Pulmonary hyperinflation due to gas trapping and pulmonary artery size: The MESA COPD Study

Hooman D Poor; Steven M Kawut; Chia-Ying Liu; Benjamin M Smith; Eric A Hoffman; João A Lima; Bharath Ambale-Venkatesh; Erin D Michos; Martin R Prince; R Graham Barr

doi:10.1371/journal.pone.0176812

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Pulmonary hyperinflation due to gas trapping and pulmonary artery size: The MESA COPD Study

Journal article

Open access

Peer reviewed

Pulmonary hyperinflation due to gas trapping and pulmonary artery size: The MESA COPD Study

Hooman D Poor, Steven M Kawut, Chia-Ying Liu, Benjamin M Smith, Eric A Hoffman, João A Lima, Bharath Ambale-Venkatesh, Erin D Michos, Martin R Prince and R Graham Barr

PloS one, Vol.12(5), pp.e0176812-e0176812

2017

DOI: 10.1371/journal.pone.0176812

PMCID: PMC5413010

PMID: 28463971

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Abstract

Pulmonary hypertension is associated with increased morbidity and mortality in chronic obstructive pulmonary disease (COPD). Since pulmonary artery (PA) size increases in pulmonary hypertension, we measured PA cross-sectional area using magnetic resonance imaging (MRI) to test the hypothesis that pulmonary hyperinflation due to gas trapping is associated with PA cross-sectional area in COPD. The MESA COPD Study recruited participants with COPD and controls from two population-based cohort studies ages 50-79 years with 10 or more pack-years and free of clinical cardiovascular disease. Body plethysmography was performed according to standard criteria. Cardiac MRI was performed at functional residual capacity to measure the cross-sectional area of the main PA. Percent emphysema was defined as the percentage of lung voxels less than -950 Hounsfield units as assessed via x-ray computed tomography. Analyses were adjusted for age, gender, height, weight, race-ethnicity, the forced expiratory volume in one second, smoking status, pack-years, lung function, oxygen saturation, blood pressure, left ventricular ejection fraction and percent emphysema. Among 106 participants, mean residual volume was 1.98±0.71 L and the mean PA cross-sectional area was 7.23±1.72 cm2. A one standard deviation increase in residual volume was independently associated with an increase in main PA cross-sectional area of 0.55 cm2 (95% CI 0.18 to 0.92; p = 0.003). In contrast, there was no evidence for an association with percent emphysema or total lung capacity. Increased residual volume was associated with a larger PA in COPD, suggesting that gas trapping may contribute to pulmonary hypertension in COPD.

Magnetic Resonance Imaging

Aged

Cohort Studies

Cross-Sectional Studies

Female

Forced Expiratory Volume

Heart - diagnostic imaging

Humans

Hypertension, Pulmonary - diagnostic imaging

Hypertension, Pulmonary - physiopathology

Lung - diagnostic imaging

Lung - physiopathology

Male

Middle Aged

Organ Size

Plethysmography, Whole Body

Pulmonary Artery - diagnostic imaging

Pulmonary Disease, Chronic Obstructive - diagnostic imaging

Pulmonary Disease, Chronic Obstructive - physiopathology

Pulmonary Emphysema - diagnostic imaging

Pulmonary Emphysema - physiopathology

Residual Volume

Tomography, X-Ray Computed

Details

Title: Subtitle: Pulmonary hyperinflation due to gas trapping and pulmonary artery size: The MESA COPD Study
Creators: Hooman D Poor - Department of Medicine, Columbia University Medical Center, New York, New York, United States of America
Steven M Kawut - University of Pennsylvania
Chia-Ying Liu - Johns Hopkins University
Benjamin M Smith - McGill University
Eric A Hoffman - University of Iowa, Radiology
João A Lima - Johns Hopkins Medicine
Bharath Ambale-Venkatesh - Johns Hopkins Medicine
Erin D Michos - Johns Hopkins University
Martin R Prince - Columbia University
R Graham Barr - Columbia University Irving Medical Center
Resource Type: Journal article
Publication Details: PloS one, Vol.12(5), pp.e0176812-e0176812
DOI: 10.1371/journal.pone.0176812
PMID: 28463971
PMCID: PMC5413010
NLM abbreviation: PLoS One
ISSN: 1932-6203
eISSN: 1932-6203
Grant note: P30 ES005605 / NIEHS NIH HHS R01 HL093081 / NHLBI NIH HHS K24 HL103844 / NHLBI NIH HHS R01 HL112986 / NHLBI NIH HHS P30 DK054759 / NIDDK NIH HHS R01 HL077612 / NHLBI NIH HHS
Language: English
Date published: 2017
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Radiology; Internal Medicine
Record Identifier: 9984240438602771

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9 Times Cited - Web of Science