Journal article
Pulmonary Hypertension and Computed Tomography Measurement of Small Pulmonary Vessels in Severe Emphysema
American journal of respiratory and critical care medicine, Vol.181(3), pp.218-225
02/01/2010
DOI: 10.1164/rccm.200908-1189OC
PMCID: PMC2817812
PMID: 19875683
Abstract
Rationale
: Vascular alteration of small pulmonary vessels is one of the characteristic features of pulmonary hypertension in chronic obstructive pulmonary disease. The
in vivo
relationship between pulmonary hypertension and morphological alteration of the small pulmonary vessels has not been assessed in patients with severe emphysema.
Objectives
: We evaluated the correlation of total cross-sectional area of small pulmonary vessels (CSA) assessed on computed tomography (CT) scans with the degree of pulmonary hypertension estimated by right heart catheterization.
Methods
: In 79 patients with severe emphysema enrolled in the National Emphysema Treatment Trial (NETT), we measured CSA less than 5 mm
2
(CSA
<5
) and 5 to 10 mm
2
(CSA
5−10
), and calculated the percentage of total CSA for the lung area (%CSA
<5
and %CSA
5–10
, respectively). The correlations of %CSA
<5
and %CSA
5–10
with pulmonary arterial mean pressure (
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) obtained by right heart catheterization were evaluated. Multiple linear regression analysis using
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as the dependent outcome was also performed.
Measurements and Main Results
: The %CSA
<5
had a significant negative correlation with
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(
r
= −0.512,
P
< 0.0001), whereas the correlation between %CSA
5–10
and
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did not reach statistical significance (
r
= −0.196,
P
= 0.083). Multiple linear regression analysis showed that %CSA
<5
and diffusing capacity of carbon monoxide (D
l
CO
) % predicted were independent predictors of
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(
r
2
= 0.541): %CSA
<5
(
P
< 0.0001), and D
l
CO
% predicted (
P
= 0.022).
Conclusions
: The %CSA
<5
measured on CT images is significantly correlated to
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in severe emphysema and can estimate the degree of pulmonary hypertension.
Details
- Title: Subtitle
- Pulmonary Hypertension and Computed Tomography Measurement of Small Pulmonary Vessels in Severe Emphysema
- Creators
- Shin Matsuoka - Department of RadiologyGeorge R Washko - Department of RadiologyTsuneo Yamashiro - Department of RadiologyRaul San Jose Estepar - Department of RadiologyAlejandro Diaz - Department of RadiologyEdwin K Silverman - Department of RadiologyEric Hoffman - Department of RadiologyHenry E Fessler - Department of RadiologyGerard J Criner - Department of RadiologyNathaniel Marchetti - Department of RadiologySteven M Scharf - Department of RadiologyFernando J Martinez - Department of RadiologyJohn J Reilly - Department of RadiologyHiroto Hatabu - Department of Radiology
- Resource Type
- Journal article
- Publication Details
- American journal of respiratory and critical care medicine, Vol.181(3), pp.218-225
- DOI
- 10.1164/rccm.200908-1189OC
- PMID
- 19875683
- PMCID
- PMC2817812
- NLM abbreviation
- Am J Respir Crit Care Med
- ISSN
- 1073-449X
- eISSN
- 1535-4970
- Publisher
- American Thoracic Society
- Language
- English
- Date published
- 02/01/2010
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiology; Internal Medicine
- Record Identifier
- 9984051871902771
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