Journal article
Pulmonary immunity and immunopathology: lessons from respiratory syncytial virus
Expert review of vaccines, Vol.7(8), pp.1239-1255
10/2008
DOI: 10.1586/14760584.7.8.1239
PMCID: PMC2630464
PMID: 18844597
Abstract
Respiratory syncytial virus (RSV) is the leading cause of severe respiratory disease in infants and is an important source of morbidity and mortality in the elderly and immunocompromised. This review will discuss the humoral and cellular adaptive immune responses to RSV infection and how these responses are shaped in the immature immune system of the infant and the aged environment of the elderly. Furthermore, we will provide an overview of our current understanding of the role the various arms of the adaptive immune response play in mediating the delicate balance between the successful elimination of the virus from the host and the induction of immunopathology. Efficacious immunization against RSV remains a high priority within the field and we will highlight recent advances made in vaccine design.
Details
- Title: Subtitle
- Pulmonary immunity and immunopathology: lessons from respiratory syncytial virus
- Creators
- Matthew R Olson - Department of Microbiology, Interdisciplinary Graduate Program in Immunology, 51 Newton Road, 3-532 Bowen Science Building, University of Iowa, Iowa City, IA 52242, USA. matthew-r-olson@uiowa.eduSteven M Varga
- Resource Type
- Journal article
- Publication Details
- Expert review of vaccines, Vol.7(8), pp.1239-1255
- DOI
- 10.1586/14760584.7.8.1239
- PMID
- 18844597
- PMCID
- PMC2630464
- NLM abbreviation
- Expert Rev Vaccines
- ISSN
- 1476-0584
- eISSN
- 1744-8395
- Grant note
- R01 AI-063520 / NIAID NIH HHS R01 AI063520-02 / NIAID NIH HHS R01 AI063520 / NIAID NIH HHS
- Language
- English
- Date published
- 10/2008
- Academic Unit
- Graduate College Admin and Gen; Microbiology and Immunology; Pathology
- Record Identifier
- 9984083289002771
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