Journal article
Quality of life among men with low-risk prostate cancer during the first year following diagnosis: the PREPARE prospective cohort study
Translational behavioral medicine, Vol.8(2), pp.156-165
03/01/2018
DOI: 10.1093/tbm/ibx005
PMCID: PMC6256951
PMID: 29425377
Abstract
As many as 40% of men diagnosed with prostate cancer have low-risk disease, which results in the need to decide whether to undergo active treatment (AT) or active surveillance (AS). The treatment decision can have a significant effect on general and prostate-specific quality of life (QOL). The purpose of this study was to assess the QOL among men with low-risk prostate cancer during the first year following diagnosis. In a prospective cohort study, we conducted pretreatment telephone interviews (N = 1,139; 69.3% response rate) with low-risk PCa patients (PSA ≤ 10, Gleason ≤ 6) and a follow-up assessment 6-10 months postdiagnosis (N = 1057; 93%). We assessed general depression, anxiety, and physical functioning, prostate-specific anxiety, and prostate-specific QOL at both interviews. Clinical variables were obtained from the medical record. Men were 61.7 (SD = 7.2) years old, 82% white, 39% had undergone AT (surgery or radiation), and 61.0% had begun AS. Linear regression analyses revealed that at follow-up, the AS group reported significantly better sexual, bowel, urinary, and general physical function (compared to AT), and no difference in depression. However, the AS group did report greater general anxiety and prostate-specific anxiety at follow-up, compared to AT. Among men with low-risk PCa, adjusting for pretreatment functioning, the AS group reported better prostate-related QOL, but were worse off on general and prostate-specific anxiety compared to men on AT. These results suggest that, within the first year postdiagnosis, men who did not undergo AT may require additional support in order to remain comfortable with this decision and to continue with AS when it is clinically indicated.
Details
- Title: Subtitle
- Quality of life among men with low-risk prostate cancer during the first year following diagnosis: the PREPARE prospective cohort study
- Creators
- Kathryn L Taylor - Cancer Prevention and Control Program, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USAGeorge Luta - Department of Biostatistics, Bioinformatics, and Biomathematics, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USARichard M Hoffman - Holden Comprehensive Cancer, University of Iowa, Iowa City, IA, USAKimberly M Davis - Cancer Prevention and Control Program, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USATania Lobo - Cancer Prevention and Control Program, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USAYingjun Zhou - Cancer Prevention and Control Program, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USAAmethyst Leimpeter - Division of Research, Kaiser Permanente Northern California, Oakland, CA, USAJun Shan - Division of Research, Kaiser Permanente Northern California, Oakland, CA, USARoxanne E Jensen - Cancer Prevention and Control Program, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USADavid S Aaronson - Department of Urology, Kaiser Permanente East Bay, Oakland, CA, USAStephen K Van Den Eeden - Division of Research, Kaiser Permanente Northern California, Oakland, CA, USA
- Resource Type
- Journal article
- Publication Details
- Translational behavioral medicine, Vol.8(2), pp.156-165
- DOI
- 10.1093/tbm/ibx005
- PMID
- 29425377
- PMCID
- PMC6256951
- ISSN
- 1869-6716
- eISSN
- 1613-9860
- Grant note
- P30 CA086862 / NCI NIH HHS R01 CA155578 / NCI NIH HHS
- Language
- English
- Date published
- 03/01/2018
- Academic Unit
- Epidemiology; General Internal Medicine; Internal Medicine
- Record Identifier
- 9984094524602771
Metrics
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