Quadriceps weakness predicts risk for knee joint space narrowing in women in the MOST cohort

N.A Segal; N.A Glass; J Torner; M Yang; D.T Felson; L Sharma; M Nevitt; C.E Lewis

doi:10.1016/j.joca.2010.02.002

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Quadriceps weakness predicts risk for knee joint space narrowing in women in the MOST cohort

Journal article

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Quadriceps weakness predicts risk for knee joint space narrowing in women in the MOST cohort

N.A Segal, N.A Glass, J Torner, M Yang, D.T Felson, L Sharma, M Nevitt and C.E Lewis

Osteoarthritis and cartilage, Vol.18(6), pp.769-775

2010

DOI: 10.1016/j.joca.2010.02.002

PMCID: PMC2873062

PMID: 20188686

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Abstract

Quadriceps weakness has been reported with incident but not progressive knee osteoarthritis (OA) in longitudinal studies. This study examined the relationship between quadriceps strength and worsening of knee joint space narrowing (JSN) over 30 months. Longitudinal, observational study of adults aged 50–79 years with OARSI JSN score <3 at baseline. Baseline measures included bilateral weight-bearing fixed flexion radiographs, isokinetic concentric quadriceps and hamstring strength, height and weight, and physical activity. Hamstring:quadriceps (H:Q) strength ratios also were evaluated. Worsening was defined as an increase in JSN score in the tibiofemoral and/or patellofemoral compartments on 30-month radiographs or total knee replacement. Knee-based analyses used generalized estimating equations, stratified by sex, to assess relationships between strength and knee JSN while controlling for covariance between knees within subjects as well as age, body mass index (BMI), history of knee injury and/or surgery, physical activity level and alignment. 3856 knees (2254 females and 1602 males) with JSN score <3 at baseline and no missing follow-up data were included. Mean ± SD age was 62.2 ± 7.7 in women and 61.6 ± 8.1 in men. Women in the lowest tertile of quadriceps strength had an increased risk of whole knee JSN (OR = 1.66, 95% CI = 1.26, 2.19) and tibiofemoral JSN (OR = 1.69, 95% CI = 1.26, 2.28). However, no associations were found between strength and JSN in men or H:Q < 0.6 and JSN in men or women. In women but not in men, quadriceps weakness was associated with increased risk for tibiofemoral and whole knee JSN.

Quadriceps muscle strength

Hamstring:quadriceps ratio

Knee osteoarthritis

Rehabilitation

Details

Title: Subtitle: Quadriceps weakness predicts risk for knee joint space narrowing in women in the MOST cohort
Creators: N.A Segal - The University of Iowa, Iowa City, IA, United States
N.A Glass - The University of Iowa, Iowa City, IA, United States
J Torner - The University of Iowa, Iowa City, IA, United States
M Yang - Boston University
D.T Felson - Boston University, Boston, MA, United States
L Sharma - Northwestern University Feinberg School of Medicine, Chicago, IL, United States
M Nevitt - University of California San Francisco, San Francisco, CA, United States
C.E Lewis - University of Alabama at Birmingham, Birmingham, AL, United States
Resource Type: Journal article
Publication Details: Osteoarthritis and cartilage, Vol.18(6), pp.769-775
DOI: 10.1016/j.joca.2010.02.002
PMID: 20188686
PMCID: PMC2873062
NLM abbreviation: Osteoarthritis Cartilage
ISSN: 1063-4584
eISSN: 1522-9653
Publisher: Elsevier Ltd
Grant note: name: NIH, award: AG18820, AG18832, AG18947, AG19069; name: Beeson Career Development Award, award: K23AG030945
Language: English
Date published: 2010
Academic Unit: Epidemiology; Orthopedics and Rehabilitation; Surgery; Injury Prevention Research Center; Neurosurgery
Record Identifier: 9983996077702771

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