Pulmonary fibrosis 4 months after COVID-19 is associated with severity of illness and blood leucocyte telomere length

Claire F McGroder; David Zhang; Mohammad A Choudhury; Mary M Salvatore; Belinda M D'Souza; Eric A Hoffman; Ying Wei; Matthew R Baldwin; Christine Kim Garcia

doi:10.1136/thoraxjnl-2021-217031

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Pulmonary fibrosis 4 months after COVID-19 is associated with severity of illness and blood leucocyte telomere length

Journal article

Open access

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Pulmonary fibrosis 4 months after COVID-19 is associated with severity of illness and blood leucocyte telomere length

Claire F McGroder, David Zhang, Mohammad A Choudhury, Mary M Salvatore, Belinda M D'Souza, Eric A Hoffman, Ying Wei, Matthew R Baldwin and Christine Kim Garcia

Thorax, Vol.76(12), pp.1242-1245

04/29/2021

DOI: 10.1136/thoraxjnl-2021-217031

PMCID: PMC8103561

PMID: 33927016

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Abstract

The risk factors for development of fibrotic-like radiographic abnormalities after severe COVID-19 are incompletely described and the extent to which CT findings correlate with symptoms and physical function after hospitalisation remains unclear. At 4 months after hospitalisation, fibrotic-like patterns were more common in those who underwent mechanical ventilation (72%) than in those who did not (20%). We demonstrate that severity of initial illness, duration of mechanical ventilation, lactate dehydrogenase on admission and leucocyte telomere length are independent risk factors for fibrotic-like radiographic abnormalities. These fibrotic-like changes correlate with lung function, cough and measures of frailty, but not with dyspnoea.

Details

Title: Subtitle: Pulmonary fibrosis 4 months after COVID-19 is associated with severity of illness and blood leucocyte telomere length
Creators: Claire F McGroder - Columbia University
David Zhang - Columbia University
Mohammad A Choudhury - Columbia University
Mary M Salvatore - Columbia University Medical Center
Belinda M D'Souza - Radiology, Columbia University Medical Center, New York, New York, USA
Eric A Hoffman - University of Iowa
Ying Wei - Columbia University Irving Medical Center
Matthew R Baldwin - Columbia University
Christine Kim Garcia - Columbia University
Resource Type: Journal article
Publication Details: Thorax, Vol.76(12), pp.1242-1245
DOI: 10.1136/thoraxjnl-2021-217031
PMID: 33927016
PMCID: PMC8103561
NLM abbreviation: Thorax
ISSN: 0040-6376
eISSN: 1468-3296
Grant note: DOI: 10.13039/100000005, name: Department of Defense, award: PR202907; name: NIH, award: R01HL093096, R01HL103676, T32HL105323, UL1TR001873
Language: English
Date published: 04/29/2021
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Radiology; Internal Medicine
Record Identifier: 9984318807302771

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