Journal article
Pulsatile spinal cord surrogate for intradural neuromodulation studies
Journal of medical engineering & technology, Vol.36(1), pp.22-25
03/01/2012
DOI: 10.3109/03091902.2011.632061
PMID: 22188575
Abstract
We have designed, built and tested a novel spinal cord surrogate that mimics the low-amplitude cardiac-driven pulsations of the human spinal cord, for use in developing intradural implants to be used in a novel form of neuromodulation for the treatment of intractable pain and motor system dysfunction. The silicone surrogate has an oval cross section, 10 mm major axis × 6 mm minor axis, and incorporates a 3 mm diameter × 3 cm long angioplasty balloon that serves as the pulsation actuator. When pneumatically driven at 1 Hz and 1.5 atmospheres (≈ 1140 mm Hg), the surrogate's diametric pulsation is ≈ 100 μm, which corresponds well to in vivo observations. The applications for this surrogate are presented and discussed.
Details
- Title: Subtitle
- Pulsatile spinal cord surrogate for intradural neuromodulation studies
- Creators
- S Wilson - Department of Neurosurgery, University of Iowa Hospitals and ClinicsM. A Howard - Department of Neurosurgery, University of Iowa Hospitals and ClinicsJ. D Rossen - Department of Internal Medicine, University of Iowa Hospitals and ClinicsT. J Brennan - Department of Anesthesia, University of Iowa Hospitals and ClinicsB. D Dalm - Department of Neurosurgery, University of Iowa Hospitals and ClinicsN. S Dahdaleh - Department of Neurosurgery, University of Iowa Hospitals and ClinicsM Utz - Department of Mechanical and Aerospace Engineering, University of VirginiaG. T Gillies - Department of Mechanical and Aerospace Engineering, University of Virginia
- Resource Type
- Journal article
- Publication Details
- Journal of medical engineering & technology, Vol.36(1), pp.22-25
- Publisher
- Taylor & Francis
- DOI
- 10.3109/03091902.2011.632061
- PMID
- 22188575
- ISSN
- 0309-1902
- eISSN
- 1464-522X
- Language
- English
- Date published
- 03/01/2012
- Academic Unit
- Neurology; Iowa Neuroscience Institute; Cardiovascular Medicine; Anesthesia; Neurosurgery; Otolaryngology; Internal Medicine
- Record Identifier
- 9984013202302771
Metrics
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