Journal article
Quality of life at 6 months in the Idiopathic Intracranial Hypertension Treatment Trial
Neurology, Vol.87(18), pp.1871-1877
11/01/2016
DOI: 10.1212/WNL.0000000000003280
PMCID: PMC5100710
PMID: 27694262
Abstract
To examine the changes in vision-specific and overall health-related quality of life (QOL) at 6 months in participants with idiopathic intracranial hypertension (IIH) and mild visual loss enrolled in the Idiopathic Intracranial Hypertension Treatment Trial (IIHTT) and to determine the signs and symptoms of IIH that mediate the effect of acetazolamide on QOL. We assessed QOL using the National Eye Institute Visual Function Questionnaire-25 (NEI-VFQ-25), the 10-Item NEI-VFQ-25 Neuro-Ophthalmic Supplement, and the 36-Item Short Form Health Survey (SF-36). We examined associations among changes in QOL measures over 6 months, treatment status, and changes in signs and symptoms using linear and structural equation models. Among the 165 participants with IIH (86 randomized to acetazolamide, 79 to placebo), beneficial effects of acetazolamide were seen on all QOL scales evaluated, as well as on the Near Activities (5.60 points, p = 0.03), Social Functioning (3.85 points, p = 0.04), and Mental Health (9.82, p = 0.04) subscales of the NEI-VFQ-25. Positive acetazolamide-related effects on QOL appeared to be primarily mediated by improvements in visual field, neck pain, pulsatile tinnitus, and dizziness/vertigo that outweighed the side effects of acetazolamide. The marked reductions in baseline QOL seen among patients with mild visual loss from IIH are improved by treatment with acetazolamide. When combined with acetazolamide-associated improvements in visual field and other aspects of IIH, our findings with respect to QOL provide further support from the IIHTT in favor of acetazolamide to augment a dietary intervention in the treatment of IIH with mild visual loss (clinicaltrials.gov: NCT01003639).
Details
- Title: Subtitle
- Quality of life at 6 months in the Idiopathic Intracranial Hypertension Treatment Trial
- Creators
- Beau B Bruce - Emory UniversityKathleen B Digre - University of UtahMichael P McDermott - University of Rochester Medical CenterEleanor B Schron - National Eye InstituteMichael Wall - University of Iowa, Carver College of MedicineNORDIC Idiopathic Intracranial Hypertension Study Group
- Resource Type
- Journal article
- Publication Details
- Neurology, Vol.87(18), pp.1871-1877
- Publisher
- United States
- DOI
- 10.1212/WNL.0000000000003280
- PMID
- 27694262
- PMCID
- PMC5100710
- ISSN
- 1526-632X
- eISSN
- 1526-632X
- Language
- English
- Date published
- 11/01/2016
- Academic Unit
- Neurology; Ophthalmology and Visual Sciences
- Record Identifier
- 9983979973302771
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