Journal article
Quantification of neonatal lung parenchymal density via ultrashort echo time MRI with comparison to CT
Journal of magnetic resonance imaging, Vol.46(4), pp.992-1000
10/2017
DOI: 10.1002/jmri.25643
PMCID: PMC6457694
PMID: 28160357
Abstract
To demonstrate that ultrashort echo time (UTE) magnetic resonance imaging (MRI) can achieve computed tomography (CT)-like quantification of lung parenchyma in free-breathing, non-sedated neonates. Because infant CTs are used sparingly, parenchymal disease evaluation via UTE MRI has potential for translational impact.
Two neonatal control cohorts without suspected pulmonary morbidities underwent either a research UTE MRI (n = 5; 1.5T) or a clinically-ordered CT (n = 9). Whole-lung means and anterior-posterior gradients of UTE-measured image intensity (arbitrary units, au, normalized to muscle) and CT-measured density (g/cm
) were compared (Mann-Whitney U-test). Separately, a diseased neonatal cohort (n = 5) with various pulmonary morbidities underwent both UTE MRI and CT. UTE intensity and CT density were compared with Spearman correlations within ∼33 anatomically matched regions of interest (ROIs) in each diseased subject, spanning low- to high-density tissues. Radiological classifications were evaluated in all ROIs, with mean UTE intensities and CT densities compared in each classification.
In control subjects, whole-lung UTE intensities (0.51 ± 0.04 au) were similar to CT densities (0.44 ± 0.09 g/cm
) (P = 0.062), as were UTE (0.021 ± 0.020 au/cm) and CT (0.034 ± 0.024 [g/cm
]/cm) anterior-posterior gradients (P = 0.351). In diseased subjects' ROIs, significant correlations were observed between UTE and CT (P ≤0.007 in each case). Relative differences between UTE and CT were small in all classifications (4-25%).
These results demonstrate a strong association between UTE image intensity and CT density, both between whole-lung tissue in control patients and regional radiological pathologies in diseased patients. This indicates the potential for UTE MRI to longitudinally evaluate neonatal pulmonary disease and to provide visualization of pathologies similar to CT, without sedation/anesthesia or ionizing radiation.
3 Technical Efficacy: Stage 2 J. Magn. Reson. Imaging 2017;46:992-1000.
Details
- Title: Subtitle
- Quantification of neonatal lung parenchymal density via ultrashort echo time MRI with comparison to CT
- Creators
- Nara S Higano - Cincinnati Children's Hospital Medical CenterRobert J Fleck - Cincinnati Children's Hospital Medical CenterDavid R Spielberg - Cincinnati Children's Hospital Medical CenterLaura L Walkup - Cincinnati Children's Hospital Medical CenterAndrew D Hahn - University of Wisconsin–MadisonRobert P Thomen - Cincinnati Children's Hospital Medical CenterStephanie L Merhar - Cincinnati Children's Hospital Medical CenterPaul S Kingma - Cincinnati Children's Hospital Medical CenterJean A Tkach - Cincinnati Children's Hospital Medical CenterSean B Fain - University of Wisconsin–MadisonJason C Woods - Cincinnati Children's Hospital Medical Center
- Resource Type
- Journal article
- Publication Details
- Journal of magnetic resonance imaging, Vol.46(4), pp.992-1000
- DOI
- 10.1002/jmri.25643
- PMID
- 28160357
- PMCID
- PMC6457694
- NLM abbreviation
- J Magn Reson Imaging
- ISSN
- 1053-1807
- eISSN
- 1522-2586
- Grant note
- T32 HL007752 / NHLBI NIH HHS P01 HL070831 / NHLBI NIH HHS T32 CA009206 / NCI NIH HHS UL1 TR001425 / NCATS NIH HHS
- Language
- English
- Date published
- 10/2017
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiology; Electrical and Computer Engineering; Health, Sport, and Human Physiology
- Record Identifier
- 9984275057902771
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