Journal article
Pulmonary toxicity, hepatic, and extrahepatic metabolism of 2-methylnaphthalene in mice
Toxicology and applied pharmacology, Vol.61(2), pp.185-196
1981
DOI: 10.1016/0041-008X(81)90408-7
PMID: 7324064
Abstract
Male mice (
C57BL
6J
) were injected once ip with 0.1, 1, 100, 200, 400, 600, 800, or 1000 mg/kg of 2-methylnaphthalene dissolved in corn oil. After 24 hr, the animals were killed and the lungs, livers, and kidneys were prepared for light microscopy. In addition, some lungs were subjected to scanning and transmission electron microscopy. A dose of 200 mg/kg produced a bronchiolar necrosis which affected the nonciliated bronchiolar (Clara) cell; the parenchymal cells remained unaffected. At higher doses of 2-methylnaphthalene (800 mg/kg), in addition to the damaged Clara cell, severe damage to the upper respiratory tract was noted. No liver or kidney pathology was detected by light microscopy in animals treated with the highest dose. No cellular damage was noted in any organ at doses less than 200 mg/kg. Forty-eight hours after a dose of 200–1000 mg/kg of 2-methylnaphthalene, less pulmonary damage was detected by light microscopy. The metabolism of 2-methylnaphthalene was investigated in hepatic, pulmonary, and renal microsomes from
C57BL
6J
mice. Lung and liver microsomes produced three isomeric dihydrodiols of 2-methylnaphthalene as well as other monohydroxylated metabolites. Only trace amounts of these metabolites were produced by the kidney.
Details
- Title: Subtitle
- Pulmonary toxicity, hepatic, and extrahepatic metabolism of 2-methylnaphthalene in mice
- Creators
- Kathryn A Griffin - Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226 USACollin B Johnson - Department of Pathology, Waukesha Memorial Hospital, Waukesha, Wisconsin 53186 USARobert K Breger - Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226 USARonald B Franklin - Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226 USA
- Resource Type
- Journal article
- Publication Details
- Toxicology and applied pharmacology, Vol.61(2), pp.185-196
- Publisher
- Elsevier Inc
- DOI
- 10.1016/0041-008X(81)90408-7
- PMID
- 7324064
- ISSN
- 0041-008X
- eISSN
- 1096-0333
- Language
- English
- Date published
- 1981
- Academic Unit
- Cardiovascular Medicine; Neuroscience and Pharmacology; Internal Medicine
- Record Identifier
- 9984094629002771
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