Pulmonary perfused blood volume with dual-energy CT as surrogate for pulmonary perfusion assessed with dynamic multidetector CT

Matthew K Fuld; Ahmed F Halaweish; Susan E Haynes; Abhay A Divekar; Junfeng Guo; Eric A Hoffman

doi:10.1148/radiol.12112789

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Pulmonary perfused blood volume with dual-energy CT as surrogate for pulmonary perfusion assessed with dynamic multidetector CT

Journal article

Open access

Peer reviewed

Pulmonary perfused blood volume with dual-energy CT as surrogate for pulmonary perfusion assessed with dynamic multidetector CT

Matthew K Fuld, Ahmed F Halaweish, Susan E Haynes, Abhay A Divekar, Junfeng Guo and Eric A Hoffman

Radiology, Vol.267(3), pp.747-756

06/2013

DOI: 10.1148/radiol.12112789

PMCID: PMC3662901

PMID: 23192773

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Abstract

To compare measurements of regional pulmonary perfused blood volume (PBV) and pulmonary blood flow (PBF) obtained with computed tomography (CT) in two pig models. The institutional animal care and use committee approved all animal studies. CT-derived PBF and PBV were determined in four anesthetized, mechanically ventilated, supine swine by using two methods for creating pulmonary parenchymal perfusion heterogeneity. Two animals were examined after sequentially moving a pulmonary arterial balloon catheter from a distal to a central location, and two others were examined over a range of static airway pressures, which varied the extents of regional PBF. Lung sections were divided into blocks and Pearson correlation coefficients calculated to compare matching regions between the two methods. CT-derived PBF, CT-derived PBV, and their associated coefficients of variation (CV) were closely correlated on a region-by-region basis in both the balloon occlusion (Pearson R = 0.91 and 0.73 for animals 1 and 2, respectively; Pearson R = 0.98 and 0.87 for comparison of normalized mean and CV for animals 1 and 2, respectively) and lung inflation studies (Pearson R = 0.94 and 0.74 for animals 3 and 4, respectively; Pearson R = 0.94 and 0.69 for normalized mean and CV for animals 3 and 4, respectively). When accounting for region-based effects, correlations remained highly significant at the P < .001 level. CT-derived PBV heterogeneity is a suitable surrogate for CT-derived PBF heterogeneity.

Animals

Iopamidol - administration & dosage

Swine

Contrast Media - administration & dosage

Multidetector Computed Tomography - methods

Blood Volume - physiology

Models, Animal

Lung - diagnostic imaging

Lung - blood supply

Blood Flow Velocity - physiology

Details

Title: Subtitle: Pulmonary perfused blood volume with dual-energy CT as surrogate for pulmonary perfusion assessed with dynamic multidetector CT
Creators: Matthew K Fuld - Department of Radiology, University of Iowa Carver College of Medicine, 200 Hawkins Dr, CC 701 GH, Iowa City, IA 52241, USA
Ahmed F Halaweish
Susan E Haynes
Abhay A Divekar
Junfeng Guo
Eric A Hoffman
Resource Type: Journal article
Publication Details: Radiology, Vol.267(3), pp.747-756
DOI: 10.1148/radiol.12112789
PMID: 23192773
PMCID: PMC3662901
NLM abbreviation: Radiology
ISSN: 0033-8419
eISSN: 1527-1315
Publisher: United States
Grant note: P30 ES005605 / NIEHS NIH HHS R01-HL-064368 / NHLBI NIH HHS R01 HL112986 / NHLBI NIH HHS R01 HL064368 / NHLBI NIH HHS
Language: English
Date published: 06/2013
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Radiology; Stead Family Department of Pediatrics; Internal Medicine
Record Identifier: 9984051755002771

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