Journal article
Quality of life among long-term survivors of advanced stage ovarian cancer: A cross-sectional approach
Gynecologic oncology, Vol.146(1), pp.101-108
07/2017
DOI: 10.1016/j.ygyno.2017.05.008
PMCID: PMC5618102
PMID: 28527672
Abstract
•QOL of long-term advanced-stage ovarian cancer survivors is relatively good.•Survivors with multiple recurrences reported more compromised QOL.•Low levels of exercise were reported by 43% of long-term survivors.•Among these survivors, 52% were overweight or obese.•Sexual health concerns are common in long-term survivors.
Long-term survival of women with advanced-stage ovarian cancer is relatively rare. Little is known about quality of life (QOL) and survivorship concerns of these women. Here, we describe QOL of women with advanced-stage ovarian cancer surviving for 8.5 years or longer and compare women with 0–1 recurrence to those with multiple recurrences.
Participants (n=56) recruited from 5 academic medical centers and the Ovarian Cancer Research Fund Alliance completed surveys regarding QOL (FACT-O), mood (CESD), social support (SPS), physical activity (IPAQ-SF), diet, and clinical characteristics. Median survival was 14.0 years (range 8.8–33.3).
QOL and psychological adjustment of long-term survivors was relatively good, with mean FACT-G scores (multiple recurrences: 80.81±13.95; 0–1 recurrence: 89.05 ±10.80) above norms for healthy community samples (80.1±18.1). Survivors with multiple recurrences reported more compromised QOL in domains of physical and emotional well-being (p <.05), and endorsed a variety of physical and emotional concerns compared to survivors with 0–1 recurrence. Difficulties in sexual functioning were common in both groups. Almost half (43%) of the survivors reported low levels of physical activity.
Overall, women with advanced-stage ovarian cancer who have survived at least 8.5 years report good QOL and psychological adjustment. QOL of survivors with multiple recurrences is somewhat impaired compared to those with 0–1 recurrence. Limitations include a possible bias towards participation by healthier survivors, thus under-representing the level of compromise in long-term survivors. Health care practitioners should be alert to psychosocial issues faced by these long-term survivors to provide interventions that enhance QOL.
Details
- Title: Subtitle
- Quality of life among long-term survivors of advanced stage ovarian cancer: A cross-sectional approach
- Creators
- Susan K Lutgendorf - Department of Psychological and Brain Sciences, University of Iowa, Iowa City, IA, USAEileen Shinn - Department of Behavioral Science, Division of OVP, Cancer Prevention and Population Sciences, The University of Texas, M.D. Anderson Cancer Center, Houston, TX, USAJeanne Carter - Gynecology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USASusan Leighton - Ovarian Cancer Research Fund Alliance, Washington, DC, United StatesKeith Baggerly - Department of Bioinformatics and Computational Biology, Division of Quantitative Sciences, University of Texas, M.D. Anderson Cancer Center, Houston, TX, USAMichele Guindani - Department of Biostatistics, Division of Quantitative Sciences, University of Texas, M.D. Anderson Cancer Center, Houston, TX, USABryan Fellman - Department of Biostatistics, Division of Quantitative Sciences, University of Texas, M.D. Anderson Cancer Center, Houston, TX, USAMarianne Matzo - College of Family Medicine, Stephenson Oklahoma Cancer Center, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USAGeorge M Slavich - Cousins Center for Psychoneuroimmunology, Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA, USAMarc T Goodman - Cancer Prevention and Genetics Program, Samuel Oschin Comprehensive Cancer Institute, Department of Obstetrics and Gynecology, Cedars-Sinai Medical Center, Los Angeles, CA, USAWilliam Tew - Gynecologic Medical Oncology Service, Memorial Sloan Kettering Cancer Center, Weill Cornell Medicine, New York, NY, USAJenny Lester - Women's Cancer Program, Samuel Oschin Comprehensive Cancer Institute, Department of Obstetrics and Gynecology, Cedars-Sinai Medical Center, Los Angeles, CA, USAKathleen M Moore - Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Stephenson Oklahoma Cancer Center, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USABeth Y Karlan - Women's Cancer Program, Samuel Oschin Comprehensive Cancer Institute, Department of Obstetrics and Gynecology, Cedars-Sinai Medical Center, Los Angeles, CA, USADouglas A Levine - Gynecology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USAAnil K Sood - Department of Gynecologic Oncology, University of Texas, M.D. Anderson Cancer Center, Houston, TX, USA
- Resource Type
- Journal article
- Publication Details
- Gynecologic oncology, Vol.146(1), pp.101-108
- DOI
- 10.1016/j.ygyno.2017.05.008
- PMID
- 28527672
- PMCID
- PMC5618102
- NLM abbreviation
- Gynecol Oncol
- ISSN
- 0090-8258
- eISSN
- 1095-6859
- Publisher
- Elsevier Inc
- Grant note
- Ovarian Cancer Research Fund Alliance (http://dx.doi.org/10.13039/100001282)
- Language
- English
- Date published
- 07/2017
- Academic Unit
- Psychological and Brain Sciences; Iowa Neuroscience Institute; Obstetrics and Gynecology; Urology
- Record Identifier
- 9984002415002771
Metrics
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