Journal article
Quantification of Brain Maturation and Growth Patterns in C57BL/6J Mice via Computational Neuroanatomy of Diffusion Tensor Images
Cerebral cortex (New York, N.Y. 1991), Vol.19(3), pp.675-687
03/2009
DOI: 10.1093/cercor/bhn112
PMCID: PMC3140198
PMID: 18653668
Abstract
Diffusion Tensor magnetic resonance imaging and computational neuroanatomy are used to quantify postnatal developmental patterns of C57BL/6J mouse brain. Changes in neuronal organization and myelination occurring as the brain matures into adulthood are examined, and a normative baseline is developed, against which transgenic mice may be compared in genotype–phenotype studies. In early postnatal days, gray matter–based cortical and hippocampal structures exhibit high water diffusion anisotropy, presumably reflecting the radial neuronal organization. Anisotropy drops rapidly within a week, indicating that the underlying brain tissue becomes more isotropic in orientation, possibly due to formation of a complex randomly intertwined web of dendrites. Gradual white matter anisotropy increase implies progressively more organized axonal pathways, likely reflecting the myelination of axons forming tightly packed fiber bundles. In contrast to the spatially complex pattern of tissue maturation, volumetric growth is somewhat uniform, with the cortex and the cerebellum exhibiting slightly more pronounced growth. Temporally, structural growth rates demonstrate an initial rapid volumetric increase in most structures, gradually tapering off to a steady state by about 20 days. Fiber maturation reaches steady state in about 10 days for the cortex, to 30–40 days for the corpus callosum, the hippocampus, and the internal and external capsules.
Details
- Title: Subtitle
- Quantification of Brain Maturation and Growth Patterns in C57BL/6J Mice via Computational Neuroanatomy of Diffusion Tensor Images
- Creators
- Sajjad Baloch - Department of Radiology, University of Pennsylvania, PA 19104, USARagini Verma - Department of Radiology, University of Pennsylvania, PA 19104, USAHao Huang - Department of Radiology, Johns Hopkins University, Baltimore, MD 21287, USAParmeshwar Khurd - Department of Radiology, University of Pennsylvania, PA 19104, USASarah Clark - School of Medicine, University of Maryland, Baltimore, MD 21250, USAPaul Yarowsky - School of Medicine, University of Maryland, Baltimore, MD 21250, USATed Abel - Department of Biology, University of Pennsylvania, PA 19104-6021, USASusumu Mori - Department of Radiology, Johns Hopkins University, Baltimore, MD 21287, USAChristos Davatzikos - Department of Radiology, University of Pennsylvania, PA 19104, USA
- Resource Type
- Journal article
- Publication Details
- Cerebral cortex (New York, N.Y. 1991), Vol.19(3), pp.675-687
- Publisher
- Oxford University Press
- DOI
- 10.1093/cercor/bhn112
- PMID
- 18653668
- PMCID
- PMC3140198
- ISSN
- 1047-3211
- eISSN
- 1460-2199
- Language
- English
- Date published
- 03/2009
- Academic Unit
- Molecular Physiology and Biophysics; Psychiatry; Psychological and Brain Sciences; Iowa Neuroscience Institute; Neuroscience and Pharmacology; Biochemistry and Molecular Biology
- Record Identifier
- 9984065737902771
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