of Medicine (B.M.S., R.C.B., L.R., D.S., S.S., R.G.B.) and Radiology (M.R.P.), College of Physicians and Surgeons, Columbia University, New York, NY; Department of Medicine, McGill University Health Center, Montreal, QC, Canada (B.M.S.); Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia (S.M.K.); Radiology and Imaging Sciences, National Institutes of Health, Bethesda, MD (D.A.B.); David Geffen UCLA School of Medicine, Los Angeles, CA
Antoinette S Gomes - From the Departments of Medicine (B.M.S., R.C.B., L.R., D.S., S.S., R.G.B.) and Radiology (M.R.P.), College of Physicians and Surgeons, Columbia University, New York, NY; Department of Medicine, McGill University Health Center, Montreal, QC, Canada (B.M.S.); Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia (S.M.K.); Radiology and Imaging Sciences, National Institutes of Health, Bethesda, MD (D.A.B.); David Geffen UCLA School of Medicine, Los Angeles, CA
Eric Hoffman - From the Departments of Medicine (B.M.S., R.C.B., L.R., D.S., S.S., R.G.B.) and Radiology (M.R.P.), College of Physicians and Surgeons, Columbia University, New York, NY; Department of Medicine, McGill University Health Center, Montreal, QC, Canada (B.M.S.); Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia (S.M.K.); Radiology and Imaging Sciences, National Institutes of Health, Bethesda, MD (D.A.B.); David Geffen UCLA School of Medicine, Los Angeles, CA
Ravi Kalhan - From the Departments of Medicine (B.M.S., R.C.B., L.R., D.S., S.S., R.G.B.) and Radiology (M.R.P.), College of Physicians and Surgeons, Columbia University, New York, NY; Department of Medicine, McGill University Health Center, Montreal, QC, Canada (B.M.S.); Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia (S.M.K.); Radiology and Imaging Sciences, National Institutes of Health, Bethesda, MD (D.A.B.); David Geffen UCLA School of Medicine, Los Angeles, CA
João A.C Lima - From the Departments of Medicine (B.M.S., R.C.B., L.R., D.S., S.S., R.G.B.) and Radiology (M.R.P.), College of Physicians and Surgeons, Columbia University, New York, NY; Department of Medicine, McGill University Health Center, Montreal, QC, Canada (B.M.S.); Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia (S.M.K.); Radiology and Imaging Sciences, National Institutes of Health, Bethesda, MD (D.A.B.); David Geffen UCLA School of Medicine, Los Angeles, CA
Chia-Ying Liu - From the Departments of Medicine (B.M.S., R.C.B., L.R., D.S., S.S., R.G.B.) and Radiology (M.R.P.), College of Physicians and Surgeons, Columbia University, New York, NY; Department of Medicine, McGill University Health Center, Montreal, QC, Canada (B.M.S.); Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia (S.M.K.); Radiology and Imaging Sciences, National Institutes of Health, Bethesda, MD (D.A.B.); David Geffen UCLA School of Medicine, Los Angeles, CA
Erin D Michos - From the Departments of Medicine (B.M.S., R.C.B., L.R., D.S., S.S., R.G.B.) and Radiology (M.R.P.), College of Physicians and Surgeons, Columbia University, New York, NY; Department of Medicine, McGill University Health Center, Montreal, QC, Canada (B.M.S.); Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia (S.M.K.); Radiology and Imaging Sciences, National Institutes of Health, Bethesda, MD (D.A.B.); David Geffen UCLA School of Medicine, Los Angeles, CA
Martin R Prince - From the Departments of Medicine (B.M.S., R.C.B., L.R., D.S., S.S., R.G.B.) and Radiology (M.R.P.), College of Physicians and Surgeons, Columbia University, New York, NY; Department of Medicine, McGill University Health Center, Montreal, QC, Canada (B.M.S.); Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia (S.M.K.); Radiology and Imaging Sciences, National Institutes of Health, Bethesda, MD (D.A.B.); David Geffen UCLA School of Medicine, Los Angeles, CA
LeRoy Rabbani - From the Departments of Medicine (B.M.S., R.C.B., L.R., D.S., S.S., R.G.B.) and Radiology (M.R.P.), College of Physicians and Surgeons, Columbia University, New York, NY; Department of Medicine, McGill University Health Center, Montreal, QC, Canada (B.M.S.); Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia (S.M.K.); Radiology and Imaging Sciences, National Institutes of Health, Bethesda, MD (D.A.B.); David Geffen UCLA School of Medicine, Los Angeles, CA
Daniel Rabinowitz - From the Departments of Medicine (B.M.S., R.C.B., L.R., D.S., S.S., R.G.B.) and Radiology (M.R.P.), College of Physicians and Surgeons, Columbia University, New York, NY; Department of Medicine, McGill University Health Center, Montreal, QC, Canada (B.M.S.); Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia (S.M.K.); Radiology and Imaging Sciences, National Institutes of Health, Bethesda, MD (D.A.B.); David Geffen UCLA School of Medicine, Los Angeles, CA
Daichi Shimbo - From the Departments of Medicine (B.M.S., R.C.B., L.R., D.S., S.S., R.G.B.) and Radiology (M.R.P.), College of Physicians and Surgeons, Columbia University, New York, NY; Department of Medicine, McGill University Health Center, Montreal, QC, Canada (B.M.S.); Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia (S.M.K.); Radiology and Imaging Sciences, National Institutes of Health, Bethesda, MD (D.A.B.); David Geffen UCLA School of Medicine, Los Angeles, CA
Steven Shea - From the Departments of Medicine (B.M.S., R.C.B., L.R., D.S., S.S., R.G.B.) and Radiology (M.R.P.), College of Physicians and Surgeons, Columbia University, New York, NY; Department of Medicine, McGill University Health Center, Montreal, QC, Canada (B.M.S.); Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia (S.M.K.); Radiology and Imaging Sciences, National Institutes of Health, Bethesda, MD (D.A.B.); David Geffen UCLA School of Medicine, Los Angeles, CA
R. Graham Barr - From the Departments of Medicine (B.M.S., R.C.B., L.R., D.S., S.S., R.G.B.) and Radiology (M.R.P.), College of Physicians and Surgeons, Columbia University, New York, NY; Department of Medicine, McGill University Health Center, Montreal, QC, Canada (B.M.S.); Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia (S.M.K.); Radiology and Imaging Sciences, National Institutes of Health, Bethesda, MD (D.A.B.); David Geffen UCLA School of Medicine, Los Angeles, CA
Resource Type: Journal article
Publication Details: Circulation (New York, N.Y.), Vol.127(14), pp.1503-1511
DOI: 10.1161/CIRCULATIONAHA.113.001653
PMID: 23493320
NLM abbreviation: Circulation
ISSN: 0009-7322
eISSN: 1524-4539
Publisher: Lippincott Williams & Wilkins
Language: English
Date published: 04/09/2013
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Radiology; Internal Medicine
Record Identifier: 9984051739902771

Metrics

63 Record Views

71 Times Cited - Web of Science