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Pulmonary Hypertension Associated with Bronchopulmonary Dysplasia: A Review
Journal article   Open access   Peer reviewed

Pulmonary Hypertension Associated with Bronchopulmonary Dysplasia: A Review

Nidhy Varghese and Danielle Rios
Pediatric allergy, immunology, and pulmonology, Vol.32(4), pp.140-148
12/01/2019
DOI: 10.1089/ped.2018.0984
PMCID: PMC6918524
PMID: 31871821
url
https://doi.org/10.1089/ped.2018.0984View
Published (Version of record) Open Access

Abstract

Early pulmonary vascular disease (PVD) and established pulmonary hypertension (PH) are common associations of bronchopulmonary dysplasia (BPD). Diagnosis of PH is often made by echocardiography because of technical and logistic difficulties with the neonatal population. Optimization of respiratory support is the focus of treatment, however, medical therapies are being used with increased frequency. The prognosis for PH associated with BPD (PH-BPD) is tied to the child's respiratory status. PH is associated with increased risk of death in this population, so active screening and treatment is recommended to minimize morbidity and mortality. In this review, we discuss the pathophysiology of PH in infants with BPD, evaluate the current understanding of screening, diagnosis, and follow-up evaluation; describe comorbid conditions; and provide a framework for targeted physiology-based management strategies.
 Allergy Immunology Life Sciences & Biomedicine Pediatrics Respiratory System Science & Technology

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