Journal article
Quantification and toxicity of group A streptococcal pyrogenic exotoxins in an animal model of toxic shock syndrome-like illness
Journal of clinical microbiology, Vol.27(8), pp.1890-1892
08/1989
DOI: 10.1128/JCM.27.8.1890-1892.1989
PMCID: PMC267693
PMID: 2504778
Abstract
Toxic shock-like syndrome isolates of group A streptococci were evaluated for production of pyrogenic exotoxins (also called SPEs, scarlet fever toxins, and erythrogenic toxins). The isolates were consecutively obtained during 1987 and 1988. Of these isolates, 23 of 26 made SPE type A, 10 of 26 made SPE B, and 8 of 26 made SPE C. SPE A was produced in significantly greater amounts than SPEs B and C (3.2 micrograms/ml of culture fluid compared with 0.7 and 0.6 microgram/ml, respectively). SPE A, administered in miniosmotic pumps implanted subcutaneously in rabbits, was significantly more toxic than SPE C; seven of eight rabbits succumbed after challenge with 150 or 300 micrograms of SPE A, compared with one of six after challenge with SPE C.
Details
- Title: Subtitle
- Quantification and toxicity of group A streptococcal pyrogenic exotoxins in an animal model of toxic shock syndrome-like illness
- Creators
- P K Lee - Department of Microbiology, University of Minnesota Medical School, Minneapolis 55455P M Schlievert - Department of Microbiology, University of Minnesota Medical School, Minneapolis 55455
- Resource Type
- Journal article
- Publication Details
- Journal of clinical microbiology, Vol.27(8), pp.1890-1892
- DOI
- 10.1128/JCM.27.8.1890-1892.1989
- PMID
- 2504778
- PMCID
- PMC267693
- ISSN
- 0095-1137
- eISSN
- 1098-660X
- Language
- English
- Date published
- 08/1989
- Academic Unit
- Microbiology and Immunology; Internal Medicine
- Record Identifier
- 9984001113402771
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