Pulmonary vascular volume, impaired left ventricular filling and dyspnea: The MESA Lung Study

Carrie P Aaron; Eric A Hoffman; Joao A. C Lima; Steven M Kawut; Alain G Bertoni; Jens Vogel-Claussen; Mohammadali Habibi; Katja Hueper; David R Jacobs; Ravi Kalhan; Erin D Michos; Wendy S Post; Martin R Prince; Benjamin M Smith; Bharath Ambale-Venkatesh; Chia-Ying Liu; Filip Zemrak; Karol E Watson; Matthew Budoff; David A Bluemke; R. Graham Barr

doi:10.1371/journal.pone.0176180

Back

Pulmonary vascular volume, impaired left ventricular filling and dyspnea: The MESA Lung Study

Journal article

Open access

Peer reviewed

Pulmonary vascular volume, impaired left ventricular filling and dyspnea: The MESA Lung Study

Carrie P Aaron, Eric A Hoffman, Joao A. C Lima, Steven M Kawut, Alain G Bertoni, Jens Vogel-Claussen, Mohammadali Habibi, Katja Hueper, David R Jacobs, Ravi Kalhan, …

PloS one, Vol.12(4), pp.e0176180-e0176180

04/20/2017

DOI: 10.1371/journal.pone.0176180

PMCID: PMC5398710

PMID: 28426728

Files and links (1)

url

https://doi.org/10.1371/journal.pone.0176180View

Published (Version of record) Open Access

Abstract

Background Evaluation of impaired left ventricular (LV) filling has focused on intrinsic causes of LV dysfunction; however, pulmonary vascular changes may contribute to reduced LV filling and dyspnea. We hypothesized that lower total pulmonary vascular volume (TPVV) on computed tomography (CT) would be associated with dyspnea and decrements in LV end-diastolic volume, particularly among ever-smokers. Methods The Multi-Ethnic Study of Atherosclerosis recruited adults without clinical cardiovascular disease in 2000-02. In 2010-12, TPVV was ascertained as the volume of arteries and veins in the lungs detectable on non-contrast chest CT (vessels >= 1 mm diameter). Cardiac measures were assessed by magnetic resonance imaging (MRI). Dyspnea was selfreported. Results Of 2303 participants, 53% had ever smoked cigarettes. Among ever-smokers, a lower TPVV was associated with a lower LV end-diastolic volume (6.9 mL per SD TPVV), stroke volume, and cardiac output and with dyspnea (all P-values <0.001). Findings were similar among those without lung disease and those with 0-10 pack-years but were mostly non-significant among never-smokers. TPVV was associated smaller left atrial volume but not with LV ejection fraction or MRI measures of impaired LV relaxation. In a second sample of ever-smokers, a lower pulmonary microvascular blood volume on contrast-enhanced MRI was also associated with a lower LV end-diastolic volume (P-value = 0.008). Conclusion Reductions in pulmonary vascular volume were associated with lower LV filling and dyspnea among ever-smokers, including those without lung disease, suggesting that smoking-related pulmonary vascular changes may contribute to symptoms and impair cardiac filling and function without evidence of impaired LV relaxation.

Multidisciplinary Sciences

Science & Technology

Science & Technology - Other Topics

Details

Title: Subtitle: Pulmonary vascular volume, impaired left ventricular filling and dyspnea: The MESA Lung Study
Creators: Carrie P Aaron - Columbia Univ, Dept Med, Coll Phys & Surg, New York, NY USA
Eric A Hoffman - University of Iowa, Radiology
Joao A. C Lima - Johns Hopkins Univ, Sch Med, Dept Med, Baltimore, MD USA
Steven M Kawut - Univ Penn, Perelman Sch Med, Dept Med, Philadelphia, PA USA
Alain G Bertoni - Wake Forest Univ, Sch Med, Dept Med & Epidemiol & Prevent, Winston Salem, NC USA
Jens Vogel-Claussen - Hannover Med Sch, Dept Radiol, Hannover, Germany
Mohammadali Habibi - Johns Hopkins Medicine
Katja Hueper - Hannover Med Sch, Dept Radiol, Hannover, Germany
David R Jacobs - Univ Minnesota, Sch Publ Hlth, Div Epidemiol & Community Hlth, Minneapolis, MN USA
Ravi Kalhan - Northwestern Univ, Feinberg Sch Med, Asthma & COPD Program, Chicago, IL USA
Erin D Michos - Johns Hopkins Univ, Sch Med, Dept Med, Baltimore, MD USA
Wendy S Post - Johns Hopkins Univ, Sch Med, Dept Med, Baltimore, MD USA
Martin R Prince - Columbia Univ, Dept Radiol, Coll Phys & Surg, New York, NY USA
Benjamin M Smith - McGill University
Bharath Ambale-Venkatesh - Johns Hopkins Medicine
Chia-Ying Liu - Johns Hopkins University
Filip Zemrak - National Institutes of Health
Karol E Watson - Univ Calif Los Angeles, Dept Med, Los Angeles, CA USA
Matthew Budoff - Univ Calif Los Angeles, Dept Med, Los Angeles, CA USA
David A Bluemke - NIH, Ctr Clin, Radiol & Imaging Sci, Bethesda, MD USA
R. Graham Barr - Columbia University Irving Medical Center
Resource Type: Journal article
Publication Details: PloS one, Vol.12(4), pp.e0176180-e0176180
DOI: 10.1371/journal.pone.0176180
PMID: 28426728
PMCID: PMC5398710
NLM abbreviation: PLoS One
ISSN: 1932-6203
eISSN: 1932-6203
Publisher: PUBLIC LIBRARY SCIENCE
Number of pages: 19
Grant note: R831697 / US Environmental Protection Agency R01-HL077612; R01-HL093081; N01-HC95159-HC95169; UL1-TR000040 / National Institutes of Health/National Heart, Lung and Blood Institute Quebec Health Research Fund (BMS)
Language: English
Date published: 04/20/2017
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Radiology; Internal Medicine
Record Identifier: 9984240439402771

Metrics

13 Record Views

47 Times Cited - Web of Science