Pulsatile versus nonpulsatile flow. No difference in cerebral blood flow or metabolism during normothermic cardiopulmonary bypass in rabbits

B J Hindman; F Dexter; T Smith; J Cutkomp

doi:10.1097/00000542-199501000-00029

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Pulsatile versus nonpulsatile flow. No difference in cerebral blood flow or metabolism during normothermic cardiopulmonary bypass in rabbits

Journal article

Peer reviewed

Pulsatile versus nonpulsatile flow. No difference in cerebral blood flow or metabolism during normothermic cardiopulmonary bypass in rabbits

B J Hindman, F Dexter, T Smith and J Cutkomp

Anesthesiology, Vol.82(1), pp.241-250

01/1995

DOI: 10.1097/00000542-199501000-00029

PMID: 7832307

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Abstract

Although pulsatile and nonpulsatile cardiopulmonary bypass (CPB) do not differentially affect cerebral blood flow (CBF) or metabolism during hypothermia, studies suggest pulsatile CPB may result in greater CBF than nonpulsatile CPB under normothermic conditions. Consequently, nonpulsatile flow may contribute to poorer neurologic outcome observed in some studies of normothermic CPB. This study compared CBF and cerebral metabolic rate for oxygen (CMRO2) between pulsatile and nonpulsatile CPB at 37 degrees C. In experiment A, 16 anesthetized New Zealand white rabbits were randomized to one of two pulsatile CPB groups based on pump systolic ejection period (100 and 140 ms, respectively). Each animal was perfused at 37 degrees C for 30 min at each of two pulse rates (150 and 250 pulse/min, respectively). This scheme created four different arterial pressure waveforms. At the end of each perfusion period, arterial pressure waveform, arterial and cerebral venous oxygen content, CBF (microspheres), and CMRO2 (Fick) were measured. In experiment B, 22 rabbits were randomized to pulsatile (100-ms ejection period, 250 pulse/min) or nonpulsatile CPB at 37 degrees C. At 30 and 60 min of CPB, physiologic measurements were made as before. In experiment A, CBF and CMRO2 were independent of ejection period and pulse rate. Thus, all four waveforms were physiologically equivalent. In experiment B, CBF did not differ between pulsatile and nonpulsatile CPB (72 +/- 6 vs. 77 +/- 9 ml.100 g-1.min-1, respectively (median +/- quartile deviation)). CMRO2 did not differ between pulsatile and nonpulsatile CPB (4.7 +/- 0.5 vs. 4.1 +/- 0.6 ml O2.100 g-1.min-1, respectively) and decreased slightly (0.4 +/- 0.4 ml O2.100 g-1.min-1) between measurements. During CPB in rabbits at 37 degrees C, neither CBF nor CMRO2 is affected by arterial pulsation. The absence of pulsation per se is not responsible for the small decreases in CMRO2 observed during CPB.

Rabbits

Pulsatile Flow

Oxygen Consumption

Fentanyl

Cerebrovascular Circulation

Cardiopulmonary Bypass

Random Allocation

Brain - physiology

Brain - metabolism

Microspheres

Animals

Anesthesia

Hemodynamics

Diazepam

Details

Title: Subtitle: Pulsatile versus nonpulsatile flow. No difference in cerebral blood flow or metabolism during normothermic cardiopulmonary bypass in rabbits
Creators: B J Hindman - Department of Anesthesia, University of Iowa, College of Medicine, Iowa City 52242
F Dexter
T Smith
J Cutkomp
Resource Type: Journal article
Publication Details: Anesthesiology, Vol.82(1), pp.241-250
DOI: 10.1097/00000542-199501000-00029
PMID: 7832307
NLM abbreviation: Anesthesiology
ISSN: 0003-3022
eISSN: 1528-1175
Publisher: United States
Grant note: 1RO1 HL47159 / NHLBI NIH HHS
Language: English
Date published: 01/1995
Academic Unit: Health Management and Policy; Anesthesia
Record Identifier: 9983806274102771

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