Journal article
Pulmonary MRI of neonates in the intensive care unit using 3D ultrashort echo time and a small footprint MRI system
Journal of magnetic resonance imaging, Vol.45(2), pp.463-471
02/2017
DOI: 10.1002/jmri.25394
PMCID: PMC5222704
PMID: 27458992
Abstract
To determine the feasibility of pulmonary magnetic resonance imaging (MRI) of neonatal lung structures enabled by combining two novel technologies: first, a 3D radial ultrashort echo time (UTE) pulse sequence capable of high spatial resolution full-chest imaging in nonsedated quiet-breathing neonates; and second, a unique, small-footprint 1.5T MRI scanner design adapted for neonatal imaging and installed within the neonatal intensive care unit (NICU).
Ten patients underwent MRI within the NICU, in accordance with an approved Institutional Review Board protocol. Five had clinical diagnoses of bronchopulmonary dysplasia (BPD), and five had putatively normal lung function. Pulmonary imaging was performed at 1.5T using 3D radial UTE and standard 3D fast gradient recalled echo (FGRE). Diagnostic quality, presence of motion artifacts, and apparent severity of lung pathology were evaluated by two radiologists. Quantitative metrics were additionally used to evaluate lung parenchymal signal.
UTE images showed significantly higher signal in lung parenchyma (P < 0.0001) and fewer apparent motion artifacts compared to FGRE (P = 0.046). Pulmonary pathology was more severe in patients diagnosed with BPD relative to controls (P = 0.001). Infants diagnosed with BPD also had significantly higher signal in lung parenchyma, measured using UTE, relative to controls (P = 0.002).
These results demonstrate the technical feasibility of pulmonary MRI in free-breathing, nonsedated infants in the NICU at high, isotropic resolutions approaching that achievable with computed tomography (CT). There is potential for pulmonary MRI to play a role in improving how clinicians understand and manage care of neonatal and pediatric pulmonary diseases. J. Magn. Reson. Imaging 2016.
2 J. Magn. Reson. Imaging 2017;45:463-471.
Details
- Title: Subtitle
- Pulmonary MRI of neonates in the intensive care unit using 3D ultrashort echo time and a small footprint MRI system
- Creators
- Andrew D Hahn - University of Wisconsin–MadisonNara S Higano - Cincinnati Children's Hospital Medical CenterLaura L Walkup - Boston Children's HospitalRobert P Thomen - Boston Children's HospitalXuefeng Cao - Boston Children's HospitalStephanie L Merhar - Cincinnati Children's Hospital Medical CenterJean A Tkach - Cincinnati Children's Hospital Medical CenterJason C Woods - Boston Children's HospitalSean B Fain - University of Wisconsin–Madison
- Resource Type
- Journal article
- Publication Details
- Journal of magnetic resonance imaging, Vol.45(2), pp.463-471
- DOI
- 10.1002/jmri.25394
- PMID
- 27458992
- PMCID
- PMC5222704
- NLM abbreviation
- J Magn Reson Imaging
- ISSN
- 1053-1807
- eISSN
- 1522-2586
- Grant note
- T32 HL007752 / NHLBI NIH HHS R01 HL126771 / NHLBI NIH HHS T32 CA009206 / NCI NIH HHS P50 HL056387 / NHLBI NIH HHS P01 HL070831 / NHLBI NIH HHS S10 OD016394 / NIH HHS M01 RR008084 / NCRR NIH HHS UL1 TR001425 / NCATS NIH HHS
- Language
- English
- Date published
- 02/2017
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiology; Electrical and Computer Engineering; Health, Sport, and Human Physiology
- Record Identifier
- 9984274952402771
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