Journal article
Quantifying Nuance within Sepsis-Associated Immune Suppression toward Diagnostic Certainty
Shock (Augusta, Ga.), Vol.65(3), pp.555-559
03/2026
DOI: 10.1097/SHK.0000000000002745
PMID: 41166166
Abstract
Impact of sepsis on human T-cell function and outcome was assessed. In sepsis survivors, IFNγ-production in response to T-cell stimulation remains intact, while sepsis non-survivors display exaggerated IFNγ responses to TCR-independent stimuli.
Details
- Title: Subtitle
- Quantifying Nuance within Sepsis-Associated Immune Suppression toward Diagnostic Certainty
- Creators
- Charles C Caldwell - University of Cincinnati Medical CenterRobert Maile - Florida CollegeMonty B Mazer - Case Western Reserve UniversityPatrick W McGonagill - University of IowaChristian B Bergmann - University of Cincinnati Medical CenterRobert W Gould - University of Minnesota Medical CenterMahil Rao - University of IowaMiguel Hernández-Ríos - Florida CollegeRicardo F Ungaro - University of FloridaTyler J Loftus - Florida CollegePhilip A Efron - University of FloridaKenneth E Remy - Florida CollegeScott C Brakenridge - Harborview Medical CenterVladimir P Badovinac - University of IowaThomas S Griffith - Minneapolis VA Health Care SystemRichard S Hotchkiss - Washington University in St. LouisLyle L Moldawer - University of Florida
- Resource Type
- Journal article
- Publication Details
- Shock (Augusta, Ga.), Vol.65(3), pp.555-559
- DOI
- 10.1097/SHK.0000000000002745
- PMID
- 41166166
- NLM abbreviation
- Shock
- ISSN
- 1540-0514
- eISSN
- 1540-0514
- Publisher
- LIPPINCOTT WILLIAMS & WILKINS
- Grant note
- National Institute of General Medical Sciences: GM-132364
This work was directly supported by NIH grant R01 GM-139046-05, including a supplement (R01 GM-139046-03S1) from 2022 to 2024. Additional support was provided by NIH grants T32 GM-008721 (to P.A.E.); RM1 GM-139690 (to L.L.M. and P.A.E.); R01 GM-149657 (to T.J.L.); R35 GM-140806 (to P.A.E.); R35 GM-134880 (to V.P.B.); R35 GM-142481 (to S.C.B.); R35 GM1-140881 (to T.S.G.); R35 GM-126928 (to R.S.H.); G102983-6263608307-1 from the Department of Defense; and IK6BX006192 from the Department of Veteran Affairs (to T.S.G.). This work was also supported by National Institute of General Medical Sciences R01 GM-132364 to the Stratifying Patient Immune Endotypes in Sepsis Consortium (L.L.M. and R.M.: PD/PI). M.H.-R was supported by a T32 postdoctoral training grant in shock, trauma, and sepsis, awarded by the National Institute of General Medical Sciences (to P.A.E. T32 GM-008721).
- Language
- English
- Electronic publication date
- 10/21/2025
- Date published
- 03/2026
- Academic Unit
- Critical Care; Stead Family Department of Pediatrics; Pathology; Surgery
- Record Identifier
- 9985022567902771
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