Journal article
Pulmonary comorbidities in psoriasis are associated with a high risk of respiratory failure
Journal of international medical research, Vol.51(6), p.3000605231182881
06/01/2023
DOI: 10.1177/03000605231182881
PMID: 37340719
Abstract
Objectives
To identify respiratory comorbidities associated with a high risk of developing respiratory failure in subjects with psoriasis.
Methods
This was a cross-sectional analysis of data from subjects enrolled in the UK Biobank cohort. All diagnoses were self-reported. The risk of each respiratory comorbidity was compared by logistic regression models adjusting for age, sex, weight, diabetes mellitus, and smoking history; the risk of comorbid respiratory failure for each pulmonary comorbidity was also compared.
Results
Of the 472,782 Caucasian subjects in the database, 3,285 self-reported a diagnosis of psoriasis. More men and smokers reported psoriasis and were older, had higher weight and body mass index, and lower pulmonary function than non-psoriatic subjects. Those with psoriasis were at significantly higher risk for multiple pulmonary comorbidities compared to those without psoriasis. Furthermore, those with psoriasis had a higher risk for respiratory failure accompanied by asthma and airflow limitation than non-psoriatic subjects.
Conclusions
Subjects with psoriasis and pulmonary comorbidities, such as asthma and airflow limitation, are at increased risk for respiratory failure. Common immunopathological links implicating a ‘skin-lung axis’ may underlie psoriasis and pulmonary comorbidities.
Details
- Title: Subtitle
- Pulmonary comorbidities in psoriasis are associated with a high risk of respiratory failure
- Creators
- Kazuya Tanimura - University of PittsburghSeyed Mehdi Nouraie - University of PittsburghDivay Chandra - University of PittsburghToru Nyunoya - University of Pittsburgh
- Resource Type
- Journal article
- Publication Details
- Journal of international medical research, Vol.51(6), p.3000605231182881
- DOI
- 10.1177/03000605231182881
- PMID
- 37340719
- ISSN
- 0300-0605
- eISSN
- 1473-2300
- Publisher
- SAGE Publications
- Grant note
- 19TPA34830061 / American Heart Association (https://doi.org/10.13039/100000968) R01HL149719; R01HL153400 / National Heart, Lung, and Blood Institute (https://doi.org/10.13039/100000050) CX000105 / U.S. Department of Veterans Affairs (https://doi.org/10.13039/100000738)
- Language
- English
- Date published
- 06/01/2023
- Academic Unit
- Internal Medicine
- Record Identifier
- 9985214106902771
Metrics
1 Record Views