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Quality of life after pharmacomechanical catheter-directed thrombolysis for proximal deep venous thrombosis
Journal article   Open access

Quality of life after pharmacomechanical catheter-directed thrombolysis for proximal deep venous thrombosis

Susan R Kahn, Jim A Julian, Clive Kearon, Chu-Shu Gu, David J Cohen, Elizabeth A Magnuson, Anthony J Comerota, Samuel Z Goldhaber, Michael R Jaff, Mahmood K Razavi, …
Journal of vascular surgery. Venous and lymphatic disorders (New York, NY), Vol.8(1), pp.8-23.e18
01/2020
DOI: 10.1016/j.jvsv.2019.03.023
PMCID: PMC7681916
PMID: 31843251
url
https://doi.org/10.1016/j.jvsv.2019.03.023View
Published (Version of record) Open Access

Abstract

After deep venous thrombosis (DVT), many patients have impaired quality of life (QOL). We aimed to assess whether pharmacomechanical catheter-directed thrombolysis (PCDT) improves short-term or long-term QOL in patients with proximal DVT and whether QOL is related to extent of DVT. The Acute Venous Thrombosis: Thrombus Removal with Adjunctive Catheter-Directed Thrombolysis (ATTRACT) trial was an assessor-blinded randomized trial that compared PCDT with no PCDT in patients with DVT of the femoral, common femoral, or iliac veins. QOL was assessed at baseline and 1 month, 6 months, 12 months, 18 months, and 24 months using the Venous Insufficiency Epidemiological and Economic Study on Quality of Life/Symptoms (VEINES-QOL/Sym) disease-specific QOL measure and the 36-Item Short Form Health Survey (SF-36) physical component summary (PCS) and mental component summary general QOL measures. Change in QOL scores from baseline to assessment time were compared in the PCDT and no PCDT treatment groups overall and in the iliofemoral DVT and femoral-popliteal DVT subgroups. Of 692 ATTRACT patients, 691 were analyzed (mean age, 53 years; 62% male; 57% iliofemoral DVT). VEINES-QOL change scores were greater (ie, better) in PCDT vs no PCDT from baseline to 1 month (difference, 5.7; P = .0006) and from baseline to 6 months (5.1; P = .0029) but not for other intervals. SF-36 PCS change scores were greater in PCDT vs no PCDT from baseline to 1 month (difference, 2.4; P = .01) but not for other intervals. Among iliofemoral DVT patients, VEINES-QOL change scores from baseline to all assessments were greater in the PCDT vs no PCDT group; this was statistically significant in the intention-to-treat analysis at 1 month (difference, 10.0; P < .0001) and 6 months (8.8; P < .0001) and in the per-protocol analysis at 18 months (difference, 5.8; P = .0086) and 24 months (difference, 6.6; P = .0067). SF-36 PCS change scores were greater in PCDT vs no PCDT from baseline to 1 month (difference, 3.2; P = .0010) but not for other intervals. In contrast, in femoral-popliteal DVT patients, change scores from baseline to all assessments were similar in the PCDT and no PCDT groups. Among patients with proximal DVT, PCDT leads to greater improvement in disease-specific QOL than no PCDT at 1 month and 6 months but not later. In patients with iliofemoral DVT, PCDT led to greater improvement in disease-specific QOL during 24 months.
 Quality of Life United States Adult Female Femoral Vein - physiopathology Fibrinolytic Agents - administration & dosage Fibrinolytic Agents - adverse effects Humans Iliac Vein - physiopathology Male Mechanical Thrombolysis - adverse effects Middle Aged Surveys and Questionnaires Thrombolytic Therapy - adverse effects Time Factors Treatment Outcome Venous Thrombosis - diagnosis Venous Thrombosis - physiopathology Venous Thrombosis - therapy

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