Putative Multifunctional Signature of Lung Metastases in Dedifferentiated Chondrosarcoma

Sergey Malchenko; Elisabeth A Seftor; Yuri Nikolsky; Susan L Hasegawa; Sean Kuo; Jeff W Stevens; Stas Poyarkov; Tatiana Nikolskaya; Tamara Kucaba; Min Wang; Hakim Abdulkawy; Thomas Casavant; Jose Morcuende; Joseph Buckwalter; Raymond Hohl; Barry DeYoung; Kemp Kernstine; Maria de Fatima Bonaldo; Mary J. C Hendrix; Vera Maria F. C Soares; Marcelo B Soares

doi:10.1155/2012/820254

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Putative Multifunctional Signature of Lung Metastases in Dedifferentiated Chondrosarcoma

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Putative Multifunctional Signature of Lung Metastases in Dedifferentiated Chondrosarcoma

Sergey Malchenko, Elisabeth A Seftor, Yuri Nikolsky, Susan L Hasegawa, Sean Kuo, Jeff W Stevens, Stas Poyarkov, Tatiana Nikolskaya, Tamara Kucaba, Min Wang, …

Sarcoma, Vol.2012, 820254

2012

DOI: 10.1155/2012/820254

PMCID: PMC3289931

PMID: 22448124

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Abstract

Chondrosarcomas are among the most malignant skeletal tumors. Dedifferentiated chondrosarcoma is a highly aggressive subtype of chondrosarcoma, with lung metastases developing within a few months of diagnosis in 90% of patients. In this paper we performed comparative analyses of the transcriptomes of five individual metastatic lung lesions that were surgically resected from a patient with dedifferentiated chondrosarcoma. We document for the first time a high heterogeneity of gene expression profiles among the individual lung metastases. Moreover, we reveal a signature of “multifunctional” genes that are expressed in all metastatic lung lesions. Also, for the first time, we document the occurrence of massive macrophage infiltration in dedifferentiated chondrosarcoma lung metastases.

Details

Title: Subtitle: Putative Multifunctional Signature of Lung Metastases in Dedifferentiated Chondrosarcoma
Creators: Sergey Malchenko - Cancer Biology and Epigenomics Program, Children’s Memorial Research Center, and Department of Pediatrics, Northwestern University Feinberg School of Medicine, 2430 N. Halstead Street, Chicago, IL 60614, USA
Elisabeth A Seftor - Cancer Biology and Epigenomics Program, Children’s Memorial Research Center, and Department of Pediatrics, Northwestern University Feinberg School of Medicine, 2430 N. Halstead Street, Chicago, IL 60614, USA
Yuri Nikolsky - GeneGo, Inc., 500 Renaissance Drive, No. 106, St. Joseph, MI 49085, USA
Susan L Hasegawa - Department of Pathology and Laboratory Medicine, Children’s Memorial Hospital 2300 Children’s Plaza, Chicago, IL 60614, USA
Sean Kuo - Center for Bioinformatics and Computation Biology, University of Iowa, 5316 Seamans Center, Iowa City, IA 52242, USA
Jeff W Stevens - Department of Orthopaedics and Rehabilitation, University of Iowa, 200 Hawkins Drive, Iowa City, IA 52242, USA
Stas Poyarkov - Vavilov Institute for General Genetics, Russian Academy of Sciences, 3 Gubkina Street, Moscow 117093, Russia
Tatiana Nikolskaya - Vavilov Institute for General Genetics, Russian Academy of Sciences, 3 Gubkina Street, Moscow 117093, Russia
Tamara Kucaba - Department of Urology, University of Iowa, 200 Hawkins Drive, Iowa City, IA 52242, USA
Min Wang - Cancer Biology and Epigenomics Program, Children’s Memorial Research Center, and Department of Pediatrics, Northwestern University Feinberg School of Medicine, 2430 N. Halstead Street, Chicago, IL 60614, USA
Hakim Abdulkawy - University of Iowa
Thomas Casavant - University of Iowa, Electrical and Computer Engineering
Jose Morcuende - University of Iowa, Orthopedics and Rehabilitation
Joseph Buckwalter - University of Iowa, Orthopedics and Rehabilitation
Raymond Hohl - University of Iowa, Internal Medicine
Barry DeYoung - Department of Surgical Pathology, University of Iowa, 200 Hawkins Drive, Iowa City, IA 52242, USA
Kemp Kernstine - Lung Cancer and Thoracic Oncology Program, Beckman Research Institute, City of Hope, 1500 East Duarte Road, Duarte, CA 91010, USA
Maria de Fatima Bonaldo - Cancer Biology and Epigenomics Program, Children’s Memorial Research Center, and Department of Pediatrics, Northwestern University Feinberg School of Medicine, 2430 N. Halstead Street, Chicago, IL 60614, USA
Mary J. C Hendrix - Northwestern University
Vera Maria F. C Soares - Department of Pediatrics, University of Iowa, 200 Hawkins Drive, Iowa City, IA 52242, USA
Marcelo B Soares - Cancer Biology and Epigenomics Program, Children’s Memorial Research Center, and Department of Pediatrics, Northwestern University Feinberg School of Medicine, 2430 N. Halstead Street, Chicago, IL 60614, USA
Resource Type: Journal article
Publication Details: Sarcoma, Vol.2012, 820254
DOI: 10.1155/2012/820254
PMID: 22448124
PMCID: PMC3289931
NLM abbreviation: Sarcoma
ISSN: 1357-714X
eISSN: 1369-1643
Grant note: DOI: 10.13039/100000054, name: National Cancer Institute, award: 99SX131A, R37CA59702
Language: English
Date published: 2012
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Electrical and Computer Engineering; Stead Family Department of Pediatrics; Orthopedics and Rehabilitation; Internal Medicine
Record Identifier: 9984040553102771

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