Pulmonary function and airway inflammation among dairy parlor workers after exposure to inhalable aerosols

Matthew W Nonnenmann; David Gimeno Ruiz de Porras; Jeffrey Levin; David Douphrate; Vijay Boggaram; Joshua Schaffer; Michael Gallagher; Madeleine Hornick; Stephen Reynolds

doi:10.1002/ajim.22680

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Pulmonary function and airway inflammation among dairy parlor workers after exposure to inhalable aerosols

Journal article

Peer reviewed

Pulmonary function and airway inflammation among dairy parlor workers after exposure to inhalable aerosols

Matthew W Nonnenmann, David Gimeno Ruiz de Porras, Jeffrey Levin, David Douphrate, Vijay Boggaram, Joshua Schaffer, Michael Gallagher, Madeleine Hornick and Stephen Reynolds

American journal of industrial medicine, Vol.60(3), pp.255-263

03/2017

DOI: 10.1002/ajim.22680

PMCID: PMC7082837

PMID: 28195657

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Abstract

Inhalation exposure to organic dust causes lung inflammation among agricultural workers. Due to changes in production and work organization, task-based inhalation exposure data, including novel lung inflammation biomarkers, will inform exposure recommendations for dairy farm workers. Linear regression was used to estimate the associations of airborne exposure to dust concentration, endotoxin, and muramic acid with pulmonary outcomes (i.e., FEV , exhaled nitric oxide). Logistic regression was used to estimate associations with self-reported pulmonary symptoms. Mean exposure concentration to inhalable dust, endotoxin, and muramic acid were 0.55 mg/m , 118 EU/m , and 3.6 mg/m , respectively. We found cross-shift differences for exhaled nitric oxide (P = 0.005) and self-reported pulmonary symptoms (P = 0.008) but no association of exposure with respiratory outcomes. Inhalation exposures during parlor tasks, which were lower than previously reported and were not associated with cross-shift measures of pulmonary health among dairy workers. Modern milking parlor designs may be contributing to lower inhalation exposure. Am. J. Ind. Med. 60:255-263, 2017. © 2017 Wiley Periodicals, Inc.

Adult

Aerosols - analysis

Aerosols - toxicity

Air Pollutants, Occupational - analysis

Air Pollutants, Occupational - toxicity

Cross-Sectional Studies

Dairying

Dust - analysis

Endotoxins - analysis

Endotoxins - toxicity

Female

Humans

Inhalation Exposure - adverse effects

Inhalation Exposure - analysis

Lung Diseases - etiology

Lung Diseases - physiopathology

Male

Muramic Acids - analysis

Muramic Acids - toxicity

Occupational Diseases - etiology

Occupational Diseases - physiopathology

Occupational Exposure - adverse effects

Occupational Exposure - analysis

Respiratory Function Tests

Details

Title: Subtitle: Pulmonary function and airway inflammation among dairy parlor workers after exposure to inhalable aerosols
Creators: Matthew W Nonnenmann - University of Iowa
David Gimeno Ruiz de Porras - The University of Texas Health Science Center at Houston
Jeffrey Levin - Department of Occupational Health Sciences, UT Health Northeast, Tyler, Texas
David Douphrate - The University of Texas Health Science Center at Houston
Vijay Boggaram - Department of Occupational Health Sciences, UT Health Northeast, Tyler, Texas
Joshua Schaffer - Department of Cellular and Molecular Biology, UT Health Northeast, Tyler, Texas
Michael Gallagher - Colorado State University
Madeleine Hornick - Liberty Mutual Insurance, Portland, Oregon
Stephen Reynolds - Department of Cellular and Molecular Biology, UT Health Northeast, Tyler, Texas
Resource Type: Journal article
Publication Details: American journal of industrial medicine, Vol.60(3), pp.255-263
DOI: 10.1002/ajim.22680
PMID: 28195657
PMCID: PMC7082837
NLM abbreviation: Am J Ind Med
ISSN: 0271-3586
eISSN: 1097-0274
Grant note: U54 OH007548 / NIOSH CDC HHS P30 ES005605 / NIEHS NIH HHS L30 RR033224 / NCRR NIH HHS
Language: English
Date published: 03/2017
Academic Unit: Occupational and Environmental Health; Internal Medicine
Record Identifier: 9984226818902771

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