Journal article
Quality control systems in cardiac aging
Ageing research reviews, Vol.23(Pt A), pp.101-115
09/2015
DOI: 10.1016/j.arr.2015.02.003
PMCID: PMC4686341
PMID: 25702865
Abstract
Cardiac aging is an intrinsic process that results in impaired cardiac function, along with cellular and molecular changes. These degenerative changes are intimately associated with quality control mechanisms. This review provides a general overview of the clinical and cellular changes which manifest in cardiac aging, and the quality control mechanisms involved in maintaining homeostasis and retarding aging. These mechanisms include autophagy, ubiquitin-mediated turnover, apoptosis, mitochondrial quality control and cardiac matrix homeostasis. Finally, we discuss aging interventions that have been observed to impact cardiac health outcomes. These include caloric restriction, rapamycin, resveratrol, GDF11, mitochondrial antioxidants and cardiolipin-targeted therapeutics. A greater understanding of the quality control mechanisms that promote cardiac homeostasis will help to understand the benefits of these interventions, and hopefully lead to further improved therapeutic modalities.
Details
- Title: Subtitle
- Quality control systems in cardiac aging
- Creators
- Ellen K Quarles - University of Washington School of Medicine, Department of Pathology, Box 357470, Seattle, WA 98195-7470, United States. Electronic address: equarles@gmail.comDao-Fu Dai - University of Washington School of Medicine, Department of Pathology, Box 357470, Seattle, WA 98195-7470, United States. Electronic address: ddaofu@u.washington.eduAutumn Tocchi - University of Washington School of Medicine, Department of Pathology, Box 357470, Seattle, WA 98195-7470, United States. Electronic address: uw.tocchi@gmail.comNathan Basisty - University of Washington School of Medicine, Department of Pathology, Box 357470, Seattle, WA 98195-7470, United States. Electronic address: nbasisty@uw.eduLemuel Gitari - University of Washington School of Medicine, Department of Pathology, Box 357470, Seattle, WA 98195-7470, United States. Electronic address: mlemuel@uw.eduPeter S Rabinovitch - University of Washington School of Medicine, Department of Pathology, Box 357470, Seattle, WA 98195-7470, United States. Electronic address: petersr@u.washington.edu
- Resource Type
- Journal article
- Publication Details
- Ageing research reviews, Vol.23(Pt A), pp.101-115
- DOI
- 10.1016/j.arr.2015.02.003
- PMID
- 25702865
- PMCID
- PMC4686341
- NLM abbreviation
- Ageing Res Rev
- ISSN
- 1568-1637
- eISSN
- 1872-9649
- Publisher
- England
- Grant note
- T32 AG000057 / NIA NIH HHS P01 AG001751 / NIA NIH HHS
- Language
- English
- Date published
- 09/2015
- Academic Unit
- Pathology; Iowa Neuroscience Institute; Radiation Oncology
- Record Identifier
- 9984047611802771
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