Journal article
Pulmonary function responses to ozone in smokers with a limited smoking history
Toxicology and applied pharmacology, Vol.278(1), pp.85-90
07/01/2014
DOI: 10.1016/j.taap.2014.04.011
PMID: 24747805
Abstract
In non-smokers, ozone (O3) inhalation causes decreases in forced expiratory volume (FEV1) and dead space (VD) and increases the slope of the alveolar plateau (SN). We previously described a population of smokers with a limited smoking history that had enhanced responsiveness to brief O3 boluses and aimed to determine if responsiveness to continuous exposure was also enhanced. Thirty smokers (19M, 11F, 24±4years, 6±4 total years smoking,4±2packs/week) and 30 non-smokers (17M, 13F, 25±6years) exercised for 1h on a cycle ergometer while breathing 0.30ppm O3. Smokers and non-smokers were equally responsive in terms of FEV1 (−9.5±1.8% vs −8.7±1.9%). Smokers alone were responsive in terms of VD (−6.1±1.2%) and SN (9.1±3.4%). There was no difference in total delivered dose. Dead space ventilation (VD/VT) was not initially different between the two groups, but increased in the non-smokers (16.4±2.8%) during the exposure, suggesting that the inhaled dose may be distributed more peripherally in smokers. We also conclude that these cigarette smokers retain their airway responsiveness to O3 and, uniquely, experience changes in VD that lead to heterogeneity in airway morphometry and an increase in SN.
•We previously found lung function responses to O3 bolus exposure in smokers.•Here, we describe their responsiveness to continuous O3 exposure with exercise.•Spirometry and capnography were used to assess pulmonary function changes.•Enhanced bronchoconstriction in smokers increases parenchymal delivery of O3.
Details
- Title: Subtitle
- Pulmonary function responses to ozone in smokers with a limited smoking history
- Creators
- Melissa L Bates - University of Wisconsin–MadisonTimothy M Brenza - Pennsylvania State UniversityAbdellaziz Ben-Jebria - Pennsylvania State UniversityRebecca Bascom - Pennsylvania State UniversityMarlowe W Eldridge - University of Wisconsin School of Medicine and Public HealthJames S Ultman - Pennsylvania State University
- Resource Type
- Journal article
- Publication Details
- Toxicology and applied pharmacology, Vol.278(1), pp.85-90
- Publisher
- Elsevier Inc
- DOI
- 10.1016/j.taap.2014.04.011
- PMID
- 24747805
- ISSN
- 0041-008X
- eISSN
- 1096-0333
- Language
- English
- Date published
- 07/01/2014
- Academic Unit
- Stead Family Department of Pediatrics; Fraternal Order of Eagles Diabetes Research Center; Health and Human Physiology; Internal Medicine
- Record Identifier
- 9984259656002771
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