Quantification of idiopathic pulmonary fibrosis using computed tomography and histology

H. O COXSON; J. C HOGG; J. R MAYO; H BEHZAD; K. P WHITTALL; D. A SCHWARTZ; P. G HARTLEY; J. R GALVIN; J. S WILSON; G. W HUNNINGHAKE

doi:10.1164/ajrccm.155.5.9154871

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Quantification of idiopathic pulmonary fibrosis using computed tomography and histology

Journal article

Peer reviewed

Quantification of idiopathic pulmonary fibrosis using computed tomography and histology

H. O COXSON, J. C HOGG, J. R MAYO, H BEHZAD, K. P WHITTALL, D. A SCHWARTZ, P. G HARTLEY, J. R GALVIN, J. S WILSON and G. W HUNNINGHAKE

American journal of respiratory and critical care medicine, Vol.155(5), pp.1649-1656

1997

DOI: 10.1164/ajrccm.155.5.9154871

PMID: 9154871

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Abstract

We used computed tomography (CT) and histologic analysis to quantify lung structure in idiopathic pulmonary fibrosis (IPF). CT scans were obtained from IPF and control patients and lung volumes were estimated from measurements of voxel size, and X-ray attenuation values of each voxel. Quantitative estimates of lung structure were obtained from biopsies obtained from diseased and normal CT regions using stereologic methods. CT density was used to calculate the proportion of tissue and air, and this value was used to correct the biopsy specimens to the level of inflation during the CT scan. The data show that IPF is associated with a reduction in airspace volume with no change in tissue volume or weight compared with control lungs. Lung surface area decreased two-thirds (p < 0.001) and mean parenchymal thickness increased tenfold (p < 0.001). An exudate of fluid and cells was present in the airspace of the diseased lung regions and the number of inflammatory cells, collagen, and proteoglycans was increased per 100 g of tissue in IPF. We conclude that IPF reorganized lung tissue content causing a loss of airspace and surface area without increasing the total lung tissue.

Biological and medical sciences

Medical sciences

Respiratory system : syndromes and miscellaneous diseases

Pneumology

Details

Title: Subtitle: Quantification of idiopathic pulmonary fibrosis using computed tomography and histology
Creators: H. O COXSON - Department of Radiology, Vancouver Hospital, Vancouver, British Columbia, Canada
J. C HOGG - Department of Radiology, Vancouver Hospital, Vancouver, British Columbia, Canada
J. R MAYO - Department of Radiology, Vancouver Hospital, Vancouver, British Columbia, Canada
H BEHZAD - Department of Radiology, Vancouver Hospital, Vancouver, British Columbia, Canada
K. P WHITTALL - Department of Radiology, Vancouver Hospital, Vancouver, British Columbia, Canada
D. A SCHWARTZ - Department of Radiology, Vancouver Hospital, Vancouver, British Columbia, Canada
P. G HARTLEY - Department of Radiology, Vancouver Hospital, Vancouver, British Columbia, Canada
J. R GALVIN - Department of Radiology, Vancouver Hospital, Vancouver, British Columbia, Canada
J. S WILSON - Department of Radiology, Vancouver Hospital, Vancouver, British Columbia, Canada
G. W HUNNINGHAKE - Department of Radiology, Vancouver Hospital, Vancouver, British Columbia, Canada
Resource Type: Journal article
Publication Details: American journal of respiratory and critical care medicine, Vol.155(5), pp.1649-1656
Publisher: American Lung Association
DOI: 10.1164/ajrccm.155.5.9154871
PMID: 9154871
ISSN: 1073-449X
eISSN: 1535-4970
Language: English
Date published: 1997
Academic Unit: Pulmonary, Critical Care, and Occupational Medicine; Occupational and Environmental Health; Internal Medicine
Record Identifier: 9984094716702771

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