Pulmonary neuroendocrine cells sense succinate to stimulate myoepithelial cell contraction

Wenjie Yu; Thomas O Moninger; Michael V Rector; David A Stoltz; Michael J Welsh

doi:10.1016/j.devcel.2022.08.010

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Pulmonary neuroendocrine cells sense succinate to stimulate myoepithelial cell contraction

Journal article

Open access

Peer reviewed

Pulmonary neuroendocrine cells sense succinate to stimulate myoepithelial cell contraction

Wenjie Yu, Thomas O Moninger, Michael V Rector, David A Stoltz and Michael J Welsh

Developmental cell, Vol.57(18), pp.2221-2236.e5

09/08/2022

DOI: 10.1016/j.devcel.2022.08.010

PMCID: PMC9762774

PMID: 36108628

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Abstract

Pulmonary neuroendocrine cells (PNECs) are rare airway cells with potential sensory capacity linked to vagal neurons and immune cells. How PNECs sense and respond to external stimuli remains poorly understood. We discovered PNECs located within pig and human submucosal glands, a tissue that produces much of the mucus that defends the lung. These PNECs sense succinate, an inflammatory molecule in liquid lining the airway surface. The results indicate that succinate migrates down the submucosal gland duct to the acinus, where it triggers apical succinate receptors, causing PNECs to release ATP. The short-range ATP signal stimulates the contraction of myoepithelial cells wrapped tightly around the submucosal glands. Succinate-triggered gland contraction may complement the action of neurotransmitters that induce mucus release but not gland contraction to promote mucus ejection onto the airway surface. These findings identify a local circuit in which rare PNECs within submucosal glands sense an environmental cue to orchestrate the function of airway glands.

Details

Title: Subtitle: Pulmonary neuroendocrine cells sense succinate to stimulate myoepithelial cell contraction
Creators: Wenjie Yu - Roy J. and Lucille A. Carver College of Medicine
Thomas O Moninger
Michael V Rector
David A Stoltz
Michael J Welsh
Resource Type: Journal article
Publication Details: Developmental cell, Vol.57(18), pp.2221-2236.e5
DOI: 10.1016/j.devcel.2022.08.010
PMID: 36108628
PMCID: PMC9762774
NLM abbreviation: Dev Cell
ISSN: 1534-5807
eISSN: 1878-1551
Grant note: DOI: 10.13039/100000897, name: Cystic Fibrosis Foundation; DOI: 10.13039/100001024, name: Roy J. Carver Charitable Trust; DOI: 10.13039/100008893, name: University of Iowa; DOI: 10.13039/100012483, name: University of Georgia Research Foundation; DOI: 10.13039/100000002, name: National Institutes of Health, award: HL051670, HL091842; DOI: 10.13039/100000011, name: Howard Hughes Medical Institute
Language: English
Date published: 09/08/2022
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Neurology; Molecular Physiology and Biophysics; Pulmonary, Critical Care, and Occupational Medicine; Fraternal Order of Eagles Diabetes Research Center; Neurosurgery; Internal Medicine
Record Identifier: 9984297556602771

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