Pulmonary artery stiffness in chronic obstructive pulmonary disease (COPD) and emphysema: The Multi-Ethnic Study of Atherosclerosis (MESA) COPD Study

Chia-Ying Liu; Megha Parikh; David A Bluemke; Pallavi Balte; James Carr; Stephen Dashnaw; Hooman D Poor; Antoinette S Gomes; Eric A Hoffman; Steven M Kawut; Joao A C Lima; David A McAllister; Martin A Prince; Jens Vogel-Claussen; R Graham Barr

doi:10.1002/jmri.25753

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Pulmonary artery stiffness in chronic obstructive pulmonary disease (COPD) and emphysema: The Multi-Ethnic Study of Atherosclerosis (MESA) COPD Study

Journal article

Peer reviewed

Pulmonary artery stiffness in chronic obstructive pulmonary disease (COPD) and emphysema: The Multi-Ethnic Study of Atherosclerosis (MESA) COPD Study

Chia-Ying Liu, Megha Parikh, David A Bluemke, Pallavi Balte, James Carr, Stephen Dashnaw, Hooman D Poor, Antoinette S Gomes, Eric A Hoffman, Steven M Kawut, …

Journal of magnetic resonance imaging, Vol.47(1), pp.262-271

01/2018

DOI: 10.1002/jmri.25753

PMCID: PMC5681449

PMID: 28488348

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https://eprints.gla.ac.uk/view/journal_volume/Journal_of_Magnetic_Resonance_Imaging.html>,View

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Abstract

Chronic obstructive pulmonary disease (COPD) and particularly emphysema are characterized by stiffness of the aorta, due in part to accelerated elastin degradation in the lungs and aorta. Stiffness of the pulmonary arteries (PAs) may also be increased in COPD and emphysema, but data are lacking. We assessed PA stiffness using MRI in patients with COPD and related these measurements to COPD severity and percent emphysema. The Multi-Ethnic Study of Atherosclerosis (MESA) COPD Study recruited 290 participants, age 50-79 years with 10 or more packyears and free of clinical cardiovascular disease. COPD severity were defined on postbronchodilator spirometry by ATS/ERS criteria. Percent emphysema was defined as the percentage of regions of the lung < -950 Hounsfield units on full-lung computed tomography (CT). PA stain was defined by the percent change in cross-sectional PA area between systole and diastole on MRI. Blood flow across the tricuspid and mitral valves was assessed by phase-contrast MRI for determination of the ventricular diastolic dysfunction (E/A ratio). PA strain was reduced in COPD compared with controls (P = 0.002) and was inversely correlated with COPD severity (P = 0.004). PA strain was inversely associated to percent emphysema (P = 0.01). PA strain was also markedly correlated with right ventricular diastolic dysfunction measured by E/A ratios in the fully adjusted mix models (P = 0.02). PA strain is reduced in COPD, related in part to percent emphysema on CT scan, which may have implications for pulmonary small vessel flow and right ventricular function. 2 Technical Efficacy: Stage 1 J. Magn. Reson. Imaging 2018;47:262-271.

Emphysema - diagnostic imaging

Spirometry

Cross-Sectional Studies

Humans

Middle Aged

Risk Factors

Male

Tomography, X-Ray Computed

Lung - diagnostic imaging

Pulmonary Artery - diagnostic imaging

Pulmonary Emphysema - diagnostic imaging

Heart - diagnostic imaging

Gases

Atherosclerosis - diagnostic imaging

Ethnic Groups

Sensitivity and Specificity

Female

Pulmonary Disease, Chronic Obstructive - diagnostic imaging

Aged

Vascular Stiffness

Observer Variation

Plethysmography

Cohort Studies

Details

Title: Subtitle: Pulmonary artery stiffness in chronic obstructive pulmonary disease (COPD) and emphysema: The Multi-Ethnic Study of Atherosclerosis (MESA) COPD Study
Creators: Chia-Ying Liu - Radiology and Imaging Sciences, National Institutes of Health, Bethesda, Maryland, USA
Megha Parikh - Department of Medicine, College of Physicians and Surgeons, Columbia University Medical Center, New York, New York, USA
David A Bluemke - Radiology and Imaging Sciences, National Institutes of Health, Bethesda, Maryland, USA
Pallavi Balte - Department of Radiology, Johns Hopkins Hospital, Baltimore, Maryland, USA
James Carr - Department of Radiology, Northwestern University, Chicago, Illinois, USA
Stephen Dashnaw - Department of Radiology, College of Physicians and Surgeons, Columbia University Medical Center, New York, New York, USA
Hooman D Poor - Division of Pulmonary, Critical Care and Sleep Medicine, Mount Sinai-National Jewish Health Respiratory Institute, New York, New York, USA
Antoinette S Gomes - Department of Medicine, University of California, Los Angeles, Los Angeles, California, USA
Eric A Hoffman - Department of Radiology, University of Iowa, Iowa City, Iowa, USA
Steven M Kawut - Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
Joao A C Lima - Department of Radiology, Johns Hopkins Hospital, Baltimore, Maryland, USA
David A McAllister - Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom
Martin A Prince - Department of Radiology, Weill Cornell Medical College, New York, New York, USA
Jens Vogel-Claussen - Hannover Medical School, Hannover, Germany
R Graham Barr - Department of Epidemiology, Mailman School of Public Health, Columbia University Medical Center, New York, New York, USA
Resource Type: Journal article
Publication Details: Journal of magnetic resonance imaging, Vol.47(1), pp.262-271
DOI: 10.1002/jmri.25753
PMID: 28488348
PMCID: PMC5681449
NLM abbreviation: J Magn Reson Imaging
ISSN: 1053-1807
eISSN: 1522-2586
Publisher: United States
Grant note: P30 ES005605 / NIEHS NIH HHS N01HC95169 / NHLBI NIH HHS UL1 RR024156 / NCRR NIH HHS P30 ES009089 / NIEHS NIH HHS R01 HL077612 / NHLBI NIH HHS R01 HL093081 / NHLBI NIH HHS K24 HL103844 / NHLBI NIH HHS R01 HL075476 / NHLBI NIH HHS R01 HL112986 / NHLBI NIH HHS P30 DK054759 / NIDDK NIH HHS
Language: English
Date published: 01/2018
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Radiology; Internal Medicine
Record Identifier: 9984051568502771

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