Journal article
Quality of Life for 19,114 participants in the ASPREE (ASPirin in Reducing Events in the Elderly) study and their association with sociodemographic and modifiable lifestyle risk factors
Quality of life research, Vol.28(4), pp.935-946
04/2019
DOI: 10.1007/s11136-018-2040-z
PMCID: PMC6924574
PMID: 30411180
Abstract
To explore the relationship between sociodemographic and lifestyle variables with health-related quality of life (HRQoL) of a large cohort of 'healthy' older individuals.
The sample included individuals aged 65+ years from Australia (N = 16,703) and the USA (N = 2411) enrolled in the ASPirin in Reducing Events in the Elderly (ASPREE) multicentre placebo-controlled trial study and free of cardiovascular disease, dementia, serious physical disabilities or 'fatal' illnesses. The associations with the physical (PCS) and mental component scores (MCS) of HRQoL (SF-12 questionnaire) were explored using multiple linear regression models from data collected at baseline (2010-2014).
The adjusted PCS mean was slightly higher in the USA (49.5 ± 9.1) than Australia (48.2 ± 11.6; p < 0.001), but MCS was similar in both samples (55.7 ± 7.5 and 55.7 ± 9.6, respectively; p = 0.603). Males, younger participants, better educated, more active individuals, or those currently drinking 1-2 alcoholic drinks/day showed a better HRQoL (results more evident for PCS than MCS), while current heavy smokers had the lowest physical HRQoL in both countries. Neither age, walking time, nor alcohol intake was associated with MCS in either cohort.
Baseline HRQoL of ASPREE participants was higher than that reported in population-based studies of older individuals, but the associations between sociodemographic and lifestyle variables were consistent with the published literature. As the cohort ages and develops chronic diseases, ASPREE will be able to document HRQoL changes.
Details
- Title: Subtitle
- Quality of Life for 19,114 participants in the ASPREE (ASPirin in Reducing Events in the Elderly) study and their association with sociodemographic and modifiable lifestyle risk factors
- Creators
- Nigel P Stocks - University of AdelaideDavid A González-Chica - University of AdelaideRobyn L Woods - Monash UniversityJessica E Lockery - Monash UniversityRory S J Wolfe - Monash UniversityAnne M Murray - Hennepin County Medical CenterBrenda Kirpach - Hennepin County Medical CenterRaj C Shah - Rush University Medical CenterMark R Nelson - Monash UniversityChristopher M Reid - Monash UniversityMichael E Ernst - University of IowaJohn J McNeil - Monash UniversityASPREE Investigator Group
- Resource Type
- Journal article
- Publication Details
- Quality of life research, Vol.28(4), pp.935-946
- DOI
- 10.1007/s11136-018-2040-z
- PMID
- 30411180
- PMCID
- PMC6924574
- ISSN
- 0962-9343
- eISSN
- 1573-2649
- Grant note
- U01 AG029824 / NIA NIH HHS U01AG029824 / NIA NIH HHS 334047 / National Health and Medical Research Council of Australia (AU) U19 AG062682 / NIA NIH HHS 1127060 / National Health and Medical Research Council of Australia (AU)
- Language
- English
- Date published
- 04/2019
- Academic Unit
- Family and Community Medicine; Pharmacy Practice and Science
- Record Identifier
- 9984297346102771
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